Results 71 to 80 of about 46,501 (205)

A Single‐Nucleotide Substitution Generates a de Novo Promoter That Activates a Latent Metabolic Bypass in Escherichia coli

Molecular Microbiology, EarlyView.
A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo, Qi Zou, Jilong Qin, Makrina Totsika, Yaoqin Hong, John E. Cronan   +5 more
wiley   +1 more source

Studies on the structure and function of protein kinase G, a virulence factor of "Mycobacterium tuberculosis" [PDF]

, 2008
The genome of M. tuberculosis comprises eleven serine/threonine protein kinases which carry out various functions, e.g. in cell division, metabolism and pathogenicity.
Scherr, Nicole
core   +1 more source

Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments

Water and Environment Journal, Volume 40, Issue 2, Page 183-202, May 2026.
Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze, Musa Marimani, Katlego Mamabolo, Mrudula Patel   +3 more
wiley   +1 more source

The primary transcriptome of Salmonella enterica Serovar Typhimurium and its dependence on ppGpp during late stationary phase. [PDF]

PLoS ONE, 2014
We have used differential RNA-seq (dRNA-seq) to characterise the transcriptomic architecture of S. Typhimurium SL1344, and its dependence on the bacterial alarmone, guanosine tetraphosphate (ppGpp) during late stationary phase, (LSP).
Vinoy K Ramachandran, Neil Shearer, Arthur Thompson   +2 more
doaj   +1 more source

The stringent response and physiological roles of (pp)pGpp in bacteria [PDF]

, 2021
The stringent response is a stress signalling system mediated by the alarmones guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient deprivation.
Irving, S.E., Choudhury, N.R., Naznin R. Choudhury, Sophie E. Irving, Rebecca M. Corrigan, Corrigan, R.M.   +5 more
core   +1 more source

Induction of the Stringent Response Underlies the Antimicrobial Action of Aliphatic Isothiocyanates

Frontiers in Microbiology, 2021
Bacterial resistance to known antibiotics comprises a serious threat to public health. Propagation of multidrug-resistant pathogenic strains is a reason for undertaking a search for new therapeutic strategies, based on newly developed chemical compounds ...
Dariusz Nowicki, Klaudyna Krause, Patrycja Szamborska, Adrianna Żukowska, Grzegorz M. Cech, Agnieszka Szalewska-Pałasz   +5 more
doaj   +1 more source

Nanomedicine Strategies Against Biofilm‐Associated Infections: Advances, Challenges, and Translational Barriers

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Explore the key challenges and limitations in nanomedicine for biofilm treatment, from drug loading efficiency to antimicrobial resistance. ABSTRACT Antimicrobial resistance continues to rise globally, with biofilm‐associated infections intensifying the clinical burden through persistent tolerance to antibiotics and evasion of immune responses ...
Husni Farah, Munthar Kadhim‐Abosaoda, Hayjaa Mohaisen‐Mousa, S. Renuka Jyothi, Priya Priyadarshini‐Nayak, J. Bethanney Janney, Gurjant Singh, Ashish Singh‐Chauhan, Manoj Kumar‐Mishra   +8 more
wiley   +1 more source

Differential inhibition of cellular and viral pp60src kinase by P1,P4-di(adenosine-5')tetraphosphate.

, 1983
We contrasted the protein kinase activities of pp60v-src, the transforming protein of Rous sarcoma virus, and its normal cellular homolog pp60c-src with respect to inhibition by P1,P4-di(adenosine-5')tetraphosphate by using the immune complex protein ...
Drum, C C, Maness, P F, Sorge, L K, Levy, B T   +3 more
core   +1 more source

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

ChemistryEurope, Volume 3, Issue 6, November 11, 2025.
Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling, Wiebke Teich, Bayram Terzi, Helena Schepers, Sabine Hüwel, Andrea Rentmeister   +5 more
wiley   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source