Results 121 to 130 of about 84,425 (312)

The RasGrf family of mammalian guanine nucleotide exchange factors

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2011
RasGrf1 and RasGrf2 are highly homologous mammalian guanine nucleotide exchange factors which are able to activate specific Ras or Rho GTPases. The RasGrf genes are preferentially expressed in the central nervous system, although specific expression of either locus may also occur elsewhere.
Fernández-Medarde, Alberto, Santos de Dios, Eugenio   +1 more
openaire   +4 more sources

Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility [PDF]

, 2015
Kyungmin Lee, Yuki Kobayashi, Hyunhyo Seo, Ji‐Hye Kwak, Akira Masuda, Chae‐Seok Lim, Hye‐Ryeon Lee, SukJae Joshua Kang, Pojeong Park, Su-Eon Sim, Naomi Kogo, Hiroaki Kawasaki, Bong‐Kiun Kaang, Shigeyoshi Itohara   +13 more
openalex   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover. [PDF]

J Biol Chem, 2023
Khumukcham SS, Penugurti V, Bugide S, Dwivedi A, Kumari A, Kesavan PS, Kalali S, Mishra YG, Ramesh VA, Nagarajaram HA, Mazumder A, Manavathi B.   +11 more
europepmc   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

Association of genetic variants in the Rho guanine nucleotide exchange factor AKAP13 with familial breast cancer [PDF]

, 2005
Michael Wirtenberger, Sandrine Tchatchou, Kari Hemminki, Rüdiger Klaes, Rita K. Schmutzler, Justo Lorenzo Bermejo, Bowang Chen, Barbara Wappenschmidt, Alfons Meindl, Claus R. Bartram, Barbara Burwinkel   +10 more
openalex   +1 more source

Chromosome‐scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1

Insect Science, EarlyView.
Anastrepha fraterculus sp. 1 is a major fruit fly pest in Argentina, currently controlled through chemical treatments and traps. This study aims to enhance the genomic understanding of this species to support the development of sterile insect technique as well as the use of innovative technologies.
Máximo Rivarola, Claudia A. Conte, Pierre Berube, Shu‐Huang Chen, M. Cecilia Giardini, Alejandra C. Scannapieco, Fabián H. Milla, María C. Soria, Romina M. Russo, Juan P. Wulff, Haig H. Djambazian, Rolando R. Pomar, Alfred M. Handler, Kostas Bourtzis, Ioannis Ragoussis, Silvia B. Lanzavecchia   +15 more
wiley   +1 more source

GPCRs that Rhoar the Guanine nucleotide exchange factors. [PDF]

Small GTPases, 2022
Omble A, Kulkarni K.
europepmc   +1 more source

Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling [PDF]

, 2002
Shuichi Furuta, Koichi Miura, Terry Copeland, Wei Shang, Aki Oshima, Tohru Kamata   +5 more
openalex   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source