Results 21 to 30 of about 52,163 (306)

Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain

Nature Communications, 2020
Trypanosoma brucei guanosine 5′-monophosphate reductase (TbGMPR) catalyses the conversion of GMP to inosine 5′-monophosphate and contains a cystathionine-β-synthase (CBS) domain. Here the authors combine X-ray crystallography and kinetic measurements and
Akira Imamura, Tetsuya Okada, Hikaru Mase, Takuya Otani, Tomoka Kobayashi, Manatsu Tamura, Bruno Kilunga Kubata, Katsuaki Inoue, Robert P. Rambo, Susumu Uchiyama, Kentaro Ishii, Shigenori Nishimura, Takashi Inui   +12 more
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GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity

iScience, 2021
Summary: eIF2B is the guanine nucleotide exchange factor (GEF) required for cytoplasmic protein synthesis initiation in eukaryotes and its regulation within the integrated stress response (ISR).
Christopher J. Kershaw, Martin D. Jennings, Francesco Cortopassi, Margherita Guaita, Hawra Al-Ghafli, Graham D. Pavitt   +5 more
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Kinetics of the interactions between yeast elongation factors 1A and 1Bα, guanine nucleotides, and aminoacyl-tRNA. [PDF]

, 2007
The interactions of elongation factor 1A (eEF1A) from Saccharomyces cerevisiae with elongation factor 1Bα (eEF1Bα), guanine nucleotides, and aminoacyl-tRNA were studied kinetically by fluorescence stopped-flow.
Schuemmer, T., Stromgaard, Anne, Kinzy, Terri Goss, Str⌀mgaard, Anne, Gromadski, K. B., Rodnina, Marina, Stromgaard, A., Knudsen, C. R., Rodnina, M., Knudsen, Charlotte R., Gromadski, Kirill B., Rodnina, M. V., Schümmer, Tobias, Gromadski, K., Knudsen, C., Rodnina, Marina V., Schuemmer, Tobias, Kinzy, T. G., Kinzy, T.   +18 more
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The regulation of adenylate cyclase by guanine nucleotides in Dictyostelium discoideum membranes [PDF]

, 1987
Extracellular cAMP induces the activation of adenylate cyclase in Dictyostelium discoideum cells. Conditions for both stimulation and inhibition of adenylate cyclase by guanine nucleotides in membranes are reported. Stimulation and inhbition were induced
Janssens, Pim M.W., Haastert, Peter J.M. van,, B. Ewa Snaar-jagalska, Snaar-Jagalska, B. Ewa,, Peter J. M. Van Haastert, Pim M. W. Janssens, Janssens, Pim M.W.,, Haastert, Peter J.M. van, Snaar-Jagalska, B. Ewa   +8 more
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Short Term Effect of Caffeine on Purine, Pyrimidine and Pyridine Metabolism in Rice () Seedlings

Natural Product Communications, 2015
As part of our studies on the physiological and ecological function of caffeine, we investigated the effect of exogenously supplied caffeine on purine, pyrimidine and pyridine metabolism in rice seedlings.
Wei-Wei Deng, Riko Katahira, Hiroshi Ashihara   +2 more
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Effective and repeatable chromatographic separation of 5 nucleotides in infant formula milk powder by ion-pair high-performance liquid chromatography–ultraviolet

Journal of Dairy Science, 2022
: A robust method using HPLC-UV was developed to improve the accuracy and repeatability of a quantitative method to detect 5 nucleotides (cytidine-monophosphate, uridine monophosphate, adenosine monophosphate, guanine monophosphate, and inosine ...
Yuanjia Chen, Lin Luo, Peiyan Feng, Baojun Xu, Xiaoqun Wei   +4 more
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Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation

Nature Communications, 2016
Specialized translation elongation factors (eEFSec and SelB) promote selenocysteine incorporation into proteins. Here, the authors report the structure of human eEFSec, examine its interactions with guanine nucleotides, and propose a non-canonical ...
Malgorzata Dobosz-Bartoszek, Mark H. Pinkerton, Zbyszek Otwinowski, Srinivas Chakravarthy, Dieter Söll, Paul R. Copeland, Miljan Simonović   +6 more
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An integrated approach to evaluate acetamiprid-induced oxidative damage to tRNA in human cells based on oxidized nucleotide and tRNA profiling

Environment International, 2023
Acetamiprid is poisonous to mammals due to severe acetamiprid-induced oxidative stress that could cause mitochondrial dysfunctions, lipid and protein oxidation, inflammation, apoptosis, and DNA damage.
Hui-Xia Zhang, Dian Yu, Jian-Feng Sun, Ling Zeng, Cai-Yun Wang, Li-Ping Bai, Guo-Yuan Zhu, Zhi-Hong Jiang, Wei Zhang   +8 more
doaj   +1 more source

Chromatin structure and context-dependent sequence features control prime editing efficiency

Frontiers in Genetics, 2023
Prime editing (PE) is a highly versatile CRISPR–Cas9 genome editing technique. The current constructs, however, have variable efficiency and may require laborious experimental optimization.
Somang Kim, Somang Kim, Jimmy B. Yuan, Jimmy B. Yuan, Wendy S. Woods, Destry A. Newton, Pablo Perez-Pinera, Pablo Perez-Pinera, Pablo Perez-Pinera, Pablo Perez-Pinera, Pablo Perez-Pinera, Jun S. Song, Jun S. Song, Jun S. Song, Jun S. Song, Jun S. Song   +15 more
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Dampening of neurotransmitter action: molecular similarity within the melatonin structure

Endocrine Regulations, 2018
Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides.
Williams Wynford R.
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