Results 141 to 150 of about 41,746 (257)

Conformations and binding pockets of HRas and its guanine nucleotide exchange factors complexes in the guanosine triphosphate exchange process. [PDF]

J Comput Chem, 2022
Xiong Y, Zeng J, Xia F, Cui Q, Deng X, Xu X.   +5 more
europepmc   +1 more source

Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation

Journal of Integrative Plant Biology, EarlyView.
This review focuses on mitogen‐activated protein kinase (MAPK) activation and summarizes how plants regulate and integrate MAPK signaling in modulating plant immune responses. It also examines the effectors pathogens have evolved to manipulate MAPK activation and thereby inhibit plant immunity.
Guitao Zhong, Zhanchun Wang, Dingzhong Tang, Wei Wang   +3 more
wiley   +1 more source

Rab21 recruits EEA1 and competes with Rab5 for Rabex-5 activation

Frontiers in Cell and Developmental Biology
Rab5 is a key regulator of early endosomal traffic and fusion. It shares its localization and guanine nucleotide exchange factor Rabex-5 with the less characterized member of the Rab5 subfamily Rab21.
Francisco Yanguas, Cinzia Progida
doaj   +1 more source

First Tetraploa Genome and Multi‐Omics Analysis Reveal Key Plant‐Microbe‐Soil Interactions for Salt Tolerance and Yield Improvement of Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT Salinity is a major threat to global agricultural productivity of staple crops such as wheat. Although microbial‐based solutions hold promise for alleviating salinity stress, practical implementation is hindered by insufficient mechanistic characterization of bioinoculants and their interactions with plants.
Cheng‐Wei Qiu, Shuo Zhang, Zi‐Feng Gao, Zhong‐Hua Chen, Chulong Zhang, Mohamed Abdelalim Ali, Feibo Wu   +6 more
wiley   +1 more source

The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

International Journal of Biological Sciences, 2005
The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane domain (7TM) cell-surface receptors.
doaj  

Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells. [PDF]

Small GTPases, 2021
Reinhard NR, Van Der Niet S, Chertkova A, Postma M, Hordijk PL, Gadella TWJ, Goedhart J.   +6 more
europepmc   +1 more source

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.

, 1994
Growth factor-triggered activation of Ras proteins is believed to be mediated by guanine nucleotide exchange factors (CDC25/GRF and SOS1/2) that promote formation of the active Ras GTP-bound state. Although the mechanism(s) of guanine nucleotide exchange
Broek, D., Quilliam, L. A., Wei, W., Rabun, K. M., Huff, S. Y., Park, W., Der, C. J.   +6 more
core   +1 more source

Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors. [PDF]

Mol Pharmacol, 2021
Aguilar Mora FA, Musheshe N, Oun A, Buist-Homan M, Lezoualc'h F, Cheng X, Schmidt M, Moshage H.   +7 more
europepmc   +1 more source

Molecular basis for the substrate specificity of plant guanine nucleotide exchange factors for ROP

, 2009
Plant G proteins of the ROP/RAC family regulate cellular processes including cytoskeletal rearrangement in polar growth. Activation of the ROP molecular switch is triggered by guanine nucleotide exchange factors.
Fricke, Inka, Inka Fricke, Berken, Antje, Fricke, I., Antje Berken, Berken, A.   +5 more
core   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source