Results 61 to 70 of about 7,522 (226)
Cell Reports, 2023 Summary: Natural polyamines such as spermidine and spermine cations have characteristics that make them highly likely to be sensed by riboswitches, such as their general affinity to polyanionic RNA and their broad contributions to cell physiology ...
Hubert Salvail +3 more
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Riboswitches in unexpected places—A synthetic riboswitch in a protein coding region [PDF]
RNA, 2008 In natural and engineered systems, cis-RNA regulatory elements such as riboswitches are typically found within untranslated regions rather than within the protein coding sequences of genes. However, RNA sequences with important regulatory roles can exist within translated regions.
Shana, Topp, Justin P, Gallivan
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Molecular Microbiology, EarlyView.Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan +2 more
wiley +1 more source
Riboswitches: Fold and Function
Chemistry & Biology, 2006 Riboswitches in the 5'-untranslated regions of mRNAs cotranscriptionally couple ligand binding and gene regulation. In this issue of Chemistry & Biology, Lemay et al. describe folding of a key tertiary interaction in the adenine riboswitch and its mechanistic consequences.
Gilbert, Sunny D., Batey, Robert T.
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Singlet glycine riboswitches bind ligand as well as tandem riboswitches [PDF]
RNA, 2016 The glycine riboswitch often occurs in a tandem architecture, with two ligand-binding domains (aptamers) followed by a single expression platform. Based on previous observations, we hypothesized that “singlet” versions of the glycine riboswitch, which contain only one aptamer domain, are able to bind glycine if appropriate structural contacts are ...
Ruff, Karen M. +4 more
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Dynamic energy landscapes of riboswitches help interpret conformational rearrangements and function. [PDF]
PLoS Computational Biology, 2012 Riboswitches are RNAs that modulate gene expression by ligand-induced conformational changes. However, the way in which sequence dictates alternative folding pathways of gene regulation remains unclear.
Giulio Quarta, Ken Sin, Tamar Schlick
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Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling
Angewandte Chemie International Edition, Volume 65, Issue 23, 1 June 2026.Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl +1 more
wiley +1 more source
Riboswitches as hormone receptors: hypothetical cytokinin-binding riboswitches in Arabidopsis thaliana [PDF]
Biology Direct, 2010 Riboswitches are mRNA elements that change conformation when bound to small molecules. They are known to be key regulators of biosynthetic pathways in both prokaryotes and eukaryotes.The hypothesis presented here is that riboswitches function as receptors in hormone perception.
Downes Brian, Grojean Jeremy
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Virulence, 2020 The proliferation of antibiotic resistance has its origins in horizontal gene transfer. The class 1 integrons mediate gene transfer by assimilating antibiotic-resistance genes through site-specific recombination.
Jun Zhang +8 more
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RNA folding kinetics control riboswitch sensitivity in vivo
Nature CommunicationsRiboswitches are ligand-responsive gene-regulatory RNA elements that perform key roles in maintaining cellular homeostasis. Understanding how riboswitch sensitivity to ligand (EC50) is controlled is critical to explain how highly conserved aptamer ...
David Z. Bushhouse +2 more
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