Results 71 to 80 of about 2,442 (194)

Effects of guanidinoacetic acid supplementation on growth performance, hypothalamus-pituitary-adrenal axis, and immunity of broilers challenged with chronic heat stress

Poultry Science, 2023
: Heat stress can cause systemic immune dysregulation and threaten the health of broilers. Guanidinoacetic acid (GAA) has been shown to be effective against heat stress, but whether it is beneficial for immunity is unclear.Therefore, the effects of ...
Xin Li, Jiawei Bian, Tong Xing, Liang Zhao, Jiaolong Li, Lin Zhang, Feng Gao   +6 more
doaj   +1 more source

Guanidinoacetic acid supplementation on growth performance and molecular mechanisms of lean mass gain in nursery pigs [PDF]

Ciência Rural, 2020
: The objective with the present study was to evaluate the effect of guanidinoacetic acid (GAA) on the growth performance of nursery piglets as well as a possible molecular mechanism of action on lean mass gain. Seventy-two pigs, weaned at 21 d, weighing
Graziela Alves da Cunha Valini, Marcio de Souza Duarte, Gustavo de Amorim Rodrigues, Renata Veroneze, Alysson Saraiva, Gary Hausman, Gabriel Cipriano Rocha   +6 more
doaj   +1 more source

Dietary supplementation of guanidinoacetic acid for sows and their progenies: performance, blood parameters and economic viability at nursery phase [PDF]

, 2019
The aim of this study was to evaluate the effects of guanidinoacetic acid supplementation for sows and their litter on performance, blood parameters and economic viability of piglets at nursery phase.
Ana Cláudia Nascimento Campos, Bruno Alexander Nunes Silva, Ingrid Barbosa de Mendonça, Josiane Carla Panisson, Marcel Manente Boiago, Mayara Alves da Silva Perrut de Mello, Pedro Henrique Watanabe, Tiago Silva Andrade   +7 more
core   +1 more source

Effects of feeding guanidinoacetic acid on oxidative status and creatine metabolism in broilers subjected to chronic cyclic heat stress in the finisher phase

Poultry Science, 2023
: Dietary guanidinoacetic acid (GAA) has been shown to affect creatine (Cr) metabolic pathways resulting in increased cellular Cr and hitherto broiler performances. Yet, the impact of dietary GAA on improving markers of oxidative status remains equivocal.
M. Majdeddin, U. Braun, A. Lemme, A. Golian, H. Kermanshahi, S. De Smet, J. Michiels   +6 more
doaj   +1 more source

Metabolomics and Lipidomics Signatures of Insulin Resistance and Abdominal Fat Depots in People Living with Obesity

, 2022
The liver, skeletal muscle, and adipose tissue are major insulin target tissues and key players in glucose homeostasis. We and others have described diverse insulin resistance (IR) phenotypes in people at risk of developing type 2 diabetes.
Batarseh, A, Chen, DL, Coster, ACF , Greenfield, JR , Koay, YC, Milner, B, O’Sullivan, JF, Samocha-Bonet, D   +7 more
core   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: a review. [PDF]

, 2008
Creatine deficiency syndromes, either due to AGAT, GAMT or SLC6A8 deficiencies, lead to a complete absence, or a very strong decrease, of creatine within the brain, as measured by magnetic resonance spectroscopy.
Braissant, O., Henry, H.
core   +1 more source

Dynamic electro‐clinical features in Guanidinoacetate N‐methyltransferase deficiency: A familial case series

Epilepsia Open, Volume 10, Issue 4, Page 1244-1252, August 2025.
Abstract Guanidinoacetate N‐methyltransferase deficiency is an inborn error of creatine metabolism, responsible for the absent conversion of guanidinoacetic acid into creatine, resulting in cerebral creatine deficit. It could present a variety of symptoms such as neurodevelopmental delay, epilepsy, movement disorder (ataxia, dystonia, and chorea), and ...
Mariapaola Schifino, Emanuele Bartolini, Stefano Pagano, Camilla Meossi, Rosa Pasquariello, Roberta Battini   +5 more
wiley   +1 more source

Dietary guanidinoacetic acid increases the longissimus dorsi muscle depth of finishing pigs without requiring a higher standardised ileal digestible methionine + cysteine concentration

Italian Journal of Animal Science, 2022
The objective of this study was to evaluate the interaction of guanidinoacetic acid (GAA) with standardised ileal digestible methionine + cysteine (SID Met + Cys) levels in finishing pig diets on the performance, carcase characteristics, pork quality ...
Natália Yoko Sitanaka, Alice Eiko Murakami, Lucas Antônio Costa Esteves, Paula Carina de Oliveira, Eliane Gasparino, Angélica de Souza Khatlab, Paulo Cesar Pozza   +6 more
doaj   +1 more source

Long‐Term Efficacy and Tolerability of Pegzilarginase in Arginase 1 Deficiency: Results of Two International Multicentre Open‐Label Extension Studies

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Arginase 1 deficiency (ARG1‐D) is an autosomal recessive urea cycle disorder characterised by chronic hyperargininaemia, progressive spasticity, loss of mobility, and cognitive dysfunction. Standard of care (SOC), based on dietary protein restriction, rarely prevents progression.
Markey McNutt, Frank Rutsch, Rossana Sanchez Russo, Serena Gasperini, Spyros Batzios, Elisa Leão Teles, Anaïs Brassier, Jaya Ganesh, Andreas Schulze, Gregory M. Enns, Mattias Rudebeck   +10 more
wiley   +1 more source