Results 41 to 50 of about 150,931 (301)

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

eLife, 2020
We report the in vivo regulation of Inosine-5´-monophosphate dehydrogenase 1 (IMPDH1) in the retina. IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP, GDP and GTP.
Anna Plana-Bonamaisó, Santiago López-Begines, David Fernández-Justel, Alexandra Junza, Ariadna Soler-Tapia, Jordi Andilla, Pablo Loza-Alvarez, Jose Luis Rosa, Esther Miralles, Isidre Casals, Oscar Yanes, Pedro de la Villa, Ruben M Buey, Ana Méndez   +13 more
doaj   +1 more source

Nucleotide discrimination with DNA immobilized in the MspA nanopore. [PDF]

PLoS ONE, 2011
Nanopore sequencing has the potential to become a fast and low-cost DNA sequencing platform. An ionic current passing through a small pore would directly map the sequence of single stranded DNA (ssDNA) driven through the constriction.
Elizabeth A Manrao, Ian M Derrington, Mikhail Pavlenok, Michael Niederweis, Jens H Gundlach   +4 more
doaj   +1 more source

Subcellular compartmentation of guanine nucleotides and functional relationships between the adenine and guanine nucleotide systems in isolated hepatocytes [PDF]

FEBS Letters, 1979
The subcellular compartmentation of adenine nucleotides between the mitochondria and the cytosol has been clearly demonstrated by the use of different cell fractionation techniques [ 1,2]. However, data concerning the subcellular distribution of guanine nucleotides are not available.
Kleineke, Jochen, Düls, Christel, Söling, Hans-Dieter   +2 more
openaire   +2 more sources

Chasing Particularities of Guanine- and Cytosine-Rich DNA Strands

Molecules, 2020
By substitution of natural nucleotides by their abasic analogs (i.e., 1′,2′-dideoxyribose phosphate residue) at critically chosen positions within 27-bp DNA constructs originating from the first intron of N-myc gene, we hindered hybridization
Marko Trajkovski, Janez Plavec
doaj   +1 more source

Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB [PDF]

Journal of Biological Chemistry, 2013
Small G-proteins of the Ras superfamily control the temporal and spatial coordination of intracellular signaling networks by acting as molecular on/off switches. Guanine nucleotide exchange factors (GEFs) regulate the activation of these G-proteins through catalytic replacement of GDP by GTP.
Guo, Zhong, Hou, Xiaomin, Goody, Roger S., Itzen, Aymelt   +3 more
openaire   +7 more sources

An evolutionary ratchet leading to loss of elongation factors in eukaryotes [PDF]

, 2014
Background The GTPase eEF1A is the eukaryotic factor responsible for the essential, universal function of aminoacyl-tRNA delivery to the ribosome.
Kamenski, Piotr, Atkinson, Gemma C.,, Atkinson, Gemma C., Soosaar, Axel, Hauryliuk, Vasili,, Ivan Chicherin, Martin Carr, Tenson, Tanel,, Vasili Hauryliuk, Carr, Martin, Tanel Tenson, Kamenski, Piotr,, Kuzmenko, Anton, Hauryliuk, Vasili, Tenson, Tanel, Kuzmenko, Anton,, Chicherin, Ivan,, Carr, Martin,, Piotr Kamenski, Gemma C Atkinson, Soosaar, Axel,, Anton Kuzmenko, Lund University., Axel Soosaar, Chicherin, Ivan   +24 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The role of guanine nucleotides in protein biosynthesis

Biophysical Journal, 1978
It is not possible to select one competing substrate molecule over another one when the selection system is at equilibrium. Therefore, it is convenient to view all substrate selections as transport phenomena. The requirement for a displacement from equilibrium to effect a substrate selection can be met in different ways. One particularly convenient way
openaire   +2 more sources

Trapp Stimulates Guanine Nucleotide Exchange on Ypt1p [PDF]

The Journal of Cell Biology, 2000
TRAPP, a novel complex that resides on early Golgi, mediates the targeting of ER-to-Golgi vesicles to the Golgi apparatus. Previous studies have shown that YPT1, which encodes the small GTP-binding protein that regulates membrane traffic at this stage of the secretory pathway, interacts genetically with BET3 and BET5.
W, Wang, M, Sacher, S, Ferro-Novick
openaire   +2 more sources