Results 91 to 100 of about 46,501 (205)

Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Escherichia coli Modulates Proteolysis of LpxC

Frontiers in Microbiology, 2019
Lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria provide the first line of defense against antibiotics and other harmful compounds. LPS biosynthesis critically depends on LpxC catalyzing the first committed enzyme in this process.
Nikolas Thomanek, Jan Arends, Claudia Lindemann, Katalin Barkovits, Helmut E. Meyer, Helmut E. Meyer, Katrin Marcus, Franz Narberhaus   +7 more
doaj   +1 more source

Distinguishing Crohn’s Disease From Non–Crohn’s Ileitis: A Gut Microbiome–Based Approach

Advanced Gut &Microbiome Research, Volume 2025, Issue 1, 2025.
Background: The differential diagnosis between symptomatic non–Crohn’s ileitis (NCI) and Crohn’s disease (CD) has been a long‐standing dilemma with similar clinical, endoscopic, and histopathology findings. We aimed to conduct a pilot study to compare the fecal microbiome between NCI and CD.
Nalini Raghunathan, Varun Joshi, Dhanush Mekala, Rajendra Patel, Shubhankar Godbole, Rupjyoti Talukdar, Duvvur Nageshwar Reddy, Rupa Banerjee, Jian Wu   +8 more
wiley   +1 more source

Control of rRNA synthesis in Escherichia coli at increased rrn gene dosage. Role of guanosine tetraphosphate and ribosome feedback.

Journal of Biological Chemistry, 1991
The effects of extra, plasmid-borne rRNA genes on the synthesis rate of rRNA in Escherichia coli were examined by measuring the fraction of total RNA synthesis that is rRNA and tRNA (rs/rt), the cytoplasmic concentration of guanosine tetraphosphate ...
E. Baracchini, H. Bremer
semanticscholar   +1 more source

The contribution of mRNA targeting to spatial protein localization in bacteria

The FEBS Journal, Volume 291, Issue 21, Page 4639-4659, November 2024.
mRNA‐based targeting serves as a back‐up strategy for the canonical signal sequence‐based protein targeting in bacteria. While signal sequence‐based targeting depends on dedicated protein‐targeting factors, mRNAs encoding inner membrane proteins can bind directly to protein translocases.
Wenkang Shang, Elisabeth Lichtenberg, Andreea Mihaela Mlesnita, Annegret Wilde, Hans‐Georg Koch   +4 more
wiley   +1 more source

Antimicrobial efficacy of DJK‐5 peptide in combination with EDTA against biofilms in dentinal tubules: Primary irrigation, recovery and re‐irrigation

International Endodontic Journal, Volume 57, Issue 9, Page 1343-1359, September 2024.
Abstract Aim To investigate the dynamic recovery of biofilms within dentinal tubules after primary irrigation with different protocols, and to evaluate the efficacy of various re‐irrigation protocols on recovered biofilm, considering factors such as smear layer, nutrient conditions, and primary irrigants.
Mohamed Amhmed, He Liu, Lari Häkkinen, Markus Haapasalo, Ya Shen   +4 more
wiley   +1 more source

Versatile enzymatic system for the production of guanosine polyphosphates [PDF]

, 2010
During periods of environmental stress, bacteria synthesize guanosine tetraphosphate (ppGpp, magic spot I) and guanosine pentaphosphate (pppGpp, magic spot II) in a process known as the stringent response.
Wang, Y, Watt, RM, Choi, MMY
core  

Broadening the Substrate Scope of a Polyphosphate Kinase for Canonical and Non‐Canonical Nucleotides

ChemCatChem, Volume 16, Issue 15, August 12, 2024.
In this study, we investigate the substrate spectrum of a polyphosphate kinase for the conversion of non‐canonical nucleotides. Guided by the structure, we created an enzyme variant with enhanced substrate scope for a broad variety of canonical and non‐canonical purine nucleotides. Abstract Polyphosphate kinases (PPKs) are valuable biocatalysts for ATP
Toni Querengässer, Jessica Wenzlaff, Christoph Loderer   +2 more
wiley   +1 more source

ESCHERICHIA COLI GROWTH MODELS WITH GUANOSINE TETRAPHOSPHATE CONTROLLED STRINGENT RESPONSE

, 2013
Includes bibliographical references (pages 40-45).Escherichia coli growth is strongly regulated by environmental conditions, evoking a stringent response when nutrient supplies are low and exponential growth when nutrient levels are high. This paper sets
Wang, Sara
core  

Phages produce persisters

Microbial Biotechnology, Volume 17, Issue 8, August 2024.
Bacterial infections are predicted to be the main cause of death by 2050, and persister cells often form during periods of lethal stress. Here, we show phage infections generate persister cells, and these persisters may undermine phage therapy. Abstract Arguably, the greatest threat to bacteria is phages.
Laura Fernández‐García, Joy Kirigo, Daniel Huelgas‐Méndez, Michael J. Benedik, María Tomás, Rodolfo García‐Contreras, Thomas K. Wood   +6 more
wiley   +1 more source

Adaptation of a fluoroquinolone-sensitive Shigella sonnei to norfloxacin exposure

Royal Society Open Science
Shigella causes shigellosis that requires antibiotic treatment in severe cases. Sublethal antibiotic concentrations can promote resistance, but their effect on antibiotic-sensitive bacteria before resistance development is unclear.
Bao Chi Wong, Soffi Kei Kei Law, Muhammad Zarul Hanifah Md Zoqratt, Qasim Ayub, Hock Siew Tan   +4 more
doaj   +1 more source