Results 91 to 100 of about 236,112 (356)

Azaporphyrinoid‐Based Photo‐ and Electroactive Architectures for Advanced Functional Materials

Advanced Materials, EarlyView.
A long‐standing collaboration between the Torres and Guldi groups has yielded diverse azaporphyrinoid‐based donor‐acceptor nanohybrids with promising applications in solar energy conversion. This conspectus highlights key molecular platforms and structure‐function relationships that govern light and charge management, supporting the rational design of ...
Jorge Labella, Kobra Azizi, Dirk M. Guldi, Tomás Torres   +3 more
wiley   +1 more source

Influencing factors and mechanisms of guanosine degradation by Lactiplantibacillus plantarum ST-11 from red sour soup [PDF]

Zhongguo niangzao
Using a guanosine-degrading strain ST-11 isolated from the naturally fermented red sour soup in Guizhou as the research object, the strain was identified through morphological observation and molecular biology techniques, and the degradation ability of ...
ZHOU Qingli, ZHANG Jiying, ZHOU Yan
doaj   +1 more source

Common Mitochondrial DNA Mutations Generated through DNA-Mediated Charge Transport [PDF]

, 2009
Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)2bpy]Cl3 (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to ...
Barton, Jacqueline K., Davis, Molly L., Merino, Edward J.   +2 more
core   +2 more sources

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Biogenic Next‐Gen CPL Emitters: Strategies with Proteins, Polysaccharides, and Nucleotides

Advanced Optical Materials, EarlyView.
Biogenic molecules such as proteins, peptides, saccharides, and DNA can act as natural scaffolds for generating circularly polarized luminescence (CPL). This review highlights recent strategies exploiting these inherently chiral frameworks to achieve light emission with controllable handedness under unpolarized excitation, bridging biological ...
Ricardo Chavez‐Jimenez, Gustavo González‐Gaitano, Julio Fernandez‐Cestau, Mattia Nieddu, Juan Pablo Fuenzalida‐Werner   +4 more
wiley   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Guanosine Mechanisms of Action: Toward Molecular Targets

Frontiers in Pharmacology, 2021
Caio M. Massari, Mariachiara Zuccarini, Patrizia Di Iorio, Carla I. Tasca   +3 more
doaj   +1 more source

Guanosine enhances the bactericidal effect of ceftiofur sodium on Streptococcus suis by activating bacterial metabolism

Virulence
The emergence and rapid development of antibiotic resistance poses a serious threat to global public health. Streptococcus suis (S. suis) is an important zoonotic pathogen, and the development of its antibiotic resistance has made the infections ...
Yue Dong, Xiaona Liu, Shanshan Xiong, Mingyu Cao, Haojie Wu, Long Chen, Mengmeng Zhao, Yadan Zheng, Zhiyun Zhang, Yanyan Liu, Yanhua Li, Qianwei Qu, Chunliu Dong   +12 more
doaj   +1 more source

Nonenzymatic Formation of Guanosine 3′ : 5′-Monophosphate from Guanosine Triphosphate

Journal of Biological Chemistry, 1974
Abstract We observed the nonenzymatic formation of guanosine 3' : 5'-monophosphate (cyclic GMP) from GTP. The reaction was dependent upon heat and was accelerated by divalent cations and creatine phosphate. The formation of cyclic GMP was greater with increased incubation time, temperature, GTP concentration, and pH. All of the divalent cations tested (
H, Kimura, F, Murad
openaire   +2 more sources

TET2 inhibits differentiation of embryonic stem cells but does not overcome methylation-induced gene silencing [PDF]

, 2014
TET2 is a methylcytosine dioxygenase that is frequently mutated in myeloid malignancies, notably myelodysplasia and acute myeloid leukemia. TET2 catalyses the conversion of 5′-methylcytosine to 5′-hydroxymethylcytosine within DNA and has been implicated ...
Chevassut, Timothy, Norman, Louis, Tarrant, Paul   +2 more
core   +3 more sources