In-silico investigation reveals microbial metabolic biomarkers and their regulatory roles in hormone sensitive cancers [PDF]
Journal of Genetic Engineering and BiotechnologyCancer burden has become a global concern, specifically with hormone-sensitive cancers (HSC). Among the various factors influencing the progress and treatment of cancers, the human microbiota plays a vital role.
Suvitha Anbarasu +3 more
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Guanosine 5‘-diphosphate-3‘-diphosphate inhibition of adenylosuccinate synthetase.
Journal of Biological Chemistry, 1979 The mechanism of ppGpp inhibition of adenylosuccinate synthetase (EC 6.3.4.4) was examined. Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP. This is in contrast to an earlier report (Gallant, J., Irr, J., and Cashel, M. (1971) J. Biol. Chem.
Mark M. Stayton, Herbert J. Fromm
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In vitro degradation of guanosine 5'-diphosphate, 3'-diphosphate. [PDF]
Proceedings of the National Academy of Sciences, 1977 The degradation of guanosine 5'-diphosphate,3'-diphosphate (ppGpp) by the "crude" ribosomal fraction of Escherichia coli CP78 (rel+, spoT+) was demonstrated and characterized. When the 3'-pyrophosphoryl group of ppGpp was hydrolyzed, the primary degradation product was 5'-GDP. Phosphorylation of ppGpp to guanosine 5'-triphosphate,3'-diphosphate (pppGpp)
J Sy
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Discovering and Targeting Dynamic Drugging Pockets of Oncogenic Proteins: The Role of Magnesium in Conformational Changes of the G12D Mutated Kirsten Rat Sarcoma-Guanosine Diphosphate Complex. [PDF]
Int J Mol Sci, 2022 Hu Z, Marti J.
europepmc +3 more sources
Rate studies of polysaccharide biosynthesis from guanosine diphosphate α-
Biochemical Journal, 1971 With enzyme preparations from Phaseolus aureus seedlings, the initial rate of 14C-labelled polysaccharide formation from GDP-α-d-[14C]glucose is not increased by additions of GDP-α-d-mannose. However, final incorporation is increased by addition of GDP-α-d-mannose, since the total reaction-time is extended. In contrast, the initial rate of 14C-labelled
C. L. Villemez
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Activation of Escherichia coli phosphoenolpyruvate carboxylase by guanosine‐5′‐diphosphate‐3′‐diphosphate [PDF]
FEBS Letters, 1977 Bacteria such as Escherichia coli respond to amino acid starvation by reducing the rate of syntheses of RNA, lipids, nucleotides and glycolytic esters [1,2]. This phenomenon is termed ‘stringent response’. It has been pointed out that, concomitant with this cellular response, a sharp increase in the intracellular levels of guanosine$-diphosphate3 ...
Taguchi, Masaaki +2 more
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Alpha-synuclein amyloids catalyze the degradation of ATP and other nucleotides [PDF]
Scientific ReportsIntracellular accumulation of alpha-synuclein amyloids is a main pathological hallmark in a subgroup of human neurodegenerative diseases called synucleinopathies.
Claudio Castillo-Cáceres +2 more
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The role of C-4-substituted mannose analogues in protein glycosylation. Effect of the guanosine diphosphate esters of 4-deoxy-4-fluoro-
Biochemical Journal, 1987 William McDowell +3 more
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Guanosine 5′-diphosphate 3′-diphosphate (ppGpp); guanosine 5′-triphosphate 3′-diphosphate (pppGpp) [PDF]
Science-Business eXchange, 2014 openalex +2 more sources