Results 81 to 90 of about 163,448 (315)

Guanosine Mechanisms of Action: Toward Molecular Targets

Frontiers in Pharmacology, 2021
Caio M. Massari, Mariachiara Zuccarini, Patrizia Di Iorio, Carla I. Tasca   +3 more
doaj   +1 more source

Eine Universelle Nukleosid‐zu‐Nukleosid‐5′‐triphosphat‐Enzymkaskade angetrieben durch Polyphosphat

Angewandte Chemie, EarlyView.
Nukleosid‐5′‐Triphosphate (NTPs) sind wichtige Bausteine für Nukleinsäuren. Ihre chemische Synthese ist aufgrund der geringen Ausbeute der 5′‐Triphosphorylierungsreaktion nur wenig effizient. Wir stellen hier eine universelle, durch Polyphosphat angetriebene Zwei‐Enzym‐Kaskade vor, die eine direkte Phosphorylierung von Nukleosiden zu NTPs ermöglicht ...
Jonathan P. Suess, Nicolas V. Cornelissen   +1 more
wiley   +1 more source

Electroenzymatic CO2 Fixation

Angewandte Chemie International Edition, EarlyView.
Electroenzymatic CO2 fixation enables energy‐efficient, highly selective synthesis of complex molecules. Unlocking its full potential requires fundamental understanding of electrode‐coupled reductases and carboxylases. This review critically discusses available enzymes, product scope, and key thermodynamic and kinetic considerations, highlighting ...
Leonardo Castañeda‐Losada, Michael Richter, Christophe Léger, Vincent Fourmond, Nicolas Plumeré   +4 more
wiley   +1 more source

A Universal Nucleoside‐to‐Nucleoside‐5′‐Triphosphate Enzyme Cascade Driven by Polyphosphate

Angewandte Chemie International Edition, EarlyView.
Nucleoside‐5′‐triphosphates (NTPs) are essential components for the generation of nucleic acids, yet their chemical synthesis is hindered by the low yield of nucleoside phosphorylation. Here, we present a universal, two‐enzyme nucleoside‐to‐NTP cascade that is driven by polyphosphate.
Jonathan P. Suess, Nicolas V. Cornelissen   +1 more
wiley   +1 more source

Raising the Guanosine-Based Molecules as Regulators of Excitable Tissues by the Exosomal-Vehiculated Signaling

Frontiers in Pharmacology, 2021
Tiziana Pietrangelo, Tiziana Pietrangelo
doaj   +1 more source

Efficient production of guanosine in Escherichia coli by combinatorial metabolic engineering

Microbial Cell Factories
Background Guanosine is a purine nucleoside that is widely used as a raw material for food additives and pharmaceutical products. Microbial fermentation is the main production method of guanosine. However, the guanosine-producing strains possess multiple
Kun Zhang, Mengxing Qin, Yu Hou, Wenwen Zhang, Zhenyu Wang, Hailei Wang   +5 more
doaj   +1 more source

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands

Cell Reports, 2018
Summary: Toll-like receptor 7 (TLR7) is an innate immune receptor for single-stranded RNA (ssRNA) and has important roles in infectious diseases. We previously reported that TLR7 shows synergistic activation in response to two ligands, guanosine and ...
Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, Masato Taoka, Yoshio Yamauchi, Ryota Sato, Nikunj M. Shukla, Sunil A. David, Toshiaki Isobe, Kensuke Miyake, Toshiyuki Shimizu   +10 more
doaj   +1 more source

Anti-proliferative Activity of N-Heterocyclic Carbenes Derived from Guanosine [PDF]

, 2018
Maria Inês P. S. Leitão, Federico Herrera, Ana Petronilho   +2 more
openalex   +1 more source

ppGpp Controls Global Gene Expression in Light and in Darkness in S. elongatus

Cell Reports, 2017
The bacterial and plant stringent response involves production of the signaling molecules guanosine tetraphosphate and guanosine pentaphosphate ((p)ppGpp), leading to global reorganization of gene expression.
Anna M. Puszynska, Erin K. O’Shea
doaj   +1 more source

The Relationship of Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase-Stimulator of the Interferon Gene Pathway With Other Immunity Signaling Pathways in Apoptosis [PDF]

, 2023
Navid Shomali
openalex   +1 more source