Results 41 to 50 of about 46,501 (205)

Mutating both relA and spoT of enteropathogenic Escherichia coli E2348/69 attenuates its virulence and induces interleukin 6 in vivo

Frontiers in Microbiology, 2023
Here, we report for the first time that disrupting both relA and spoT genes in enteropathogenic Escherichia coli E2348/69 can attenuate its virulence and significantly induce interleukin 6 (IL-6) in vivo.
Jun Bong Lee, Se Kye Kim, Dalmuri Han, Jang Won Yoon   +3 more
doaj   +1 more source

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.

PLoS Pathogens, 2021
Bacteria inhabit diverse environmental niches and consequently must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p ...
N Y Elizabeth Chau, Shehryar Ahmad, John C Whitney, Brian K Coombes   +3 more
doaj   +1 more source

Identification of a RelA/SpoT Homolog and Its Possible Role in the Accumulation of Astaxanthin in Haematococcus pluvialis

Frontiers in Plant Science, 2022
A RelA/SpoT homolog, HpRSH, was identified in Haematococcus pluvialis. HpRSH was found to catalyze Mg2+-dependent guanosine tetraphosphate (ppGpp) synthesis and Mn2+-dependent ppGpp hydrolysis, respectively.
Hui Jin, Hui Jin, Yong Min Lao, Jin Zhou, Zhong Hua Cai   +4 more
doaj   +1 more source

Guanosine pentaphosphate and guanosine tetraphosphate accumulation and induction of Myxococcus xanthus fruiting body development [PDF]

Journal of Bacteriology, 1980
Development of multicellular fruiting bodies of Myxococcus xanthus can be induced by limitation of any of a number of different classes of amino acids. Investigated were amino acids that wild-type strains of M. xanthus are unable to synthesize (isoleucine, leucine, and valine), can synthesize at a low rate (phenylalanine), or can normally synthesize at
C, Manoil, D, Kaiser
openaire   +2 more sources

The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities. [PDF]

PLoS ONE, 2012
Inorganic polyphosphate (poly-P), guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp) are ubiquitous in bacteria. These molecules play a variety of important physiological roles associated with stress resistance, persistence, and ...
Mei Y Choi, Ying Wang, Leo L Y Wong, Bing-Tai Lu, Wen-Yang Chen, Jian-Dong Huang, Julian A Tanner, Rory M Watt   +7 more
doaj   +1 more source

Recent functional insights into the magic role of (p)ppGpp in growth control

Computational and Structural Biotechnology Journal, 2023
Rapid growth and survival are two key traits that enable bacterial cells to thrive in their natural habitat. The guanosine tetraphosphate and pentaphosphate [(p)ppGpp], also known as “magic spot”, is a key second messenger inside bacterial cells as well ...
Haoyan Mu, Fei Han, Qian Wang, Yanling Wang, Xiongfeng Dai, Manlu Zhu   +5 more
doaj   +1 more source

Diguanosinetetraphosphatase from Rat Liver: Activity on Diadenosine Tetraphosphate and Inhibition by Adenosine Tetraphosphate

, 2022
The hydrolysis of diadenosine tetraphosphate, a compound previously described by others to occur in liver at concentrations of around 0.1 μM, is carried out by a specific enzyme.
Lobatón, Carmen D., Vallejo, Carmen G., Sillero, María A. G., Sillero, Antonio   +3 more
core   +1 more source

Forming and waking dormant cells: The ppGpp ribosome dimerization persister model

Biofilm, 2020
Procaryotes starve and face myriad stresses. The bulk population actively resists the stress, but a small population weathers the stress by entering a resting stage known as persistence.
Thomas K. Wood, Sooyeon Song
doaj   +1 more source

Regulation of ytfK by cAMP-CRP Contributes to SpoT-Dependent Accumulation of (p)ppGpp in Response to Carbon Starvation YtfK Responds to Glucose Exhaustion

Frontiers in Microbiology, 2021
Guanosine penta- or tetraphosphate (known as (p)ppGpp) serves as second messenger to respond to nutrient downshift and other environmental stresses, a phenomenon called stringent response.
Laura Meyer, Elsa Germain, Etienne Maisonneuve   +2 more
doaj   +1 more source

Evidence for the intense exchange of MazG in marine cyanophages by horizontal gene transfer [PDF]

, 2008
Background: S-PM2 is a phage capable of infecting strains of unicellular cyanobacteria belonging to the genus Synechococcus. S-PM2, like other myoviruses infecting marine cyanobacteria, encodes a number of bacterial-like genes. Amongst these genes is one
M. J. Bryan (7607582), Samantha J Bryan, E. M. Spence (7607585), Nigel J Burroughs, Bryan Michael J., Bryan, Samantha J., Martha R J Clokie, Burroughs Nigel J., Spence, Edward M., Bryan Samantha J., Clokie Martha R. J., N. H. Mann (7607588), Bryan, Michael J., Edward M Spence, Mann Nicholas H., Nicholas H Mann, Michael J Bryan, Clokie, Martha R. J., Spence Edward M., N. J. Burroughs (7607594), Burroughs, Nigel John, Mann, Nicholas H., S. J. Bryan (7607591), Martha R. J. Clokie (6901562)   +23 more
core   +1 more source