Results 41 to 50 of about 236,112 (356)

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice. [PDF]

PLoS ONE, 2015
Metabolic homeostasis is critical for all biological processes in the brain. The metabolites are considered the best indicators of cell states and their rapid fluxes are extremely sensitive to cellular changes.
Xi Chen, Chengsong Xie, Lixin Sun, Jinhui Ding, Huaibin Cai   +4 more
doaj   +1 more source

Spontaneous assembly of an organic-inorganic nucleic acid Z-DNA double-helix structure [PDF]

, 2017
Herein, we report a hybrid polyoxometalate organic–inorganic compound, Na2[(HGMP)2Mo5O15]⋅7 H2O (1; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally ...
Albrecht, Arnott, Barnes, Braga, Cafferty, Cairns-Smith, Carraro, Champ, Cooper, Crick, Ellena, Hill, Humphrey, Inoue, Kim, Kulikov, Kwak, Li, Maehigashi, Martins, Murayama, Nordén, Parker, Powner, Rich, Ritson, Soghomonian, Strandberg, Sun, Tang, Van Hecke, Vasconcelos, Voet, Wang, Wong, Yamase, Yu   +36 more
core   +1 more source

Modulation of phenylalanine and tyrosine concentrations by ischemia and guanosine in neuronal PC12 cells

Pteridines, 2013
Survival of neurons is dependent on the presence of trophic and non-trophic factors. We have previously observed the protective capacity of purine nucleosides in hypoxic neuronal cell cultures.
Thauerer Bettina, Geisler Simon, Fuchs Dietmar, Baier-Bitterlich Gabriele   +3 more
doaj   +1 more source

Biofilm reduction, in-vitro cytotoxicity and computational drug-likeness of selected phytochemicals to combat multidrug-resistant bacteria

Scientific African, 2023
Multidrug-resistant (MDR) bacteria in biofilms are frequently linked with persistent infections across healthcare settings, due to their virulence factors.
Itumeleng T. Baloyi, Idowu J. Adeosun, Francesca Bonvicini, Sekelwa Cosa   +3 more
doaj   +1 more source

Rho GTPases in Skeletal Muscle Development and Homeostasis

Cells, 2021
Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range
Sonia Rodríguez-Fdez, Xosé R. Bustelo
doaj   +1 more source

Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation [PDF]

, 2015
In rodent models of Parkinsons disease (PD), dopamine neuron loss is accompanied by increased expression of angiotensin II (AngII), its type 1 receptor (AT1), and NADPH oxidase (Nox) in the nigral dopamine neurons and microglia.
Aboud, O, Biedermann, J, Gentleman, SM, Griffin, WS, Mrak, RE, Palmer, QD, Zawada, WM   +6 more
core   +2 more sources

Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress. [PDF]

, 2014
The specific mechanisms underlying paraquat (PQ)-induced lung injury remain unknown, which limits understanding of its cytotoxic potential. Although oxidative stress has been established as an important mechanism underlying PQ toxicity, multiple ...
Cao, Yu, He, Yarong, Jiang, Yaowen, Lau, Wayne Bond, Liu, Peng, Yao, Rong, Ye, Lei, Zeng, Zhi, Zheng, Zhijie, Zhou, Yaxiong   +9 more
core   +2 more sources

Guanosine behind the scene [PDF]

Journal of Neurochemistry, 2013
Read the full article ‘Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions’ on doi: 10.1111/jnc ...
openaire   +2 more sources

Cladribine Analogues via O6-(Benzotriazolyl) Derivatives of Guanine Nucleosides

Molecules, 2015
Cladribine, 2-chloro-2′-deoxyadenosine, is a highly efficacious, clinically used nucleoside for the treatment of hairy cell leukemia. It is also being evaluated against other lymphoid malignancies and has been a molecule of interest for well over half a ...
Sakilam Satishkumar, Prasanna K. Vuram, Siva Subrahmanyam Relangi, Venkateshwarlu Gurram, Hong Zhou, Robert J. Kreitman, Michelle M. Martínez Montemayor, Lijia Yang, Muralidharan Kaliyaperumal, Somesh Sharma, Narender Pottabathini, Mahesh K. Lakshman   +11 more
doaj   +1 more source

Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics

mBio, 2023
The purine-derived signaling molecules c-di-AMP and (p)ppGpp control mecA/PBP2a-mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise the possibility that purine availability can control antibiotic susceptibility ...
Aaron C. Nolan, Merve S. Zeden, Igor Kviatkovski, Christopher Campbell, Lucy Urwin, Rebecca M. Corrigan, Angelika Gründling, James P. O’Gara   +7 more
doaj   +1 more source