Results 31 to 40 of about 7,522 (226)
Frontiers in Molecular Biosciences, 2022 Riboswitch RNAs regulate gene expression by conformational changes induced by environmental conditions and specific ligand binding. The guanidine-II riboswitch is proposed to bind the small molecule guanidinium and to subsequently form a kissing loop ...
Christin Fuks +4 more
doaj +1 more source
Cell, 2006 Riboswitches are common cis-acting regulatory elements in bacteria. They are made of nascent RNA that changes its conformation in response to direct binding of cognate metabolites. The publication of five high-resolution crystal structures provides a comprehensive view of how riboswitches sense their ligands and points to new challenges in this ...
openaire +2 more sources
A riboswitch-based inducible gene expression system for mycobacteria. [PDF]
PLoS ONE, 2012 Research on the human pathogen Mycobacterium tuberculosis (Mtb) would benefit from novel tools for regulated gene expression. Here we describe the characterization and application of a synthetic riboswitch-based system, which comprises a mycobacterial ...
Jessica C Seeliger +5 more
doaj +1 more source
A transient conformation facilitates ligand binding to the adenine riboswitch
iScience, 2021 Summary: RNAs adopt various conformations to perform different functions in cells. Incapable of acquiring intermediates, the key initiations of ligand recognition in the adenine riboswitch have not been characterized.
Lin Wu, Dian Chen, Jienyu Ding, Yu Liu
doaj +1 more source
PLoS ONE, 2020 Riboswitches, generally located in the 5'-leader of bacterial mRNAs, direct expression via a small molecule-dependent structural switch that informs the transcriptional or translational machinery.
Lea K Drogalis, Robert T Batey
doaj +1 more source
Translational gene expression control in Chlamydia trachomatis.
PLoS ONE, 2022 The human pathogen Chlamydia trachomatis proceeds through a multi phenotypic developmental cycle with each cell form specialized for different roles in pathogenesis.
Nicole A Grieshaber +5 more
doaj +1 more source
Mix-and-Match Riboswitches [PDF]
ACS Chemical Biology, 2006 Riboswitches are noncoding RNA elements found in the 5'-untranslated region of messenger RNA (mRNA) that mediate gene expression in a cis fashion in the absence of protein. This common regulatory strategy in bacteria is achieved through the interplay of two distinct domains: an aptamer domain responsible for sensing intracellular concentrations of a ...
Colby D, Stoddard, Robert T, Batey
openaire +2 more sources
Architectures and complex functions of tandem riboswitches
RNA Biology, 2022 Riboswitch architectures that involve the binding of a single ligand to a single RNA aptamer domain result in ordinary dose-response curves that require approximately a 100-fold change in ligand concentration to cover nearly the full dynamic range for ...
Madeline E. Sherlock +14 more
doaj +1 more source
iScience, 2023 Summary: Metabolic homeostasis is regulated by enzyme activities, but the importance of regulating their corresponding coenzyme levels is unexplored. The organic coenzyme thiamine diphosphate (TDP) is suggested to be supplied as needed and controlled by ...
Zeenat Noordally +6 more
doaj +1 more source
The intricate world of riboswitches [PDF]
Current Opinion in Microbiology, 2007 Riboswitches are segments of the 5'-untranslated region of certain bacterial mRNAs that upon recognition of specific ligands modify the expression of a protein(s) encoded in the message. These proteins are responsible for the biosynthesis or transport of ligands, which are typically organic molecules but could also be metal ions.
Rebecca L, Coppins +2 more
openaire +2 more sources