Results 31 to 40 of about 4,703 (162)
Frontiers in Microbiology, 2023 Here, we report for the first time that disrupting both relA and spoT genes in enteropathogenic Escherichia coli E2348/69 can attenuate its virulence and significantly induce interleukin 6 (IL-6) in vivo.
Jun Bong Lee +3 more
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PLoS Pathogens, 2021 Bacteria inhabit diverse environmental niches and consequently must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p ...
N Y Elizabeth Chau +3 more
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Variation in guanosine 5' ,3'-tetraphosphate levels in Chromatium [PDF]
Journal of Bacteriology, 1977 Chromatium produces guanosine 5' ,3'-tetraphosphate, but there appears to be no correlation between guanosine 5' ,3'-tetraphosphate concentration and the inability of the organism to grow in certain light-dark regimes.
G, Klaussmann, M, Miović
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Frontiers in Plant Science, 2022 A RelA/SpoT homolog, HpRSH, was identified in Haematococcus pluvialis. HpRSH was found to catalyze Mg2+-dependent guanosine tetraphosphate (ppGpp) synthesis and Mn2+-dependent ppGpp hydrolysis, respectively.
Hui Jin +4 more
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The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities. [PDF]
PLoS ONE, 2012 Inorganic polyphosphate (poly-P), guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp) are ubiquitous in bacteria. These molecules play a variety of important physiological roles associated with stress resistance, persistence, and ...
Mei Y Choi +7 more
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Guanosine pentaphosphate and guanosine tetraphosphate accumulation and induction of Myxococcus xanthus fruiting body development [PDF]
Journal of Bacteriology, 1980 Development of multicellular fruiting bodies of Myxococcus xanthus can be induced by limitation of any of a number of different classes of amino acids. Investigated were amino acids that wild-type strains of M. xanthus are unable to synthesize (isoleucine, leucine, and valine), can synthesize at a low rate (phenylalanine), or can normally synthesize at
C, Manoil, D, Kaiser
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Recent functional insights into the magic role of (p)ppGpp in growth control
Computational and Structural Biotechnology Journal, 2023 Rapid growth and survival are two key traits that enable bacterial cells to thrive in their natural habitat. The guanosine tetraphosphate and pentaphosphate [(p)ppGpp], also known as “magic spot”, is a key second messenger inside bacterial cells as well ...
Haoyan Mu +5 more
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Forming and waking dormant cells: The ppGpp ribosome dimerization persister model
Biofilm, 2020 Procaryotes starve and face myriad stresses. The bulk population actively resists the stress, but a small population weathers the stress by entering a resting stage known as persistence.
Thomas K. Wood, Sooyeon Song
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mBio, 2018 The adaptations that protect pathogenic microorganisms against the cytotoxicity of nitric oxide (NO) engendered in the immune response are incompletely understood.
Liam F. Fitzsimmons +4 more
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ppGpp Controls Global Gene Expression in Light and in Darkness in S. elongatus
Cell Reports, 2017 The bacterial and plant stringent response involves production of the signaling molecules guanosine tetraphosphate and guanosine pentaphosphate ((p)ppGpp), leading to global reorganization of gene expression.
Anna M. Puszynska, Erin K. O’Shea
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