Results 301 to 310 of about 133,980 (384)

Hydrogen‐deuterium exchange reveals catalytically linked protein flexibility in myoglobin‐mediated intramolecular C(sp3)‐H activation

Protein Science, Volume 35, Issue 1, January 2026.
Abstract A comprehensive understanding of the biophysical parameters that dictate high catalytic efficiency in enzymes is essential for advancing both fundamental enzymology and its applications. Experimental evidence suggests that protein dynamics play a pivotal role in transiently shaping active site configurations, facilitating the efficient ...
Hanzi Gao, Edgar Africano Camargo, Jude N. Ubi, Xiuyuan Duan, Xiaolin Tian, Haiteng Deng, Guojun Zheng, Shuaihua Gao   +7 more
wiley   +1 more source

A General Synthesis Approach to Double-Guanidinium Stapled Peptides and Foldamers. [PDF]

Chemistry
Neuville M, Bornez MM, Bourgeais M, Samueli H, Mauran L, Goudreau SR, Khatib AM, Guichard G, Pasco M.   +8 more
europepmc   +1 more source

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Human RNA capping is critical for mRNA splicing, protection of RNA from 5′ exonucleases in the cytoplasm, and targeting to the ribosome. Human RNMT, CMTR1, and CMTR2 are RNA methyltransferases involved in the RNA capping process. They play a significant role in the proliferation and differentiation of embryonic stem cells and have been ...
Fatemeh Taherian, Mark F. Mabanglo, Taraneh Hajian, Sarah Tucker, Emilija Kalinic, Sumera Perveen, Ahmed Aman, Masoud Vedadi   +7 more
wiley   +1 more source

Silver-Conjugated-Polyarginine Anchored Cotton Fabrics Exhibit Durable and Efficient Antimicrobial Properties. [PDF]

ACS Omega
Zhen J, Sun A, Yang L, Wang R, Liu M, Liu Y, Zhang W.   +6 more
europepmc   +1 more source

Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri‐Implant Lesions

Journal of Clinical Periodontology, Volume 53, Issue 1, Page 137-151, January 2026.
ABSTRACT Aim To analyse gene expression profiles in human tissue samples obtained from dental implant sites with or without peri‐implantitis. Materials and Methods Soft‐tissue biopsy samples obtained from patients presenting with implants with severe peri‐implantitis and adjacent reference implants with no signs of peri‐implantitis were analysed by ...
C. Dionigi, A. C. Ericson, A. Shikhan, L. Larsson, T. Berglundh   +4 more
wiley   +1 more source

Electrochemical Conversion of Low-Concentration CO₂ Promoted by a Guanidine Polymer. [PDF]

JACS Au
Pan YZ, Lin XC, Liang Y, Xia Q, Cui FH, Tang HT, Pan YM.   +6 more
europepmc   +1 more source

Undermining the cry for help: the phytopathogenic fungus Verticillium dahliae secretes an antimicrobial effector protein to undermine host recruitment of antagonistic Pseudomonas bacteria

New Phytologist, Volume 249, Issue 1, Page 406-417, January 2026.
Summary During pathogen attack, plants recruit beneficial microbes in a ‘cry for help’ to mitigate disease development. Simultaneously, pathogens secrete effectors to promote host colonisation through various mechanisms, including targeted host microbiota manipulation.
Anton Kraege, Wilko Punt, Andrea Doddi, Jinyi Zhu, Natalie Schmitz, Nick C. Snelders, Bart P. H. J. Thomma   +6 more
wiley   +1 more source

Opioid Affinity of Diazacyclic Peptidomimetic Compounds Derived from Reduced Polyamides. [PDF]

Int J Mol Sci
Chaudhari P, Bunnell A, Yegambaram M, Dooley C, Nefzi A.   +4 more
europepmc   +1 more source

Development of Norrin-Based Protein Therapeutic for Activation of Norrin-Wnt Signaling in Human Retinal Endothelial Cells. [PDF]

Int J Mol Sci
Mitton KP, Dailey WA, Krikor SQ, Drenser KA.   +3 more
europepmc   +1 more source