An Interplay among FIS, H-NS, and Guanosine Tetraphosphate Modulates Transcription of the Escherichia coli cspA Gene under Physiological Growth Conditions [PDF]
Frontiers in Molecular Biosciences, 2016 CspA, the most characterized member of the csp gene family of Escherichia coli, is highly expressed not only in response to cold stress, but also during the early phase of growth at 37°C.
Maurizio Falconi +2 more
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A guanosine tetraphosphate (ppGpp) mediated brake on photosynthesis is required for acclimation to nitrogen limitation in Arabidopsis [PDF]
eLife, 2022 Guanosine pentaphosphate and tetraphosphate (together referred to as ppGpp) are hyperphosphorylated nucleotides found in bacteria and the chloroplasts of plants and algae.
Shanna Romand +12 more
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Guanosine Tetraphosphate Has a Similar Affinity for Each of Its Two Binding Sites on Escherichia coli RNA Polymerase [PDF]
Frontiers in Microbiology, 2020 During nutrient deprivation, the bacterial cell undergoes a stress response known as the stringent response. This response is characterized by induction of the nucleotide derivative guanosine tetraphosphate (ppGpp) that dramatically modulates the cell’s ...
Angela R. Myers +3 more
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Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth. [PDF]
Sci Rep, 2016 AbstractMost bacterial cells are stressed and as a result, some become tolerant to antibiotics by entering a dormant state known as persistence. The key intracellular metabolite that has been linked to this persister state is guanosine tetraphosphate (ppGpp), the alarmone that was first linked to nutrient stress.
Chowdhury N, Kwan BW, Wood TK.
europepmc +4 more sources
Accumulation of guanosine tetraphosphate and guanosine pentaphosphate in Myxococcus xanthus during starvation and myxospore formation [PDF]
Journal of Bacteriology, 1980 Cultures of Myxococcus xanthus develop multicellular fruiting bodies when starved for carbon and nitrogen sources on an agar surface. Under these conditions of severe starvation, cultures rapidly accumulated a compound identified as guanosine tetraphosphate by chromatographic migration of the compound and of its major acid and alkali breakdown products.
C, Manoil, D, Kaiser
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Conditions that trigger guanosine tetraphosphate accumulation in Caulobacter crescentus [PDF]
Journal of Bacteriology, 1981 Caulobacter crescentus accumulated guanosine tetraphosphate in response to nitrogen starvation but not in response to amino acid starvation. Nitrogen starvation also acted specifically to inhibit certain transitions in the C. crescentus life cycle, and guanosine tetraphosphate may act as an intracellular regulator of cell cycle events.
N Agabian, J Gallant
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Improved plant biomass production under low nitrogen conditions through conditional accumulation of the second messenger, guanosine tetraphosphate, in chloroplasts and mitochondria [PDF]
Frontiers in Plant ScienceTo enhance plant biomass production under low nitrogen conditions, we employed a method to artificially and temporarily accumulate the bacterial second messenger, guanosine tetraphosphate (ppGpp), to modify plastidial or mitochondrial metabolism ...
Mina Goto +5 more
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Bacterial alarmone (p)ppGpp mediates the pathogenicity of Clavibacter michiganensis via a dual mechanism that affects both enzyme production and the Tat secretion system [PDF]
mSystemsThe gram-positive bacterium Clavibacter michiganensis (Cm) causes bacterial canker of tomato. The infection process of Cm is of considerable interest, and the role of the alarmone guanosine tetraphosphate or pentaphosphate [(p)ppGpp], a global regulator,
Xiaoli Xu +7 more
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New perspectives on the molecular mechanisms of stress signalling by the nucleotide guanosine tetraphosphate (ppGpp), an emerging regulator of photosynthesis in plants and algae [PDF]
New Phytologist, 2023 Benjamin Field
exaly +2 more sources
Maintenance of cytoplasmic and membrane densities shapes cellular geometry in Escherichia coli [PDF]
Nature CommunicationsMicrobes precisely control their composition and geometry across diverse growth conditions, yet the mechanisms coordinating these processes remain unclear.
Griffin Chure +4 more
doaj +2 more sources