Results 51 to 60 of about 4,703 (162)
EBioMedicine, 2016 Cutaneous abscess infections are difficult to treat with current therapies and alternatives to conventional antibiotics are needed. Understanding the regulatory mechanisms that govern abscess pathology should reveal therapeutic interventions for these ...
Sarah C. Mansour +7 more
doaj +1 more source
relA enhances the adherence of enteropathogenic Escherichia coli. [PDF]
PLoS ONE, 2014 Enteropathogenic Escherichia coli (EPEC) is a known causative agent of diarrhea in children. In the process of colonization of the small intestine, EPEC synthesizes two types of adhesins, the bundle-forming pilus (BFP) and intimin.
Beny Spira +2 more
doaj +1 more source
Life, 2014 Second messengers are intracellular substances regulated by specific external stimuli globally known as first messengers. Cells rely on second messengers to generate rapid responses to environmental changes and the importance of their roles is becoming ...
Marco Agostoni, Beronda L. Montgomery
doaj +1 more source
Microbiology Spectrum, 2022 BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence.
Feiyang Zhang +8 more
doaj +1 more source
A Physiological Basis for Nonheritable Antibiotic Resistance
mBio, 2020 Antibiotics constitute one of the cornerstones of modern medicine. However, individuals may succumb to a bacterial infection if a pathogen survives exposure to antibiotics.
Mauricio H. Pontes, Eduardo A. Groisman
doaj +1 more source
eLife, 2018 Two classes of riboswitches related to the ykkC guanidine-I riboswitch bind phosphoribosyl pyrophosphate (PRPP) and guanosine tetraphosphate (ppGpp). Here we report the co-crystal structure of the PRPP aptamer and its ligand. We also report the structure
Andrew John Knappenberger +2 more
doaj +1 more source
Molecular Plant-Microbe Interactions, 2023 Broad-spectrum biocontrol by Pseudomonas protegens CHA0 and other fluorescent pseudomonads is achieved through the generation of various secondary metabolites with antibiotic activities against not only other microbes but, also, nematodes and insects ...
Kasumi Takeuchi +3 more
doaj +1 more source
PLoS Biology, 2023 Detoxification, scavenging, and repair systems embody the archetypical antioxidant defenses of prokaryotic and eukaryotic cells. Metabolic rewiring also aids with the adaptation of bacteria to oxidative stress.
Sashi Kant +6 more
doaj +1 more source
Structural and functional insights into the mode of action of a universally conserved Obg GTPase. [PDF]
PLoS Biology, 2014 Obg proteins are a family of P-loop GTPases, conserved from bacteria to human. The Obg protein in Escherichia coli (ObgE) has been implicated in many diverse cellular functions, with proposed molecular roles in two global processes, ribosome assembly and
Boya Feng +12 more
doaj +1 more source
Promoter domain mediates guanosine tetraphosphate activation of the histidine operon. [PDF]
Proceedings of the National Academy of Sciences, 1986 We have analyzed the effects of the "alarmone" guanosine 5'-diphosphate 3'-diphosphate (ppGpp) on regulation of the Salmonella typhimurium histidine operon in vitro. Expression of the wild-type promoter, measured in a DNA-dependent transcription-translation system, was strongly dependent on ppGpp; addition of ppGpp stimulated his expression 22-fold ...
D L, Riggs +3 more
openaire +2 more sources