Results 1 to 10 of about 194,604 (252)
Adenosine A1-A2A Receptor-Receptor Interaction: Contribution to Guanosine-Mediated Effects [PDF]
Cells, 2019 Guanosine, a guanine-based purine nucleoside, has been described as a neuromodulator that exerts neuroprotective effects in animal and cellular ischemia models.
D. Lanznaster +8 more
semanticscholar +3 more sources
Frontiers in Pharmacology, 2018 The extracellular guanosine 5′-triphosphate, GTP, has been demonstrated to be an enhancer of myogenic cell differentiation in a murine cell line, not yet in human muscle cells.
Tiziana Pietrangelo +9 more
doaj +2 more sources
Guanosine enhances the bactericidal effect of ceftiofur sodium on Streptococcus suis by activating bacterial metabolism [PDF]
VirulenceThe emergence and rapid development of antibiotic resistance poses a serious threat to global public health. Streptococcus suis (S. suis) is an important zoonotic pathogen, and the development of its antibiotic resistance has made the infections ...
Yue Dong +12 more
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Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment [PDF]
Cell Death and DiseaseGlioblastoma (GBM) is among the deadliest cancers, characterized by poor prognosis and median survival of 12–15 months post-diagnosis. Despite aggressive therapeutic regimens, GBM treatment is still an unmet clinical need due to heterogeneity ...
Simona D’Aprile +17 more
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Molecules, 2013 In the past 30 years, only three natural products have been sources of new drugs with antiplatelet activity. In this study, we have demonstrated for the first time that guanosine from Solanum lycopersicum possesses antiplatelet (secretion, spreading ...
Iván Palomo +5 more
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The potential therapeutic effect of guanosine after cortical focal ischemia in rats.
PLoS ONE, 2014 Background and purposeStroke is a devastating disease. Both excitotoxicity and oxidative stress play important roles in ischemic brain injury, along with harmful impacts on ischemic cerebral tissue. As guanosine plays an important neuroprotective role in
Gisele Hansel +7 more
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Efficient production of guanosine in Escherichia coli by combinatorial metabolic engineering [PDF]
Microbial Cell FactoriesBackground Guanosine is a purine nucleoside that is widely used as a raw material for food additives and pharmaceutical products. Microbial fermentation is the main production method of guanosine. However, the guanosine-producing strains possess multiple
Kun Zhang +5 more
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Guanosine protects against glycerol-induced acute kidney injury via up-regulation of the klotho gene [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Acute Kidney Injury (AKI) is characterized by a rapid and reversible decline in renal function with a rapid decrease in Glomerular Filtration Rate (GFR), which is associated with high mortality. Rhabdomyolysis accounts for 10–40% of AKI, to
Rasha Ahmed +5 more
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Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma
Metabolites, 2021 In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling +9 more
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Frontiers in Pharmacology, 2021 Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy.
Natale Belluardo +13 more
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