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Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer’s Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations

open access: yesThe FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Maternal choline supplementation (MCS) is utilized in the Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD). At ~6 months of age, laser capture microdissection and single population RNA‐sequencing of three hippocampal neuron populations (CA1 and CA3 pyramidal neurons and dentate gyrus granule cells) were conducted.
Melissa J. Alldred   +8 more
wiley   +1 more source

Targeting guanine nucleotide exchange factors for novel cancer drug discovery. [PDF]

open access: yesExpert Opin Drug Discov
Bannoura SF   +5 more
europepmc   +1 more source

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration. [PDF]

open access: yesJ Cell Biol, 2017
Zaritsky A   +6 more
europepmc   +1 more source

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