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Effects and interactive effects of high-altitude environment on metabolism in normal and diabetic populations: a comparative metabolomics study [PDF]
Frontiers in EndocrinologyIntroductionHigh-altitude environments impose unique physiological stresses that may alter metabolic dysregulation in individuals with type 2 diabetes mellitus (T2DM).
Jing Shi +11 more
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G-Quadruplex Guanosine Gels and Single Walled Carbon Nanotubes [PDF]
Molecules, 2013 Solubilization of single walled carbon nanotubes (SWNTs) in aqueous gel phases formed by reversible, G-quadruplex self-assembly of guanosine monophosphate (GMP) alone or with guanosine (Guo) is described.
Yuehua Yu +3 more
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Guanosine protects against glycerol-induced acute kidney injury via up-regulation of the klotho gene [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Acute Kidney Injury (AKI) is characterized by a rapid and reversible decline in renal function with a rapid decrease in Glomerular Filtration Rate (GFR), which is associated with high mortality. Rhabdomyolysis accounts for 10–40% of AKI, to
Rasha Ahmed +5 more
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Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma
Metabolites, 2021 In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling +9 more
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Frontiers in Pharmacology, 2021 Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy.
Natale Belluardo +13 more
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Metabolites, 2022 Alzheimer’s disease (AD) is a progressive neurodegenerative illness responsible for cognitive impairment and dementia. Accumulation of amyloid-beta (Aβ) peptides in neurons and synapses causes cell metabolism to unbalance, and the production of reactive ...
Victor Coelho +5 more
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Crystal structure of the nucleoside 2′-deoxyguanosine dimethyl sulfoxide disolvate
Acta Crystallographica Section E: Crystallographic Communications, 2023 The title compound, C10H13N5O4·2C2H6OS, which is of interest with respect to its biological activity, at 183 K has orthorhombic (P212121) crystal symmetry. The structure displays a network of intermolecular N—H...N, N—H...O and O—H...O hydrogen bonds. 2′-
Bernhard Spingler
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Electrocatalytic Oxidation of Guanine, Guanosine, and Guanosine Monophosphate [PDF]
Biophysical Journal, 2007 The electrochemical behavior of guanine, guanosine, and guanosine monophosphate (GMP) at redox polymer film modified indium tin oxide electrodes is examined by voltammetry and redox titration. Utilizing the redox polymer-coated electrodes as indicator electrodes, a new method for measuring the oxidation potentials, based on monitoring their catalytic ...
Xie, H., Yang, D., Heller, A., Gao, Z.
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Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model
Frontiers in Psychiatry, 2021 Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants with higher effectiveness.
Roberto Farina Almeida +17 more
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Cell Reports Physical Science, 2021 Summary: Extending the structural hierarchy and complexity through small-molecular self-assembly is a powerful way to obtain large discrete, functional molecular architecture.
Ying He +8 more
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