Results 71 to 80 of about 474 (133)

Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica

Beilstein Journal of Organic Chemistry, 2012
A series of methoxy and deoxy derivatives of mannopyranose-1-phosphate (Manp-1P) were chemically synthesized, and their ability to be converted into the corresponding guanosine diphosphate mannopyranose (GDP-Manp) analogues by a pyrophosphorylase (GDP ...
Lu Zou, Ruixiang Blake Zheng, Todd L. Lowary   +2 more
doaj   +1 more source

Polymeric Giant Unilamellar Vesicles Support Longevity of Native Nuclei in Protocells

Small Science, Volume 5, Issue 6, June 2025.
Native nuclei are isolated and incorporated into polymeric giant unilamellar vesicles (pGUVs) using microfluidics. Nucleated pGUVs retain nuclear integrity and function, providing a new platform to study the import process of peptide‐based multicompartment micelles via nuclear localization signals. This bottom‐up chimeric system lays the groundwork for
Lukas Heuberger, Arianna Balestri, Shabnam Tarvirdipour, Larisa E. Kapinos, Roderick Y. H. Lim, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +7 more
wiley   +1 more source

Depression of Guanosine Diphosphate-Mannose Pyrophosphorylase by Mutations in Two Different Regulator Genes Involved in Capsular Polysaccharide Synthesis in Escherichia coli K-12 [PDF]

, 1970
Michael M. Lieberman, Alvin Markovitz
openalex   +1 more source

Global identification of key genes for pollen germination in rice through high‐throughput screening and gene editing

Journal of Integrative Plant Biology, Volume 67, Issue 6, Page 1665-1684, June 2025.
A systematic examination of 107 T‐DNA insertional lines targeting 105 genes preferentially expressed in late pollen development identified 42 lines exhibiting significant deviations from expected Mendelian segregation ratios, suggesting a potential involvement in pollen viability and germination.
Eui‐Jung Kim, Woo‐Jong Hong, Yu‐Jin Kim, Eun Young Kim, Sang Dae Yun, Sunok Moon, Su‐Kyoung Lee, Soon Ki Park, Ki‐Hong Jung   +8 more
wiley   +1 more source

Orchestrating Neural Development Through mRNA Translation Regulation

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review provides an overview of mRNA translation mechanisms that control prenatal brain development, including cortical lamination, progenitor differentiation, and axon guidance, and identifies significant knowledge gaps. Specifically, we focus on mRNA translation regulation through signaling cascades such as the mammalian/mechanistic target of ...
Brandon Rodrigue, Mathew Sajish, Natalina Salmaso, Argel Aguilar‐Valles   +3 more
wiley   +1 more source

Exploration of archaeal nucleotide sugar epimerases unveils a new and highly promiscuous GDP-Gal4E subgroup

Current Research in Biotechnology, 2022
UDP-galactose 4-epimerase (Gal4E, EC 5.1.3.2) catalyses the interconversion of UDP-galactose and UDP-glucose by inverting the configuration of the 4′-hydroxyl group of the sugar moiety. This enzyme is one of the mechanistically best-characterized members
Carlos Alvarez Quispe, Matthieu Da Costa, Koen Beerens, Tom Desmet   +3 more
doaj  

Impact of Mutational Status on Intracellular Effects of Cell‐Permeable CaaX Peptides in Pancreatic Cancer Cells

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
This work deals with intracellular effects of cell‐permeable CaaX‐peptides, designed to influence prenylated proteins like KRas. The results show that after CaaX‐1 treatment, not only KRas expression and signaling are specifically altered in mutated pancreatic cancer cells, but also plasma membrane localization of KRas is affected.
Merlin Klußmann, Martin Matijass, Ines Neundorf   +2 more
wiley   +1 more source

The Guanosine 3′,5′‐Bis(diphosphate) (ppGpp) Cycle [PDF]

, 1979
Dietmar Richter, Susanne Fehr, Reiner Harder   +2 more
openalex   +1 more source

Formation of Uridine Diphosphate 2‐Deoxy‐d‐glucose and Guanosine Diphosphate 2‐Deoxy‐d‐glucose in vitro Using Animal Enzymes [PDF]

, 1976
Ralph Τ. Schwarz, Michael F.G. Schmidt
openalex   +1 more source

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity

mBio
Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of ...
Fukang She, Kuanqing Liu, Brent W. Anderson, Tippapha Pisithkul, Yanxiu Li, Danny K. Fung, Tyler McCue, William Mulhern, Daniel Amador-Noguez, Jue D. Wang   +9 more
doaj   +1 more source