Results 41 to 50 of about 30,288 (231)

The role of free nucleotides in heart failure

Кардиоваскулярная терапия и профилактика
Aim. To assess the potential of studying the plasma level of free nucleotides as additional biomarkers of heart failure (HF) taking into account the clinical and paraclinical data of the patient, and to analyze its change during therapy.Material and ...
E. V. Kolesnikova, O. V. Myachina, A. N. Pashkov, A. A. Pashkova   +3 more
doaj   +1 more source

Inhibition of development of Shiga toxin-converting bacteriophages by either treatment with citrate or amino acid starvation [PDF]

, 2012
Objectives: Shiga toxin–producing Escherichia coli (STEC) are pathogenic strains, whose virulence depends on induction of Shiga toxin–converting prophages and their subsequent lytic development.
Bożena Nejman-Faleńczyk, Grzegorz Węgrzyn, Maciąg, Monika, Alicja Wegrzyn, Węgrzyn, Alicja, Węgrzyn, Grzegorz, Golec, Piotr, Nejman-Faleńczyk, Bożena, Monika Maciąg, Piotr Golec   +9 more
core   +1 more source

Structures of NS5 Methyltransferase from Zika Virus

Cell Reports, 2016
The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM ...
Javier Coloma, Rinku Jain, Kanagalaghatta R. Rajashankar, Adolfo García-Sastre, Aneel K. Aggarwal   +4 more
doaj   +1 more source

Structural Insights into the Regulation Mechanism of Small GTPases by GEFs

Molecules, 2019
Small GTPases are key regulators of cellular events, and their dysfunction causes many types of cancer. They serve as molecular switches by cycling between inactive guanosine diphosphate (GDP)-bound and active guanosine triphosphate (GTP)-bound states ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
doaj   +1 more source

In vitro degradation of guanosine 5'-diphosphate, 3'-diphosphate. [PDF]

Proceedings of the National Academy of Sciences, 1977
The degradation of guanosine 5'-diphosphate,3'-diphosphate (ppGpp) by the "crude" ribosomal fraction of Escherichia coli CP78 (rel+, spoT+) was demonstrated and characterized. When the 3'-pyrophosphoryl group of ppGpp was hydrolyzed, the primary degradation product was 5'-GDP. Phosphorylation of ppGpp to guanosine 5'-triphosphate,3'-diphosphate (pppGpp)
openaire   +2 more sources

Identification of the bacterial alarmone guanosine 5′-diphosphate 3′-diphosphate (ppGpp) in plants [PDF]

Proceedings of the National Academy of Sciences, 2004
Stringent control mediated by the bacterial alarmone guanosine 5′-diphosphate 3′-diphosphate (ppGpp) is a key regulatory process governing bacterial gene expression. By devising a system to measure ppGpp in plants, we have been able to identify ppGpp in the chloroplasts of plant cells. Levels of ppGpp increased markedly when plants
Kosaku, Takahashi, Koji, Kasai, Kozo, Ochi   +2 more
openaire   +2 more sources

Efficient Enzymatic Synthesis of Guanosine 5′-Diphosphate-Sugars and Derivatives

, 2016
An N-acetylhexosamine 1-kinase from Bifidobacterium infantis (NahK_15697), a guanosine 5′-diphosphate (GDP)-mannose pyrophosphorylase from Pyrococcus furiosus (PFManC), and an Escherichia coli inorganic pyrophosphatase (EcPpA) were used efficiently for a
Lei Li (29537), Yanhong Li (661033), Peng George Wang (256049), Yue Wan (301736), Wei Zhao (14321), Yonghui Liu (336319), Xi Chen (35903)   +6 more
core   +1 more source

Metabolites Profiling of Melanoma Interstitial Fluids Reveals Uridine Diphosphate as Potent Immune Modulator Capable of Limiting Tumor Growth

Frontiers in Cell and Developmental Biology, 2021
Tumor interstitial fluid (TIF) surrounds and perfuses tumors and collects ions, metabolites, proteins, and extracellular vesicles secreted by tumor and stromal cells. Specific metabolites, accumulated within the TIF, could induce metabolic alterations of
Eleonora Vecchio, Carmen Caiazza, Selena Mimmi, Angelica Avagliano, Enrico Iaccino, Teresa Brusco, Nancy Nisticò, Domenico Maisano, Annamaria Aloisio, Ileana Quinto, Maurizio Renna, Giuseppina Divisato, Simona Romano, Martina Tufano, Massimo D’Agostino, Elena Vigliar, Antonino Iaccarino, Chiara Mignogna, Francesco Andreozzi, Gaia Chiara Mannino, Rosangela Spiga, Mariano Stornaiuolo, Alessandro Arcucci, Massimo Mallardo, Giuseppe Fiume   +24 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source