Results 31 to 40 of about 30,526 (262)

Rho GTPases in Skeletal Muscle Development and Homeostasis

Cells, 2021
Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range
Sonia Rodríguez-Fdez, Xosé R. Bustelo
doaj   +1 more source

Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8. [PDF]

PLoS ONE, 2015
Actinobacillus pleuropneumoniae is a Gram-negative bacterium and the cause of porcine pleuropneumonia. When the bacterium encounters nutritional starvation, the relA-dependent (p)ppGpp-mediated stringent response is activated.
Gang Li, Fang Xie, Yanhe Zhang, Janine T Bossé, Paul R Langford, Chunlai Wang   +5 more
doaj   +1 more source

Rhamnose-Containing Compounds: Biosynthesis and Applications

Molecules, 2022
Rhamnose-associated molecules are attracting attention because they are present in bacteria but not mammals, making them potentially useful as antibacterial agents. Additionally, they are also valuable for tumor immunotherapy.
Siqiang Li, Fujia Chen, Yun Li, Lizhen Wang, Hongyan Li, Guofeng Gu, Enzhong Li   +6 more
doaj   +1 more source

In vitro degradation of guanosine 5'-diphosphate, 3'-diphosphate. [PDF]

Proceedings of the National Academy of Sciences, 1977
The degradation of guanosine 5'-diphosphate,3'-diphosphate (ppGpp) by the "crude" ribosomal fraction of Escherichia coli CP78 (rel+, spoT+) was demonstrated and characterized. When the 3'-pyrophosphoryl group of ppGpp was hydrolyzed, the primary degradation product was 5'-GDP. Phosphorylation of ppGpp to guanosine 5'-triphosphate,3'-diphosphate (pppGpp)
J Sy
openalex   +4 more sources

Characterization of the RelBbu Regulon in Borrelia burgdorferi Reveals Modulation of Glycerol Metabolism by (p)ppGpp. [PDF]

PLoS ONE, 2015
The bacterial stringent response is triggered by deficiencies of available nutrients and other environmental stresses. It is mediated by 5'-triphosphate-guanosine-3'-diphosphate and 5'-diphosphate-guanosine-3'-diphosphate (collectively (p)ppGpp) and ...
Julia V Bugrysheva, Christopher J Pappas, Darya A Terekhova, Radha Iyer, Henry P Godfrey, Ira Schwartz, Felipe C Cabello   +6 more
doaj   +1 more source

Role of ARHGEF3 as a GEF and mTORC2 Regulator

Frontiers in Cell and Developmental Biology, 2022
Guanine nucleotide exchange factors (GEFs) activate GTPases by stimulating the release of guanosine diphosphate to permit the binding of guanosine triphosphate.
Sana Abdul Khaliq, Sana Abdul Khaliq, Zobia Umair, Mee-Sup Yoon, Mee-Sup Yoon, Mee-Sup Yoon   +5 more
doaj   +1 more source

Gαs slow conformational transition upon GTP binding and a novel Gαs regulator

iScience, 2023
Summary: G proteins are major signaling partners for G protein-coupled receptors (GPCRs). Although stepwise structural changes during GPCR–G protein complex formation and guanosine diphosphate (GDP) release have been reported, no information is available
Donghoon Ahn, Davide Provasi, Nguyen Minh Duc, Jun Xu, Leslie Salas-Estrada, Aleksandar Spasic, Min Woo Yun, Juyeong Kang, Dongmin Gim, Jaecheol Lee, Yang Du, Marta Filizola, Ka Young Chung   +12 more
doaj   +1 more source

AMP-Activated Protein Kinase Activation by 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) Inhibits Palmitate-Induced Endothelial Cell Apoptosis Through Reactive Oxygen Species Suppression

Journal of Pharmacological Sciences, 2008
AMP-activated protein kinase (AMPK) activation has an antiapoptotic effect in endothelial cells, but the mechanisms involved remain unclear. Here, we investigated whether AMPK activation could inhibit palmitate-induced apoptosis through suppression of ...
Ji-Eun Kim, Yong-Woon Kim, In Kyu Lee, Jong-Yeon Kim, Young Jin Kang, So-Young Park   +5 more
doaj   +1 more source

Evidence for the intense exchange of MazG in marine cyanophages by horizontal gene transfer [PDF]

, 2008
Background: S-PM2 is a phage capable of infecting strains of unicellular cyanobacteria belonging to the genus Synechococcus. S-PM2, like other myoviruses infecting marine cyanobacteria, encodes a number of bacterial-like genes. Amongst these genes is one
M. J. Bryan (7607582), Samantha J Bryan, E. M. Spence (7607585), Nigel J Burroughs, Bryan Michael J., Bryan, Samantha J., Martha R J Clokie, Burroughs Nigel J., Spence, Edward M., Bryan Samantha J., Clokie Martha R. J., N. H. Mann (7607588), Bryan, Michael J., Edward M Spence, Mann Nicholas H., Nicholas H Mann, Michael J Bryan, Clokie, Martha R. J., Spence Edward M., N. J. Burroughs (7607594), Burroughs, Nigel John, Mann, Nicholas H., S. J. Bryan (7607591), Martha R. J. Clokie (6901562)   +23 more
core   +1 more source

NUCLEOSIDE-DIPHOSPHATASE OF CESTODE BOTHRIOCEPHALUS SCORPII (CESTODA: BOTHRIOCEPHALIDAE)

Российский паразитологический журнал, 2016
Objective of research: To study the activities and properties of nucleoside- diphosphatase (NDPase) in cestode Bothriocephalus scorpii.Materials and methods: Cestodes were homogenized with 10 vol. of extraction medium. NDPase was detected in mitochondria
E. A. Burenina
doaj   +1 more source