Results 41 to 50 of about 7,522 (226)
Magnesium ions mediate ligand binding and conformational transition of the SAM/SAH riboswitch
Communications Biology, 2023 The SAM/SAH riboswitch binds S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) with similar affinities. Mg2+ is generally known to stabilize RNA structures by neutralizing phosphates, but how it contributes to ligand binding and conformational ...
Guodong Hu, Huan-Xiang Zhou
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Microbiology Spectrum, 2022 The trace metal manganese in excess affects iron-sulfur cluster and heme-protein biogenesis, eliciting cellular toxicity. The manganese efflux protein MntP is crucial to evading manganese toxicity in bacteria.
Arunima Kalita +4 more
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Classification of Riboswitch Families Using Block Location-Based Feature Extraction (BLBFE) Method [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Riboswitches are special non-coding sequences usually located in mRNAs’ un-translated regions and regulate gene expression and consequently cellular function. Furthermore, their interaction with antibiotics has been recently implicated.
Faegheh Golabi +4 more
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Riboswitch diversity and distribution [PDF]
RNA, 2017 Riboswitches are commonly used by bacteria to detect a variety of metabolites and ions to regulate gene expression. To date, nearly 40 different classes of riboswitches have been discovered, experimentally validated, and modeled at atomic resolution in complex with their cognate ligands.
Phillip J. McCown +4 more
openaire +2 more sources
RATEX: A Scalable RNA‐Based Platform for Logical and Multi‐Layered Cellular Programming
Angewandte Chemie, EarlyView.RATEX integrated ribosome‐mediated transcription control with synthetic RNA regulators, enabling simultaneous processing of RNA, metabolite, and small‐molecule inputs through complex logic operations within a single transcript. The platform achieves up to 1,492‐fold gene regulation, multi‐input hybrid logic gates, RNA‐programmed signaling cascades, and
Hyunseop Goh +3 more
wiley +2 more sources
BMC Research Notes, 2018 Objective The purpose of this project was to use an in vivo method to discover riboswitches that are activated by new ligands. We employed phage-assisted continuous evolution (PACE) to evolve new riboswitches in vivo.
Zachary M. Shaver +30 more
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Purine sensing by riboswitches [PDF]
Biology of the Cell, 2008 Structured mRNA elements called riboswitches control gene expression by binding to small metabolites. Over a dozen riboswitch classes have been characterized that target a broad range of molecules and vary widely in size and secondary structure. Four of the known riboswitch classes recognize purines or modified purines.
Jane N, Kim, Ronald R, Breaker
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Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms. [PDF]
PLoS Genetics, 2011 Many bacterial mRNAs are regulated at the transcriptional or translational level by ligand-binding elements called riboswitches. Although they both bind adenine, the adenine riboswitches of Bacillus subtilis and Vibrio vulnificus differ by controlling ...
Jean-François Lemay +7 more
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Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo +3 more
wiley +2 more sources
A novel riboswitch classification based on imbalanced sequences achieved by machine learning.
PLoS Computational Biology, 2020 Riboswitch, a part of regulatory mRNA (50-250nt in length), has two main classes: aptamer and expression platform. One of the main challenges raised during the classification of riboswitch is imbalanced data.
Solomon Shiferaw Beyene +3 more
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