Results 31 to 40 of about 29,370 (164)

A Long Overdue Targeted Treatment for KRAS Mutations in NSCLC: Spotlight on Adagrasib

open access: yesLung Cancer: Targets and Therapy, 2022
Danielle Brazel,1 Zhaohui Arter,1 Misako Nagasaka1– 3 1Department of Medicine, University of California Irvine School of Medicine, Orange, CA, USA; 2Chao Family Comprehensive Cancer Center, Orange, CA, USA; 3St.
Brazel D, Arter Z, Nagasaka M
doaj  

Synthesis of Guanosine 5'-Diphosphate.

open access: yesChemical and Pharmaceutical Bulletin, 1959
Guanosine 5'-diphosphate was synthesized from guanosine 5'-monophosphate by the reaction of benzyl hydrogen phosphoramidate, followed by the catalytic hydrogenolysis, in a yield of 38%. The effect of water in the reaction media and correlation of the yield with the amount of reagents are discussed.
Ueda, Tohru, Ohtsuka, Eiko
openaire   +2 more sources

Hypoxanthine-guanine phosphoribosyltransferase and inosine 5’-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semiaquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa)

open access: yesFrontiers in Physiology, 2015
Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving. Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long duration dives; during a routine dive, adults can hold their breath for 25 min ...
Myrna eBarjau Perez-Milicua   +3 more
doaj   +1 more source

Role of Graphene Oxide in Inhibiting the Interactions between Nucleoside Diphosphate Kinases -B and -C

open access: yesMicro, 2022
Nucleoside diphosphate kinase (NDPK) enzyme in the sarcolemma membrane is crucial for the synthesis of cyclic adenosine monophosphate (cAMP) to maintain the calcium ion balance.
Andrey Zaznaev, Isaac Macwan
doaj   +1 more source

Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs

open access: yesCells, 2019
Breast cancer is the most common malignant tumors in females. Although the conventional treatment has demonstrated a certain effect, some limitations still exist.
Yu Zhang   +5 more
doaj   +1 more source

Purification, crystallization and preliminary X-ray crystallographic analysis of human ppGpp hydrolase, Mesh1

open access: yesJournal of Analytical Science and Technology, 2010
Bacterial SpoT is a Mn2+-dependent pyrophosphohydrolase to hydrolyze guanosine 3’-diphosphate-5’-diphosphate to guanosine diphosphate and pyrophosphate.
Dawei Sun, Hye-Yeon Kim, Young Ho Jeon
doaj  

Evolution of the bacterial nucleosidase PpnN and its relation to the stringent response

open access: yesMicrobial Cell, 2019
In our recent publication (Zhang et al., 2019), we demonstrate an interesting mode of regulation of purine metabolism unique to Proteobacteria. In this microreview, we would like to reflect on the ideas put forward, with special focus on protein domain ...
René Lysdal Bærentsen   +2 more
doaj   +1 more source

Regulation of Bacteriophage λ Development by Guanosine 5′-Diphosphate-3′-diphosphate

open access: yesVirology, 1999
On infection of its host, Escherichia coli, bacteriophage lambda can follow one of two alternative developmental pathways: lytic or lysogenic. Here we demonstrate that the "lysis-versus-lysogenization" decision is influenced by guanosine tetraphosphate (ppGpp), a nucleotide that is synthesized in E. coli cells in response to amino acid or carbon source
Słomińska, Monika   +2 more
openaire   +2 more sources

The advantage of channeling nucleotides for very processive functions [version 2; referees: 3 approved]

open access: yesF1000Research, 2017
Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine ...
Diana Zala   +6 more
doaj   +1 more source

The advantage of channeling nucleotides for very processive functions [version 1; referees: 3 approved]

open access: yesF1000Research, 2017
Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine ...
Diana Zala   +6 more
doaj   +1 more source

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