On the epigenetic role of guanosine oxidation
Redox Biology, 2020 Chemical modifications of DNA and RNA regulate genome functions or trigger mutagenesis resulting in aging or cancer. Oxidations of macromolecules, including DNA, are common reactions in biological systems and often part of regulatory circuits rather than
Marco Giorgio +4 more
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Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment [PDF]
Cell Death and DiseaseGlioblastoma (GBM) is among the deadliest cancers, characterized by poor prognosis and median survival of 12–15 months post-diagnosis. Despite aggressive therapeutic regimens, GBM treatment is still an unmet clinical need due to heterogeneity ...
Simona D’Aprile +17 more
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Whole-genome analysis of Bacillus paranthracis YC06 isolated from healthy individual feces for biodegrading inosine and guanosine [PDF]
BMC MicrobiologyThe overproduction of uric acid, driven by its key precursors (inosine and guanosine), leads to hyperuricemia, a metabolic disorder associated with severe complications such as gout and renal dysfunction.
Xiaoyu Cao +3 more
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Guanosine enhances the bactericidal effect of ceftiofur sodium on Streptococcus suis by activating bacterial metabolism [PDF]
VirulenceThe emergence and rapid development of antibiotic resistance poses a serious threat to global public health. Streptococcus suis (S. suis) is an important zoonotic pathogen, and the development of its antibiotic resistance has made the infections ...
Yue Dong +12 more
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The Isolation of Guanosine Tetraphosphate from Commercially Available Preparations of Guanosine Triphosphate [PDF]
Journal of Biological Chemistry, 1965 Jared Gardner, Mahlon B. Hoagland
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Guanosine protects against glycerol-induced acute kidney injury via up-regulation of the klotho gene [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Acute Kidney Injury (AKI) is characterized by a rapid and reversible decline in renal function with a rapid decrease in Glomerular Filtration Rate (GFR), which is associated with high mortality. Rhabdomyolysis accounts for 10–40% of AKI, to
Rasha Ahmed +5 more
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Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma
Metabolites, 2021 In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling +9 more
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Electrocatalytic Oxidation of Guanine, Guanosine, and Guanosine Monophosphate [PDF]
Biophysical Journal, 2007 The electrochemical behavior of guanine, guanosine, and guanosine monophosphate (GMP) at redox polymer film modified indium tin oxide electrodes is examined by voltammetry and redox titration. Utilizing the redox polymer-coated electrodes as indicator electrodes, a new method for measuring the oxidation potentials, based on monitoring their catalytic ...
Xie, H., Yang, D., Heller, A., Gao, Z.
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Frontiers in Pharmacology, 2021 Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy.
Natale Belluardo +13 more
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