The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases. [PDF]
Protein Sci, 2022 Inosine 5′‐monophosphate dehydrogenase (IMPDH) is an evolutionarily conserved enzyme that mediates the first committed step in de novo guanine nucleotide biosynthetic pathway. It is an essential enzyme in purine nucleotide biosynthesis that modulates the
Buey RM +3 more
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Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
Nature Communications, 2021 Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ...
Hongxu Ding +4 more
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Transglutaminase 5 is regulated by guanine–adenine nucleotides [PDF]
Biochemical Journal, 2004 Transglutaminases (TGases) are Ca2+-dependent enzymes capable of catalysing transamidation of glutamine residues to form intermolecular isopeptide bonds. Nine distinct TGases have been described in mammals, and two of them (types 2 and 3) are regulated by GTP/ATP. TGase2 hydrolyses GTP and is therefore a bifunctional enzyme.
CANDI, ELEONORA +10 more
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Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways. [PDF]
PLoS Pathogens, 2010 Riboswitches are regulatory elements modulating gene expression in response to specific metabolite binding. It has been recently reported that riboswitch agonists may exhibit antimicrobial properties by binding to the riboswitch domain.
Jérôme Mulhbacher +5 more
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Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir
The Innovation, 2021 Summary: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into an unprecedented global pandemic. Nucleoside analogs, such as Remdesivir and Favipiravir, can serve as the first-line broad-spectrum antiviral drugs ...
Qi Peng +7 more
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Frontiers in Genetics, 2023 Introduction: Essential genes are essential for the survival of various species. These genes are a family linked to critical cellular activities for species survival.
Ranjeet Kumar Rout +7 more
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Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]
, 2000 The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner +3 more
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Essential role of GTP in epinephrine stimulation of human fat cell adenylate cyclase
Journal of Lipid Research, 1981 The activity of epinephrine-sensitive adenylate cyclase of human fat cell ghosts is markedly enhanced by the GTP analog 5'-guanylyl-imidodiphosphate (GMP-P(NH)P), but a similar effect of GTP itself has not been heretofore demonstrable.
M S Katz +3 more
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Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites
Guangdong nongye kexue, 2023 Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU +7 more
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Mitochondrial metabolism of guanine nucleotides possible role of guanosine [PDF]
, 1989 The catabolism of intramitochondrial guanine nucleotides was examined. During 30 min incubation of rat liver mitochondria at 37°C in the presence of oligomycin and carboxyatractyloside, guanine and xanthine were formed and appeared in the medium.
Tikhonov, Yuri V. +13 more
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