Results 151 to 160 of about 41,746 (257)

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Sequence‐Encoded Frustration Directs the Formation of Abridged G‐Quadruplex Architectures

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Programmable frustration reshapes the free‐energy surface (FES) of guanine‐quadruplex (G4) folding, stabilizing an abridged G4 and a G‐triplex intermediate. ABSTRACT Frustration—competing interactions that cannot be simultaneously optimized—shapes energy landscapes in proteins and soft matter, but has rarely been exploited as a programmable design ...
Yuncheng Qian, Mohamed Y. Ali, Andreas I. Karsisiotis, Paul Dillon, Scarlett A. Dvorkin, Peter A. C. McPherson, Mateus Webba da Silva   +6 more
wiley   +2 more sources

Requirements for Vav Guanine Nucleotide Exchange Factors and Rho GTPases in FcγR- and Complement-Mediated Phagocytosis

, 2006
SummaryVav guanine nucleotide exchange factors (GEFs) have been implicated in cell adhesion by integrin and immune response receptors through the regulation of Rho GTPases. Here, we examine the role of Vav and Rho GTPases in phagocytosis by using primary
Wilsbacher, Julie L., Brugge, Joan S., Amy B. Hall, M. Angelica Martinez Gakidis, Julie L. Wilsbacher, Sizhen Gao, Joan S. Brugge, Swat, Wojciech, Glogauer, Michael, Gakidis, M. Angelica Martinez, Hall, Amy B., Gao, Sizhen, Michael Glogauer, Wojciech Swat   +13 more
core   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Guanine Nucleotide Exchange Factor [PDF]

, 2020
openaire   +1 more source

Genetic Variability in OXTR Polymorphism and Infant Reactivity to Ostracism Experiences

Developmental Psychobiology, Volume 68, Issue 4, July 2026.
ABSTRACT The oxytocin system is central to regulating social behaviors, with genetic variations in the oxytocin receptor gene (OXTR), particularly the rs53576 single nucleotide polymorphism (SNP), linked to individual differences in emotional reactivity and social cognition. GG genotype carriers typically show heightened sensitivity to social dynamics,
Testa Alessia, Quadrelli Ermanno, Dall'Olio Valentina, Tizzoni Laura, Peterlongo Paolo, Bulf Hermann, Turati Chiara   +6 more
wiley   +1 more source

Regulation of Membrane Traffic by the BIG2 Member of Guanine Nucleotide Exchange Factors

, 2012
Vesicular transport is an essential cellular process that facilitates the movement of molecules within a cell. The importance of vesicular transport is highlighted by numerous human diseases that result from mutations affecting protein trafficking. The
Lowery, Jason
core  

Magnesium as a conformational gatekeeper of KRAS: Structural dynamics and therapeutic implications

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Magnesium serves as an essential cofactor for small GTPases, yet its structural role in regulating KRAS conformational dynamics and nucleotide exchange remains poorly understood. Here, we combine hydrogen–deuterium exchange mass spectrometry (HDX‐MS), native mass spectrometry, and functional assays to elucidate how Mg2+ stabilizes the KRAS ...
Bindu Y. Srinivasu, Tanvi S. Damerla, Alexander Stec, Zhiwei Zhou, John R. Engen, Kenneth D. Westover, Thomas E. Wales   +6 more
wiley   +1 more source

Expression of FERM domain including guanine nucleotide exchange factor mRNA in adult rat brain.

, 2003
FERM domain including Rho GEF (FIR) belongs to Dbl family of guanine nucleotide exchange factors and specifically activates biochemical pathways specific for Rac1. FIR was shown to regulate neurite remodeling of the embryonic neurons.
Taniguchi, Manabu, Tohyama, Masaya, Madura, Tomas, Hosokawa, Ko, Kawakita, Akihiro, Kubo, Tateki, Yamashita, Toshihide   +6 more
core   +1 more source

Targeting the Menin–KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation

European Journal of Haematology, Volume 117, Issue 1, Page 132-143, July 2026.
ABSTRACT Acute leukemias characterized by a shared epigenetic dependency on the menin–KMT2A axis rely on aberrant HOX‐driven transcriptional programs that sustain leukemic self‐renewal and impair differentiation. This dependency is most evident in KMT2A‐rearranged and NPM1‐mutated acute myeloid leukemia (AML), but also extends to other HOX‐dependent ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Mamdouh Skafi, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source