Results 21 to 30 of about 4,703 (162)

Loss of the plastidial signaling molecule, ppGpp, accumulation alters nuclear gene expression during nitrogen starvation [PDF]

Frontiers in Plant Science
Nitrogen (N) deficiency triggers major transcriptional reprogramming in plants. The chloroplast alarmone, guanosine tetraphosphate (ppGpp) synthesized and hydrolyzed by RelA-SpoT homologs (RSHs), has been proposed to regulate cellular metabolism.
Takanari Nemoto, Takanari Nemoto, Yuto Omata, Masataka Inazu, Kazuma Sakoda, Atsushi Sakurai, Sousuke Imamura, Shouta Nonoyama, Shouta Nonoyama, Shinji Masuda, Shinji Masuda   +10 more
doaj   +2 more sources

Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp [PDF]

mBio
Guanosine penta- and tetraphosphate [(p)ppGpp] and their adenosine analogs [(p)ppApp] are bacterial second messengers known as alarmones. Members of the RelA-SpoT homolog (RSH) family synthesize (p)ppGpp to mediate the stringent response during nutrient ...
Shehryar Ahmad, Andrea G. Guedez, Berti Manisa, Abdulmalik Adewale, Kara K. Tsang, Vanessa Schiefer, Nathan P. Bullen, Harmy Thakar, Youngchang Kim, Boyuan Wang, John C. Whitney   +10 more
doaj   +2 more sources

Guanosine tetraphosphate modulates salicylic acid signalling and the resistance of Arabidopsis thaliana to Turnip mosaic virus [PDF]

Molecular Plant Pathology, 2018
Sylvie Citerne, Hatem Fakhfakh, Gregory Mouillé   +2 more
exaly   +2 more sources

The search for guanosine tetraphosphate (ppGpp) and other unusual nucleotides in eucaryotes [PDF]

Microbiological Reviews, 1979
A G Atherly
exaly   +5 more sources

Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in Escherichia coli. [PDF]

Angew Chem Int Ed Engl
We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Popp C, Moser P, Schwoerbel A, Liu X, Freitag J, Sarmah P, Prucker I, Zscherp R, Wang X, Klahn P, Koch HG, Bange G, Jessen HJ.   +12 more
europepmc   +2 more sources

The 5' Cap Epitranscriptome and Beyond: Natural and Engineered 5' Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies. [PDF]

ChemMedChem
5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Dahm GC, Pieper M, Schepers H, Rentmeister A.   +3 more
europepmc   +2 more sources

Identification, characterization and expression analysis of wheat RSH family genes under abiotic stress

Frontiers in Plant Science, 2023
Guanosine pentaphosphate and guanosine tetraphosphate are collectively called (p)ppGpp (Guanosine tetraphosphate and pentaphosphate). (p)ppGpp content in plants is affected by conditions such as light, salt, pH, UV light, and environmental phytohormones.
Mengru Wang, Wei Hong, Youning Wang, Xiaowen Han, Wang Chen, Shuping Wang, Yingxin Zhang, Wenli Wang   +7 more
doaj   +1 more source

Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius

Frontiers in Microbiology, 2021
Research on nucleotide-based second messengers began in 1956 with the discovery of cyclic adenosine monophosphate (3′,5′-cAMP) by Earl Wilbur Sutherland and his co-workers.
Frank Braun, Alejandra Recalde, Heike Bähre, Roland Seifert, Sonja-Verena Albers   +4 more
doaj   +1 more source

Functional Characterization of Small Alarmone Synthetase and Small Alarmone Hydrolase Proteins from Treponema denticola

Microbiology Spectrum, 2023
The stringent response enables bacteria to survive nutrient starvation, antibiotic challenge, and other threats to cellular survival. Two alarmone (magic spot) second messengers, guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp ...
Miao Wang, Nga-Yeung Tang, Shujie Xie, Rory M. Watt   +3 more
doaj   +1 more source

The Elongation Factor Tu · Guanosine Tetraphosphate Complex [PDF]

European Journal of Biochemistry, 1981
The elongation factor Tu (EF‐Tu) isolated from Escherichia coli cells that have undergone the stringent response is predominantly complexed with guanosine 5′‐diphosphate 3′‐diphosphate. This complex can be separated by anion‐exchange chromatography from EF‐Tu · GDP‐ Unlike EF‐Tu complexed with guanosine 5′‐triphosphate 3′‐diphosphate, the complex with ...
A, Pingoud, W, Block
openaire   +2 more sources