Results 161 to 170 of about 104,742 (325)

Small-molecule inhibitors targeting G-protein–coupled Rho guanine nucleotide exchange factors [PDF]

open access: bronze, 2013
Xun Shang   +7 more
openalex   +1 more source

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara   +3 more
wiley   +1 more source

Arf6 Guanine Nucleotide Exchange Factor Cytohesin-2 Binds to CCDC120 and Is Transported Along Neurites to Mediate Neurite Growth [PDF]

open access: hybrid, 2014
Tomohiro Torii   +7 more
openalex   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

open access: yesPediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang   +4 more
wiley   +1 more source

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

open access: yesPediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie   +5 more
wiley   +1 more source

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