Results 11 to 20 of about 474 (133)
Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases
Cells, 2021 Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan +4 more
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Journal of International Medical Research, 2021 ARHGEF9 encodes collybistin, a brain-specific guanosine diphosphate-guanosine-5′-triphosphate exchange factor that plays an important role in clustering of gephyrin and γ-aminobutyric acid type A receptors in the postsynaptic membrane.
Tong Qiu, Qian Dai, Qiu Wang
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Structures of NS5 Methyltransferase from Zika Virus
Cell Reports, 2016 The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM ...
Javier Coloma +4 more
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Structural Insights into the Regulation Mechanism of Small GTPases by GEFs
Molecules, 2019 Small GTPases are key regulators of cellular events, and their dysfunction causes many types of cancer. They serve as molecular switches by cycling between inactive guanosine diphosphate (GDP)-bound and active guanosine triphosphate (GTP)-bound states ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
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Frontiers in Cell and Developmental Biology, 2021 Tumor interstitial fluid (TIF) surrounds and perfuses tumors and collects ions, metabolites, proteins, and extracellular vesicles secreted by tumor and stromal cells. Specific metabolites, accumulated within the TIF, could induce metabolic alterations of
Eleonora Vecchio +24 more
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Micro, 2022 Nucleoside diphosphate kinase (NDPK) enzyme in the sarcolemma membrane is crucial for the synthesis of cyclic adenosine monophosphate (cAMP) to maintain the calcium ion balance.
Andrey Zaznaev, Isaac Macwan
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Gαs slow conformational transition upon GTP binding and a novel Gαs regulator
iScience, 2023 Summary: G proteins are major signaling partners for G protein-coupled receptors (GPCRs). Although stepwise structural changes during GPCR–G protein complex formation and guanosine diphosphate (GDP) release have been reported, no information is available
Donghoon Ahn +12 more
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Frontiers in Physiology, 2015 Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving. Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long duration dives; during a routine dive, adults can hold their breath for 25 min ...
Myrna eBarjau Perez-Milicua +3 more
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Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs
Cells, 2019 Breast cancer is the most common malignant tumors in females. Although the conventional treatment has demonstrated a certain effect, some limitations still exist.
Yu Zhang +5 more
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source