Results 61 to 70 of about 7,960 (219)
, 2010 A metabolite-sensing riboswitch regulates the splicing of a “selfish” group I self-splicing ribozyme.
Guy Riddihough
core +1 more source
Model of glycine riboswitch evolution. [PDF]
, 2019 Model proposed for the evolution and divergence of the glycine riboswitch. In this model a progenitor tandem riboswitch conserves one of the tandem aptamers based on the genomic context of the riboswitch, while the other slowly degrades down to the ...
Nikhil Ram-Mohan (6054242) +2 more
core +1 more source
Riboswitches: Structures and Mechanisms [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 A critical feature of the hypothesized RNA world would have been the ability to control chemical processes in response to environmental cues. Riboswitches present themselves as viable candidates for a sophisticated mechanism of regulatory control in RNA-based life.
Andrew D, Garst +2 more
openaire +2 more sources
Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation. [PDF]
, 2017 International audienceOn the basis of nascent transcript sequencing, it has been postulated but never demonstrated that transcriptional pausing at translation start sites is important for gene regulation.
Dubé, Audrey +9 more
core +1 more source
Incoherent dual regulation by a SAM-II riboswitch controlling translation at a distance
RNA Biology, 2022 In Sinorhizobium meliloti, the methionine biosynthesis genes metA and metZ are preceded by S-adenosyl-L-methionine (SAM) riboswitches of the SAM-II class. Upon SAM binding, structural changes in the metZ riboswitch were predicted to cause transcriptional
Robina Scheuer +5 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo +3 more
wiley +2 more sources
Bifidobacterium bifidum SAM-VI Riboswitch Conformation Change Requires Peripheral Helix Formation
BiomoleculesThe Bifidobacterium bifidum SAM-VI riboswitch undergoes dynamic conformational changes that modulate downstream gene expression. Traditional structural methods such as crystallography capture the bound conformation at high resolution, and additional ...
Wenwen Xiao +4 more
doaj +1 more source
Conformational dynamics of the tetracycline-binding aptamer [PDF]
, 2011 The conformational dynamics induced by ligand binding to the tetracycline-binding aptamer is monitored via stopped-flow fluorescence spectroscopy and time-correlated single photon counting experiments.
Weigand, Julia E. +10 more
core +1 more source
An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system
Scientific Reports, 2017 Riboswitches are bacterial RNA elements that regulate gene expression in response to metabolite or ion abundance and are considered as potential drug targets. In recent years a number of methods to find non-natural riboswitch ligands have been described.
Marion Kirchner +3 more
doaj +1 more source
Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation
Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova +2 more
wiley +2 more sources