Results 291 to 300 of about 133,980 (384)

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

Thermally Activated and Nonactivated Excited State Decay of [Cr(dgpy)₂]³. [PDF]

Inorg Chem
Sittel S, Naumann R, Förster C, Huber ME, Meyer J, Heinze K.   +5 more
europepmc   +1 more source

Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis. [PDF]

Nat Commun
Jiang W, Zhou M, Chen K, Xiao X, Shi J, Zhang H, Xie J, Chen S, Chen M, Cong Z, Liu L, Wu Y, Liu R.   +12 more
europepmc   +1 more source

Automated Solid Phase Synthesis of Stapled Oligopeptides as Covalent PAD4 Inhibitors

Peptide Science, Volume 118, Issue 1, January 2026.
ABSTRACT We demonstrate our results with the synthesis of inhibitors of Protein Arginine Deaminase 4 (PAD4), a key regulator of neutrophil elastase extracellular traps (NETs), as potential therapeutics for chronic obstructive pulmonary disease (COPD). Furthermore, we report an automated method for solid phase synthesis of macrocyclic stapled peptides ...
Antoine Magniez, Frank Jansen, Ranganath Gopalakrishnan, Lena von Sydow, Karin Kaspersson, Tommy Thorsell, Antonios Nikitidis, Leonardo De Maria, Wu Su, Sunay V. Chankeshwara, Pavol Zlatoidský   +10 more
wiley   +1 more source

Variation in phylogenetic tendencies of contiguous riboswitches. [PDF]

Microb Genom
Morales N, Merino E.
europepmc   +1 more source

Guanidine functionalized porous SiO₂ as heterogeneous catalysts for microwave depolymerization of PET and PLA

Éadaoin Casey, Rachel Breen, Gerard Pareras, Albert Rimola, Justin D. Holmes, Gillian Collins   +5 more
openalex   +2 more sources

Paving the Way Toward New Push‐Pull Superbases in the Gas Phase by an Effective DFT Approach: The Case of a New Structurally Complex Molecule, 5‐Aminopyrrole‐2‐Amidine

Journal of Physical Organic Chemistry, Volume 39, Issue 1, January 2026.
DFT calculations, carried out in the gas phase for all possible tautomers of 5‐aminopyrrole‐2‐amidine (APA), permit the estimation of their relative stabilities and allow the selection of energetically favored forms. All tautomers are push‐pull imino N‐bases that exhibit calculated basicities in the higher range of the current gas‐phase basicity scale.
Ewa Daniela Raczyńska, Jean‐Francois Gal, Pierre‐Charles Maria   +2 more
wiley   +1 more source

A Dive Into Forty Years of Research on Organic Superbases: From Design to Applications. [PDF]

J Comput Chem
Lo R, Ganguly B.
europepmc   +1 more source

A Standard Operating Procedure for Protein Extraction From Abdominal Aortic Aneurysm Tissue: Enhancing Proteomics Applications

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Purpose The identification of putative biomarkers for AAA can be achieved through shotgun proteomics. However, tissue heterogeneity hampers its reproducible homogenization and protein extraction. Thus, we aimed to optimize a protocol to maximize protein yield and develop an SOP to foster reproducibility and accelerate translation of proteomics
Telmo Baltazar, Fábio Trindade, Rita Nogueira‐Ferreira, Rui Vitorino, Rita Ferreira, Pedro Domingues, Adelino Leite‐Moreira, Marina Dias‐Neto, VASCUL‐AID Consortium, Kak Khee Yeung, Vincent Jongkind, Lotte Rijken, Sabrina Zwetsloot, Venkat Ayyalasomayajula, Stefan Smorenburg, Jelmer Wolterink, Henk Marquering, Ivana Išgum, Corrette Ploem, Fabio Catarinella, Regent Lee, Katarzyna D Bera, Juliette Raffort, Fabien Lareyre, Catelijne Muller, Igor Koncar, Ivan Tomic, David Matejevic, Maja Živković, Tamara Djuric, Aleksandra Stankovic, Maarit Venermo, Riikka Tulamo, Mirjami Laivuori, Christian‐Alexander Behrendt, Noeska Smit, Marlies Schijven, Bert‐Jan van den Born, Ronak Delewi   +38 more
wiley   +1 more source

Structure-Based Discovery of Potent and Selective Small-Molecule α5β1 Integrin Inhibitors for Asthma Therapy. [PDF]

ACS Omega
Beresis R, Sundaram A, Jo H, Adler M, Wang Z, McIntosh J, Yeon SK, Huang Q, Ngo G, Sheppard D, DeGrado WF.   +10 more
europepmc   +1 more source