Results 51 to 60 of about 52,163 (306)
, 2009 lnteraction of various guanine and related nucleotides with ribonuclease Fl was studied by means of difference absorption spectra. Spectrophotometric titrations were carried out on a total of 16 nucleotides which were classined into three groups; (A ...
Iizuka, Mari, Yoshida, Hiroshi
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Hepatology, EarlyView., 2022 Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres +21 more
wiley +1 more source
Data in Brief, 2016 The data reported herein are related to the article entitled: “The switching mechanism of the mitochondrial ADP/ATP carrier explored by free-energy landscapes” (Pietropaolo et al., 2016) [1].We report the coordinates of the ADP/ATP carrier (AAC2) in the ...
Adriana Pietropaolo +3 more
doaj +1 more source
Talanta Open, 2021 Hydrophilic interaction liquid chromatography using a zwitterionic phase, coupled with high-resolution mass spectrometry based on quadrupole and time-of-flight mass analyser (HILIC-Q-TOF-MS) is applied for the determination of four nucleobases (adenine ...
Marta Pastor-Belda +5 more
doaj +1 more source
Estudo dos mecanismos da neuroproteção promovida pela guanosina em fatias de hipocampo de ratos submetidas à privação de glicose e oxigênio [PDF]
, 2008 Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Os derivados da guanina têm sido implicados em vários efeitos extracelulares, como a modulação do sistema ...
Dal-Cim, Tharine Aparecida
core
Guanine nucleotides can activate the insulin-stimulated phosphodiesterase in liver plasma membranes
, 1983 The insulin-stimulated cyclic AMP phosphodiesterase from liver plasma membranes is shown to be activated upon incubation with guanine nucleotides in the presence of ATP. The non-hydrolysable analogue of ATP, adenylyl imidodiphosphate failed to substitute
Miles D. Houslay +5 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase
Cell Reports, 2017 Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies have demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleotides.
Natasha Emmanuel +9 more
doaj +1 more source
A metazoan/plant-like capping enzyme and cap modified nucleotides in the unicellular eukaryote Trichomonas vaginalis. [PDF]
PLoS Pathogens, 2010 The cap structure of eukaryotic messenger RNAs is initially elaborated through three enzymatic reactions: hydrolysis of the 5'-triphosphate, transfer of guanosine through a 5'-5' triphosphate linkage and N7-methylation of the guanine cap.
Augusto Simoes-Barbosa +2 more
doaj +1 more source