Results 51 to 60 of about 46,501 (205)

Determination of (p)ppGpp Levels During Stringent Response in Streptomyces coelicolor by Thin Layer Chromatography

Bio-Protocol, 2016
The stringent response in bacteria is a stress response that is mediated by the signaling molecules guanosine tetraphosphate and pentaphosphate [(p)ppGpp], alarmones that are also directly related to virulence. Therefore, determination of (p)ppGpp levels
Smitha Sivapragasam, Anne Grove
doaj   +1 more source

The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation. [PDF]

PLoS Pathogens, 2015
As the Lyme disease bacterium Borrelia burgdorferi traverses its enzootic cycle, alternating between a tick vector and a vertebrate host, the spirochete must adapt and persist in the tick midgut under prolonged nutrient stress between blood meals.
Dan Drecktrah, Meghan Lybecker, Niko Popitsch, Philipp Rescheneder, Laura S Hall, D Scott Samuels   +5 more
doaj   +1 more source

ppGpp accumulation reduces the expression of the global nitrogen homeostasis-modulating NtcA regulon by affecting 2-oxoglutarate levels

Communications Biology, 2023
The cyanobacterium Synechococcus elongatus PCC 7942 accumulates alarmone guanosine tetraphosphate (ppGpp) under stress conditions, such as darkness. A previous study observed that artificial ppGpp accumulation under photosynthetic conditions led to the ...
Ryota Hidese, Ryudo Ohbayashi, Yuichi Kato, Mami Matsuda, Kan Tanaka, Sousuke Imamura, Hiroki Ashida, Akihiko Kondo, Tomohisa Hasunuma   +8 more
doaj   +1 more source

An expanded whole-cell model of E. coli links cellular physiology with mechanisms of growth rate control

npj Systems Biology and Applications, 2022
Growth and environmental responses are essential for living organisms to survive and adapt to constantly changing environments. In order to simulate new conditions and capture dynamic responses to environmental shifts in a developing whole-cell model of ...
Travis A. Ahn-Horst, Luis Santiago Mille, Gwanggyu Sun, Jerry H. Morrison, Markus W. Covert   +4 more
doaj   +1 more source

Quantification of guanosine tetraphosphate and other nucleotides in plants and algae using stable isotope-labelled internal standards

bioRxiv, 2019
Guanosine tetraphosphate (G4P) and guanosine pentaphosphate (G5P) are signalling nucleotides found in bacteria and photosynthetic eukaryotes that are implicated in a wide-range of processes including stress acclimation, developmental transitions and ...
J. Bartoli, Sylvie Citerne, G. Mouille, E. Bouveret, B. Field   +4 more
semanticscholar   +1 more source

SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome

mBio, 2020
Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Liam F. Fitzsimmons, Lin Liu, Sashi Kant, Ju-Sim Kim, James K. Till, Jessica Jones-Carson, Steffen Porwollik, Michael McClelland, Andres Vazquez-Torres   +8 more
doaj   +1 more source

Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically

EBioMedicine, 2016
Cutaneous abscess infections are difficult to treat with current therapies and alternatives to conventional antibiotics are needed. Understanding the regulatory mechanisms that govern abscess pathology should reveal therapeutic interventions for these ...
Sarah C. Mansour, Daniel Pletzer, César de la Fuente-Núñez, Paul Kim, Gordon Y.C. Cheung, Hwang-Soo Joo, Michael Otto, Robert E.W. Hancock   +7 more
doaj   +1 more source

relA enhances the adherence of enteropathogenic Escherichia coli. [PDF]

PLoS ONE, 2014
Enteropathogenic Escherichia coli (EPEC) is a known causative agent of diarrhea in children. In the process of colonization of the small intestine, EPEC synthesizes two types of adhesins, the bundle-forming pilus (BFP) and intimin.
Beny Spira, Gerson Moura Ferreira, Luiz Gustavo de Almeida   +2 more
doaj   +1 more source

Survival Strategies in the Aquatic and Terrestrial World: The Impact of Second Messengers on Cyanobacterial Processes

Life, 2014
Second messengers are intracellular substances regulated by specific external stimuli globally known as first messengers. Cells rely on second messengers to generate rapid responses to environmental changes and the importance of their roles is becoming ...
Marco Agostoni, Beronda L. Montgomery
doaj   +1 more source

Identification of the BolA Protein Reveals a Novel Virulence Factor in K. pneumoniae That Contributes to Survival in Host

Microbiology Spectrum, 2022
BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence.
Feiyang Zhang, Xiangjin Yan, Jiawei Bai, Li Xiang, Manlin Ding, Qin Li, Biying Zhang, Qinghua Liang, Yingshun Zhou   +8 more
doaj   +1 more source