Results 41 to 50 of about 66,472 (220)

In vitro degradation of guanosine 5'-diphosphate, 3'-diphosphate. [PDF]

Proceedings of the National Academy of Sciences, 1977
The degradation of guanosine 5'-diphosphate,3'-diphosphate (ppGpp) by the "crude" ribosomal fraction of Escherichia coli CP78 (rel+, spoT+) was demonstrated and characterized. When the 3'-pyrophosphoryl group of ppGpp was hydrolyzed, the primary degradation product was 5'-GDP. Phosphorylation of ppGpp to guanosine 5'-triphosphate,3'-diphosphate (pppGpp)
openaire   +2 more sources

Identification of the bacterial alarmone guanosine 5′-diphosphate 3′-diphosphate (ppGpp) in plants [PDF]

Proceedings of the National Academy of Sciences, 2004
Stringent control mediated by the bacterial alarmone guanosine 5′-diphosphate 3′-diphosphate (ppGpp) is a key regulatory process governing bacterial gene expression. By devising a system to measure ppGpp in plants, we have been able to identify ppGpp in the chloroplasts of plant cells. Levels of ppGpp increased markedly when plants
Kosaku, Takahashi, Koji, Kasai, Kozo, Ochi   +2 more
openaire   +2 more sources

Guanosine-Based Self-Assembly as an Enantioselective Catalyst Scaffold

, 2020
A self-assembled G-quadruplex formed by guanosine and borate as the chiral scaffold was used to catalyze the asymmetric Friedel–Crafts reaction in water.
Xiaolin Sun (53844), Renzhong Qiao (1447285), Chao Li (145513), Jiakun Bai (8350350), Haisheng Wang (1434631)   +4 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase [PDF]

, 2006
Brockmann-Gretza O, Kalinowski J. Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase. BMC Genomics.
Brockmann-Gretza Olaf, Kalinowski Jörn, Kalinowski, Jörn, Brockmann-Gretza, Olaf, Olaf Brockmann-Gretza, Jörn Kalinowski   +5 more
core   +1 more source

Guanosine 5'-diphosphate 3'-diphosphate (ppGpp) as a negative modulator of polynucleotide phosphorylase activity in a 'rare' actinomycete.

, 2010
With the beginning of the idiophase the highly phosphorylated guanylic nucleotides guanosine 5'-diphosphate 3'-diphosphate (ppGpp) and guanosine 5'-triphosphate 3'-diphosphate (pppGpp), collectively referred to as (p)ppGpp, activate stress survival ...
di Summa R, Tredici SM, SICULELLA, Luisa, Alduina R, DAMIANO, FABRIZIO, ALIFANO, Pietro, GNONI, Gabriele Vincenzo   +6 more
core   +2 more sources

Liquid chromatographic method for extracellular Guanosine 5′-triphosphate and tetrahydrobiopterin pathway products analysis from cadaveric samples and human biofluids

Journal of Chromatography Open
To gain a deep insight and to obtain a superior understanding about guanosine-based pathway, this paper reports an innovative approach to study this critical subject.
M. Perrucci, C. Santangelo, D. Bondi, T. Pietrangelo, F. Savini, A.M. Catena, M. Bonelli, M. Locatelli, C. D'Ovidio   +8 more
doaj   +1 more source

A Long Overdue Targeted Treatment for KRAS Mutations in NSCLC: Spotlight on Adagrasib

Lung Cancer: Targets and Therapy, 2022
Danielle Brazel,1 Zhaohui Arter,1 Misako Nagasaka1– 3 1Department of Medicine, University of California Irvine School of Medicine, Orange, CA, USA; 2Chao Family Comprehensive Cancer Center, Orange, CA, USA; 3St.
Brazel D, Arter Z, Nagasaka M
doaj  

Metabolites Profiling of Melanoma Interstitial Fluids Reveals Uridine Diphosphate as Potent Immune Modulator Capable of Limiting Tumor Growth

Frontiers in Cell and Developmental Biology, 2021
Tumor interstitial fluid (TIF) surrounds and perfuses tumors and collects ions, metabolites, proteins, and extracellular vesicles secreted by tumor and stromal cells. Specific metabolites, accumulated within the TIF, could induce metabolic alterations of
Eleonora Vecchio, Carmen Caiazza, Selena Mimmi, Angelica Avagliano, Enrico Iaccino, Teresa Brusco, Nancy Nisticò, Domenico Maisano, Annamaria Aloisio, Ileana Quinto, Maurizio Renna, Giuseppina Divisato, Simona Romano, Martina Tufano, Massimo D’Agostino, Elena Vigliar, Antonino Iaccarino, Chiara Mignogna, Francesco Andreozzi, Gaia Chiara Mannino, Rosangela Spiga, Mariano Stornaiuolo, Alessandro Arcucci, Massimo Mallardo, Giuseppe Fiume   +24 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source