Results 141 to 150 of about 316,659 (284)

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Guanine quadruplex structures localize to heterochromatin [PDF]

, 2017
Roland F. Hoffmann, Yuri M. Moshkin, Stijn Mouton, Nicola A. Grzeschik, Ruby D. Kalicharan, Jeroen Kuipers, Anouk H. G. Wolters, Kazuki Nishida, А. В. Ромащенко, Jan Postberg, Hans J. Lipps, Eugène Berezikov, Ody C.M. Sibon, Ben N. G. Giepmans, Peter M. Lansdorp   +14 more
openalex   +1 more source

Hedamycin intercalates the DNA helix and, through carbohydrate-mediated recognition in the minor groove, directs N7-alkylation of guanine in the major groove in a sequence-specific manner

, 1995
Mark R. Hansen, Sang Won Yun, Laurence H. Hurley   +2 more
openalex   +1 more source

bis -Molybdopterin Guanine Dinucleotide Is Required for Persistence of Mycobacterium tuberculosis in Guinea Pigs [PDF]

, 2014
Monique J. Williams, Crystal A. Shanley, Andrew Zilavy, Blas Peixoto, Claudia Manca, Gilla Kaplan, Ian M. Orme, Valerie Mizrahi, Bavesh D Kana   +8 more
openalex   +1 more source

B cells and systemic sclerosis interstitial lung disease

Arthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman, Voon Ong, Christopher Denton   +2 more
wiley   +1 more source

Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, EarlyView.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Guanine crystal formation by the unicellular organism Phacotus lenticularis is part of a cellular stress response.

PLoS ONE
Organic crystals, and in particular guanine crystals, are widely used by multicellular organisms for manipulating light and producing structural colors.
Noy Shaked, Andrea Sorrentino, Neta Varsano, Sefi Addadi, Ziv Porat, Iddo Pinkas, Steve Weiner, Lia Addadi   +7 more
doaj   +1 more source

Discriminatory Residues in Ras and Rap for Guanine Nucleotide Exchange Factor Recognition

, 1999
N van den Berghe, Robbert H. Cool, Alfred Wittinghofer   +2 more
openalex   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Substrate inhibition in a human variant of hypoxanthine-guanine phosphoribosyltransferase.

, 1984
Lafras M. Steyn, Eric H. Harley
openalex   +1 more source