Results 11 to 20 of about 7,522 (226)

Potential effects of metal ion induced two-state allostery on the regulatory mechanism of add adenine riboswitch [PDF]

Communications Biology, 2022
Molecular dynamic simulations are employed to assess the influence of metal ions on riboswitch structure and dynamics, suggesting a conformational control of riboswitch aptamers by metal ions before ligand binding.
Lei Bao, Wen-Bin Kang, Yi Xiao
doaj   +2 more sources

In Vivo Behavior of the Tandem Glycine Riboswitch in Bacillus subtilis [PDF]

mBio, 2017
In many bacterial species, the glycine riboswitch is composed of two homologous ligand-binding domains (aptamers) that each bind glycine and act together to regulate the expression of glycine metabolic and transport genes.
Arianne M. Babina, Nicholas E. Lea, Michelle M. Meyer   +2 more
doaj   +2 more sources

Structural Basis for Molecular Discrimination by a 3′,3′-cGAMP Sensing Riboswitch [PDF]

Cell Reports, 2015
Cyclic dinucleotides are second messengers that target the adaptor STING and stimulate the innate immune response in mammals. Besides protein receptors, there are bacterial riboswitches that selectively recognize cyclic dinucleotides.
Aiming Ren, Xin C. Wang, Colleen A. Kellenberger, Kanagalaghatta R. Rajashankar, Roger A. Jones, Ming C. Hammond, Dinshaw J. Patel   +6 more
doaj   +2 more sources

Cyclic Amide-Linked Oxazolidinone Triazoles as Inhibitors of the T-Box Riboswitch [PDF]

Molecules
Antimicrobial resistance remains a critical global health challenge, and was intensified by the COVID-19 pandemic. To address this growing threat, novel antibacterial agents targeting unconventional mechanisms are urgently needed.
Eric Parsons, Ali H. Aldhumani, Emily A. Fairchild, Oluwaseun B. Adegbite, Jessica M. Roberts, Jennifer V. Hines, Stephen C. Bergmeier   +6 more
doaj   +2 more sources

Riboswitch-controlled lipid conversion enables functional membrane asymmetry in artificial cells [PDF]

Communications Biology
Dynamic regulation of lipid membrane composition is fundamental to living cells; however, synthetic analogs capable of such regulation remain scarce. Here, we present an artificial cell platform in which riboswitch-mediated expression of phospholipase D (
Koki Kamiya, Sumin Lee, Kotaro Baba
doaj   +2 more sources

Designing molecular RNA switches with Restricted Boltzmann machines [PDF]

Nature Communications
Riboswitches are structured allosteric RNA molecules that change conformation upon metabolite binding, triggering a regulatory response. Here we focus on the de novo design of riboswitch-like aptamers, the core part of the riboswitch undergoing ...
Jorge Fernandez-de-Cossio-Diaz, Pierre Hardouin, Francois-Xavier Lyonnet du Moutier, Andrea Di Gioacchino, Bertrand Marchand, Yann Ponty, Bruno Sargueil, Rémi Monasson, Simona Cocco   +8 more
doaj   +2 more sources

Polycationic Peptides That Bind T-Box Riboswitch Antiterminator RNA and Inhibit Riboswitch Function. [PDF]

Chem Biol Drug Des
Polycationic decapeptides inhibit T‐box riboswitch tRNA‐induced transcription readthrough. ABSTRACT Resistance to antibiotic treatments continues to be a significant health challenge and necessitates investigating novel antibacterial targets including noncoding regulatory RNA.
Fairchild E, Herath D, Lux S, Harvey SR, Amesaki D, McCartney D, Richter M, Hoffmann R, Hines JV.   +8 more
europepmc   +2 more sources

Riboswitches

Current Biology, 2023
Riboswitches are structured noncoding RNA domains that are typically found embedded in messenger RNAs, where they sense specific target molecules or elemental ions and regulate gene expression. These RNAs thus serve as genetic switches that can activate or repress gene expression in response to changing levels of their target ligand. To many observers,
Salvail, Hubert, Breaker, Ronald R.
openaire   +2 more sources

Mutations of N1 Riboswitch Affect its Dynamics and Recognition by Neomycin Through Conformational Selection

Frontiers in Molecular Biosciences, 2021
Short, structured fragments of non-coding mRNA may act as molecular switches upon binding specific ligands, regulating the translation of proteins encoded downstream this mRNA sequence.
Piotr Chyży, Piotr Chyży, Marta Kulik, Marta Kulik, Suyong Re, Suyong Re, Yuji Sugita, Yuji Sugita, Yuji Sugita, Joanna Trylska   +9 more
doaj   +1 more source

Critical Role of Mg²⁺ Ions in RNA Folding Transitions: Anchoring the A-Minor Twist in the SAM-II Riboswitch [PDF]

J Phys Chem B
Rafael Giordano Viegas, Anushree Sinha, Avijit Mainan, Karissa Y. Sanbonmatsu, José N. Onuchic, Susmita Roy, Vitor B. P. Leite   +6 more
openalex   +2 more sources