Results 21 to 30 of about 66,472 (220)

Gαs slow conformational transition upon GTP binding and a novel Gαs regulator

iScience, 2023
Summary: G proteins are major signaling partners for G protein-coupled receptors (GPCRs). Although stepwise structural changes during GPCR–G protein complex formation and guanosine diphosphate (GDP) release have been reported, no information is available
Donghoon Ahn, Davide Provasi, Nguyen Minh Duc, Jun Xu, Leslie Salas-Estrada, Aleksandar Spasic, Min Woo Yun, Juyeong Kang, Dongmin Gim, Jaecheol Lee, Yang Du, Marta Filizola, Ka Young Chung   +12 more
doaj   +1 more source

GUANOSINE DIPHOSPHATE MANNOSE

Journal of Biological Chemistry, 1954
Blanco y ...
Cabib, Enrico, Leloir, Luis Federico
openaire   +3 more sources

AMP-Activated Protein Kinase Activation by 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) Inhibits Palmitate-Induced Endothelial Cell Apoptosis Through Reactive Oxygen Species Suppression

Journal of Pharmacological Sciences, 2008
AMP-activated protein kinase (AMPK) activation has an antiapoptotic effect in endothelial cells, but the mechanisms involved remain unclear. Here, we investigated whether AMPK activation could inhibit palmitate-induced apoptosis through suppression of ...
Ji-Eun Kim, Yong-Woon Kim, In Kyu Lee, Jong-Yeon Kim, Young Jin Kang, So-Young Park   +5 more
doaj   +1 more source

NUCLEOSIDE-DIPHOSPHATASE OF CESTODE BOTHRIOCEPHALUS SCORPII (CESTODA: BOTHRIOCEPHALIDAE)

Российский паразитологический журнал, 2016
Objective of research: To study the activities and properties of nucleoside- diphosphatase (NDPase) in cestode Bothriocephalus scorpii.Materials and methods: Cestodes were homogenized with 10 vol. of extraction medium. NDPase was detected in mitochondria
E. A. Burenina
doaj   +1 more source

Evidence for the intense exchange of MazG in marine cyanophages by horizontal gene transfer [PDF]

, 2008
Background: S-PM2 is a phage capable of infecting strains of unicellular cyanobacteria belonging to the genus Synechococcus. S-PM2, like other myoviruses infecting marine cyanobacteria, encodes a number of bacterial-like genes. Amongst these genes is one
M. J. Bryan (7607582), Samantha J Bryan, E. M. Spence (7607585), Nigel J Burroughs, Bryan Michael J., Bryan, Samantha J., Martha R J Clokie, Burroughs Nigel J., Spence, Edward M., Bryan Samantha J., Clokie Martha R. J., N. H. Mann (7607588), Bryan, Michael J., Edward M Spence, Mann Nicholas H., Nicholas H Mann, Michael J Bryan, Clokie, Martha R. J., Spence Edward M., N. J. Burroughs (7607594), Burroughs, Nigel John, Mann, Nicholas H., S. J. Bryan (7607591), Martha R. J. Clokie (6901562)   +23 more
core   +2 more sources

The Ps and Qs of alarmone synthesis in Staphylococcus aureus.

PLoS ONE, 2019
During the stringent response, bacteria synthesize guanosine-3',5'-bis(diphosphate) (ppGpp) and guanosine-5'-triphosphate 3'-diphosphate (pppGpp), which act as secondary messengers to promote cellular survival and adaptation.
Ning Yang, Shujie Xie, Nga-Yeung Tang, Mei Yee Choi, Ying Wang, Rory M Watt   +5 more
doaj   +1 more source

Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS

Cell Reports, 2020
Summary: The small guanosine triphosphatase (GTPase) RAS serves as a molecular switch in signal transduction, and its mutation and aberrant activation are implicated in tumorigenesis.
Qingci Zhao, Ryu Fujimiya, Satoshi Kubo, Christopher B. Marshall, Mitsuhiko Ikura, Ichio Shimada, Noritaka Nishida   +6 more
doaj   +1 more source

Roles of Rap1 signaling in tumor cell migration and invasion

Cancer Biology & Medicine, 2017
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization.
Yi-Lei Zhang, Ruo-Chen Wang, Ken Cheng, Brian Z. Ring, Li Su   +4 more
doaj   +1 more source

Efficient Enzymatic Synthesis of Guanosine 5′-Diphosphate-Sugars and Derivatives [PDF]

, 2013
An N-acetylhexosamine 1-kinase from Bifidobacterium infantis (NahK_15697), a guanosine 5'-diphosphate (GDP)-mannose pyrophosphorylase from Pyrococcus furiosus (PFManC), and an Escherichia coli inorganic pyrophosphatase (EcPpA) were used efficiently for a
Zhao, Wei, Chen, Xi, Wan, Yue, Liu, Yonghui, Wang, Peng George, Li, Yanhong, Li, Lei   +6 more
core   +1 more source

Comparison of Anticancer Activities and Biosafety Between Salmonella enterica Serovar Typhimurium ΔppGpp and VNP20009 in a Murine Cancer Model

Frontiers in Microbiology, 2022
Salmonella Typhimurium defective in guanosine 5′-diphosphate-3′-diphosphate (ppGpp) synthesis (ΔppGpp) is an attenuated strain with good biosafety and excellent anticancer efficacy.
Xiaoqing Liu, Yanxia Guo, Yujie Sun, Yu Chen, Wenzhi Tan, Jung-Joon Min, Jin Hai Zheng   +6 more
doaj   +1 more source