Results 21 to 30 of about 150,931 (301)

BiAPoL/guanine-crystal-analysis: 0.0.2

, 2023
What's Changed Execution from folder by @marabuuu in https://github.com/BiAPoL/guanine-crystal-analysis/pull/2 Documentation by @marabuuu in https://github.com/BiAPoL/guanine-crystal-analysis/pull/5 Execution from folder by @marabuuu in https://github ...
Mara Lampert, Robert Haase
core   +1 more source

Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP

Bio-Protocol, 2018
GTPases are molecular switches that cycle between the inactive GDP-bound state and the active GTP-bound state. GTPases exchange nucleotides either by its intrinsic nucleotide exchange or by interaction with guanine nucleotide exchange factors (GEFs ...
Tomoharu Kanie, Peter Jackson
doaj   +1 more source

Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain

Nature Communications, 2020
Trypanosoma brucei guanosine 5′-monophosphate reductase (TbGMPR) catalyses the conversion of GMP to inosine 5′-monophosphate and contains a cystathionine-β-synthase (CBS) domain. Here the authors combine X-ray crystallography and kinetic measurements and
Akira Imamura, Tetsuya Okada, Hikaru Mase, Takuya Otani, Tomoka Kobayashi, Manatsu Tamura, Bruno Kilunga Kubata, Katsuaki Inoue, Robert P. Rambo, Susumu Uchiyama, Kentaro Ishii, Shigenori Nishimura, Takashi Inui   +12 more
doaj   +1 more source

GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity

iScience, 2021
Summary: eIF2B is the guanine nucleotide exchange factor (GEF) required for cytoplasmic protein synthesis initiation in eukaryotes and its regulation within the integrated stress response (ISR).
Christopher J. Kershaw, Martin D. Jennings, Francesco Cortopassi, Margherita Guaita, Hawra Al-Ghafli, Graham D. Pavitt   +5 more
doaj   +1 more source

Regulation of phosphoinositide breakdown by guanine nucleotides

Life Sciences, 1986
Phosphoinositide hydrolysis is coupled to receptor systems involved in the elevation of cytosolic Ca2+ and activation of protein kinase C. In cell-free systems, guanine nucleotides are required to transduce the effects of receptor activation to phosphoinositide breakdown.
I, Litosch, J N, Fain
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1-expressing leukaemia cells via guanine nucleotide depletion. [PDF]

Mol Oncol
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Yagüe-Capilla M, Dirks C, Eiden C, Fesenmayer SK, Hormann FM, Klootsema Y, Lilienthal I, Zhang SM, Herold N, Rudd SG.   +9 more
europepmc   +2 more sources

Kinetics of the interactions between yeast elongation factors 1A and 1Bα, guanine nucleotides, and aminoacyl-tRNA. [PDF]

, 2007
The interactions of elongation factor 1A (eEF1A) from Saccharomyces cerevisiae with elongation factor 1Bα (eEF1Bα), guanine nucleotides, and aminoacyl-tRNA were studied kinetically by fluorescence stopped-flow.
Schuemmer, T., Stromgaard, Anne, Kinzy, Terri Goss, Str⌀mgaard, Anne, Gromadski, K. B., Rodnina, Marina, Stromgaard, A., Knudsen, C. R., Rodnina, M., Knudsen, Charlotte R., Gromadski, Kirill B., Rodnina, M. V., Schümmer, Tobias, Gromadski, K., Knudsen, C., Rodnina, Marina V., Schuemmer, Tobias, Kinzy, T. G., Kinzy, T.   +18 more
core   +1 more source

Short Term Effect of Caffeine on Purine, Pyrimidine and Pyridine Metabolism in Rice () Seedlings

Natural Product Communications, 2015
As part of our studies on the physiological and ecological function of caffeine, we investigated the effect of exogenously supplied caffeine on purine, pyrimidine and pyridine metabolism in rice seedlings.
Wei-Wei Deng, Riko Katahira, Hiroshi Ashihara   +2 more
doaj   +1 more source

The regulation of adenylate cyclase by guanine nucleotides in Dictyostelium discoideum membranes [PDF]

, 1987
Extracellular cAMP induces the activation of adenylate cyclase in Dictyostelium discoideum cells. Conditions for both stimulation and inhibition of adenylate cyclase by guanine nucleotides in membranes are reported. Stimulation and inhbition were induced
Janssens, Pim M.W., Haastert, Peter J.M. van,, B. Ewa Snaar-jagalska, Snaar-Jagalska, B. Ewa,, Peter J. M. Van Haastert, Pim M. W. Janssens, Janssens, Pim M.W.,, Haastert, Peter J.M. van, Snaar-Jagalska, B. Ewa   +8 more
core   +2 more sources

Guanine nucleotides in ischaemic heart [PDF]

, 1994
In isolated perfused rat hearts the concentration of guanine nucleotides following periods of global no-flow ischaemia and reperfusion were found to parallel those of adenine nucleotides under all conditions tested.
Stanley, Peter Graham
core   +1 more source