Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis. [PDF]
PLoS ONE, 2015 Growing evidences indicate that Ly-GDI, an inhibitory protein of Rho GTPases, plays an essential role in regulating actin cytoskeletal alteration which is indispensible for the process such as phagocytosis.
Chunguang Yan +5 more
doaj +2 more sources
In-silico investigation reveals microbial metabolic biomarkers and their regulatory roles in hormone sensitive cancers [PDF]
Journal of Genetic Engineering and BiotechnologyCancer burden has become a global concern, specifically with hormone-sensitive cancers (HSC). Among the various factors influencing the progress and treatment of cancers, the human microbiota plays a vital role.
Suvitha Anbarasu +3 more
doaj +2 more sources
FORMATION OF GUANOSINE DIPHOSPHATE FUCOSE FROM GUANOSINE DIPHOSPHATE MANNOSE
Journal of the American Chemical Society, 1958 V Ginsburg
exaly +3 more sources
Alpha-synuclein amyloids catalyze the degradation of ATP and other nucleotides [PDF]
Scientific ReportsIntracellular accumulation of alpha-synuclein amyloids is a main pathological hallmark in a subgroup of human neurodegenerative diseases called synucleinopathies.
Claudio Castillo-Cáceres +2 more
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Rho GTPases in Skeletal Muscle Development and Homeostasis
Cells, 2021 Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle between an inactive guanosine diphosphate (GDP)-bound and an active guanosine triphosphate (GTP)-bound state during signal transduction. As such, they regulate a wide range
Sonia Rodríguez-Fdez, Xosé R. Bustelo
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Streptomyces clavuligerus was grown in nutrient-limited defined media in laboratory scale fermenters using continuous and batch culture methods. Cephamycin C was produced in all fermentations.
Jones, Christine
core +6 more sources
Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8. [PDF]
PLoS ONE, 2015 Actinobacillus pleuropneumoniae is a Gram-negative bacterium and the cause of porcine pleuropneumonia. When the bacterium encounters nutritional starvation, the relA-dependent (p)ppGpp-mediated stringent response is activated.
Gang Li +5 more
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Rhamnose-Containing Compounds: Biosynthesis and Applications
Molecules, 2022 Rhamnose-associated molecules are attracting attention because they are present in bacteria but not mammals, making them potentially useful as antibacterial agents. Additionally, they are also valuable for tumor immunotherapy.
Siqiang Li +6 more
doaj +1 more source
Characterization of the RelBbu Regulon in Borrelia burgdorferi Reveals Modulation of Glycerol Metabolism by (p)ppGpp. [PDF]
PLoS ONE, 2015 The bacterial stringent response is triggered by deficiencies of available nutrients and other environmental stresses. It is mediated by 5'-triphosphate-guanosine-3'-diphosphate and 5'-diphosphate-guanosine-3'-diphosphate (collectively (p)ppGpp) and ...
Julia V Bugrysheva +6 more
doaj +1 more source
Role of ARHGEF3 as a GEF and mTORC2 Regulator
Frontiers in Cell and Developmental Biology, 2022 Guanine nucleotide exchange factors (GEFs) activate GTPases by stimulating the release of guanosine diphosphate to permit the binding of guanosine triphosphate.
Sana Abdul Khaliq +5 more
doaj +1 more source