Results 161 to 170 of about 316,659 (284)

Dual Interaction of ADP Ribosylation Factor 1 with Sec7 Domain and with Lipid Membranes during Catalysis of Guanine Nucleotide Exchange [PDF]

, 1999
Sophie Béraud-Dufour, S Paris, Marc Chabre, Bruno Antonny   +3 more
openalex   +1 more source

Toxic Evaluations of Calea phyllolepis Extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate and Its In Silico Prediction of the Toxicity

Chemistry &Biodiversity, EarlyView.
In vivo and in silico toxicological effects of Calea phyllolepis extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate. ABSTRACT Medicinal plants are traditionally used in folk medicine. Still, there is a misconception about the safety/efficacy of natural treatments, which results in few studies on the toxic, genotoxic, and mutagenic potential of ...
Suele Bierhals Vencato, Guilherme Borsoi, Cleverson Feistel, Mariele Feiffer Charão, Angélica Rocha Joaquim, Jaqueline Nascimento Picada, Alexandre de Barros Falcão Ferraz   +6 more
wiley   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, EarlyView.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Properties of beta-adrenergic receptors of cultured mammalian cells. Interaction of receptors with a guanine nucleotide-binding protein in membranes prepared from L6 myoblasts and from wild-type and cyc- S49 lymphoma cells.

, 1985
Stewart N. Abramson, Perry B. Molinoff
openalex   +1 more source

A Non‐G‐Quadruplex Hemin Aptamer Forms a Better Peroxidase Mimicking DNAzyme

ChemBioChem, EarlyView.
A non‐G‐quadruplex aptamer exhibits peroxidase‐like activity when binding to hemin, forming a DNAzyme. This DNAzyme displays a pH‐rate profile similar to horseradish peroxidase, whereas a G‐quadruplex‐based DNAzyme shows an opposite trend. These two aptamers also show distinct hemin‐dependent nuclear magnetic resonance spectroscopy behaviors.
Claudia Rodríguez‐Almazán, Yunus A. Kaiyum, Philip E. Johnson, Juewen Liu   +3 more
wiley   +1 more source

Effects of Cooling on the Fluorescence of Biological Guanine Derivatives. [PDF]

, 1965
Hans Chr. Børresen, Carl‐Ivar Brändén, C. H. ISSIDORIDES, Anders Kallner   +3 more
openalex   +1 more source

Targeting G‐Rich lncRNA and its Structural Polymorphism with Selective G‐Quadruplex Ligands: An NMR Study

Chemistry – A European Journal, EarlyView.
The REG1CP‐derived RNA oligonucleotide SL15P adopts a parallel G‐quadruplex (rGQ) structure. In this study, we investigate the effect of several well‐characterized ligands, originally developed for DNA GQs, on the RNA counterpart, with the aim of evaluating their binding ability and specific binding modes.
Giuseppe Satta, Jasna Brčić, Janez Plavec   +2 more
wiley   +1 more source

Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi [PDF]

, 1988
Debra J. Gawler, Graeme Milligan, Miles D. Houslay   +2 more
openalex   +1 more source

Binding of Tetrapentylammonium to a c‐MYC G‐quadruplex Depicted through NMR and Volumetric Assessment

Chemistry – A European Journal, EarlyView.
Tetrapentylammonium forms a stable complex with c‐MYC G‐quadruplex, in which the ligand is positioned above the terminal G9‐G13‐G18‐G22 quartet of the host structure and is surrounded by the 3'‐(T23‐A24‐A25) flanking region. The binding proceeds with the release of waters of hydration and a slight decrease in the dynamics of the G‐quadruplex.
Xuan Li, Mirko Cevec, David N. Dubins, Janez Plavec, Tigran V. Chalikian   +4 more
wiley   +1 more source

DNA Noncovalent Interactions of Dinuclear η6‐Arene Ru(II) Complexes: Influence of Complex Charge and Bridging Ligand Length on DNA Binding Mode and Cytotoxic Activity

Chemistry – A European Journal, EarlyView.
A library of cationic dinuclear Ru(II)‐η⁶‐arene analogues was developed to assess how overall charge and Ru–Ru distance influence DNA binding noncovalent interactions and cytotoxicity. NMR studies showed multiple binding modes with the B‐form DNA oligonucleotide d(5΄‐CGCGAATTCGCG‐3΄)2, while the complexes displayed micromolar IC50 values against MCF‐7,
Dimitrios Thomos, Theodoros Tsolis, John C. Plakatouras, Ioannis‐Michail Chronakis, Angeliki Magklara, Achilleas Garoufis   +5 more
wiley   +1 more source