Results 161 to 170 of about 158,534 (314)

Peptide‐based covalent inhibitors of protein–protein interactions

Journal of Peptide Science, Volume 29, Issue 1, January 2023., 2023
Peptide interaction motifs derived from a protein–protein interaction interface can serve as starting points for the development of inhibitors. However, for certain proteins when applying competitive inhibitors, peptide‐based ligands with an irreversible binding mode may be more active. This review summarizes examples of covalent inhibitors that employ
Felix M. Paulussen, Tom N. Grossmann
wiley   +1 more source

GUANINE AS A COENZYME IN ENZYMATIC TRANSPHOSPHORYLATION

, 1945
Sidney P. Colowick, Winston H. Price
openalex   +1 more source

Inhibition by adenine of Staphylococcus aureus growth in a nutrient medium free from guanine, guanosine, or hypoxanthine [PDF]

, 1966
J. de Repentigny, S Grimard, Patricia Turgeon, S Sonea   +3 more
openalex   +1 more source

Light‐responsive mononucleotide coacervates

Chemistry – A European Journal, Accepted Article.
Liquid‐liquid phase separation (LLPS) is central to the formation of biomolecular condensates in modern cells and is also explored as a mechanism for assembling protocells. Phase‐separated droplets provide dynamic micro‐environments that concentrate reactants, enhance reactions, and allow molecular exchange, essential for both cellular regulation and ...
Edison Rafael Jimenez Granda, Hedi Karoui, Xavier Brilland, Jean-Christophe Baret, Nicolas Martin   +4 more
wiley   +1 more source

A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension

Cytoskeleton, EarlyView.
Abstract Tissue tension encompasses the mechanical forces exerted on solid tissues within animal bodies, originating from various sources such as cellular contractility, interactions with neighboring cells and the extracellular matrix. Emerging evidence indicates that an imbalance in such forces can influence structural organization, homeostasis, and ...
Wan J. Gan, Rabina Giri, Jakob Begun, Helen E. Abud, Edna C. Hardeman, Peter W. Gunning, Alpha S. Yap, Ivar Noordstra   +7 more
wiley   +1 more source

LES CONSTITUANTS MINEURS DES ACIDES RIBONUCLÉIQUES SOLUBLES. I. — DOSAGE DES DÉRIVÉS MÉTHYLÉS DE LA GUANINE [PDF]

, 1966
Guy Pétrissant, P. Gaye
openalex   +1 more source

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

Thermodynamic Insights on the Structure‐Property Relationships in Substituted Benzenes: Are the Pairwise Interactions in Tri‐Substituted Methyl‐Nitro‐Benzoic Acids Still Valid?

ChemPlusChem, EarlyView.
A comprehensive thermodynamic study of nine methyl‐nitro‐benzoic acids was carried out. By combining experimental, empirical and computational methods, a consistent and reliable set of phase transition enthalpies and enthalpies of formation was established.
José M. Silva Ferraz, Vladimir N. Emel'yanenko, Dzmitry H. Zaitsau, Artemiy A. Samarov, Bruno Brunetti, Andrea Ciccioli, Stefano Vecchio Ciprioti, Sergey P. Verevkin   +7 more
wiley   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy

ChemPlusChem, Accepted Article.
The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

BASE SEQUENCE DETERMINATION IN NUCLEIC ACIDS WITH THE ELECTRON MICROSCOPE, III. CHEMISTRY AND MICROSCOPY OF GUANINE-LABELED DNA

, 1965
Evangelos N. Moudrianakis, M Beer
openalex   +1 more source