Results 51 to 60 of about 7,960 (219)
Purine sensing by riboswitches [PDF]
Biology of the Cell, 2008 Structured mRNA elements called riboswitches control gene expression by binding to small metabolites. Over a dozen riboswitch classes have been characterized that target a broad range of molecules and vary widely in size and secondary structure. Four of the known riboswitch classes recognize purines or modified purines.
Jane N, Kim, Ronald R, Breaker
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Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast [PDF]
, 2007 Splicing of pre-mRNA is a critical step in mRNA maturation and disturbances cause several genetic disorders. We apply the synthetic tetracycline (tc)-binding riboswitch to establish a gene expression system for conditional tc-dependent control of pre ...
Weigand, Julia E. +3 more
core +1 more source
Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms. [PDF]
PLoS Genetics, 2011 Many bacterial mRNAs are regulated at the transcriptional or translational level by ligand-binding elements called riboswitches. Although they both bind adenine, the adenine riboswitches of Bacillus subtilis and Vibrio vulnificus differ by controlling ...
Jean-François Lemay +7 more
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Thermodynamic characterization of an engineered tetracycline-binding riboswitch [PDF]
, 2006 Riboswitches reflect a novel concept in gene regulation that is particularly suited for technological adaptation. Therefore, we characterized thermodynamically the ligand binding properties of a synthetic, tetracycline (tc)-binding RNA aptamer, which ...
Weigand, Julia E. +8 more
core +1 more source
Structure of a rare non-standard sequence k-turn bound by L7Ae protein [PDF]
, 2014 Kt-23 from Thelohania solenopsae is a rare RNA kink turn (k-turn) where an adenine replaces the normal guanine at the 2n position. L7Ae is a member of a strongly conserved family of proteins that bind a range of k-turn structures in the ribosome, box C/D
Huang, Lin, Lilley, David M J; id_orcid
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A critical base pair in k-turns that confers folding characteristics and correlates with biological function [PDF]
, 2014 Kink turns (k-turns) are widespread elements in RNA that mediate tertiary contacts by kinking the helical axis. We have found that the ability of k-turns to undergo ion-induced folding is conferred by a single base pair that follows the conserved A·G ...
Lilley, David M. J.; id_orcid +2 more
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, 2018 Within the life sciences switching mechanisms are pervasive at all levels, from molecules to cells and tissues. Their operation can be a key determinant of health or disease.
Spurgeon, Sarah +7 more
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Affinity-Based Profiling of the Flavin Mononucleotide Riboswitch [PDF]
, 2022 [Image: see text] Riboswitches are structural RNA elements that control gene expression. These naturally occurring RNA sensors are of continued interest as antibiotic targets, molecular sensors, and functional elements of synthetic circuits.
Crielaard, Stefan +9 more
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A novel riboswitch classification based on imbalanced sequences achieved by machine learning.
PLoS Computational Biology, 2020 Riboswitch, a part of regulatory mRNA (50-250nt in length), has two main classes: aptamer and expression platform. One of the main challenges raised during the classification of riboswitch is imbalanced data.
Solomon Shiferaw Beyene +3 more
doaj +1 more source
RSC Chemical Biology, 2021 Synthetic riboswitches can be used as chemical gene switches in cell-free protein synthesis systems. We provide a current perspective on the state of cell-free riboswitch technologies and their future directions.
Takeshi Tabuchi, Yohei Yokobayashi
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