Results 31 to 40 of about 46,501 (205)

Promoter domain mediates guanosine tetraphosphate activation of the histidine operon. [PDF]

Proceedings of the National Academy of Sciences, 1986
We have analyzed the effects of the "alarmone" guanosine 5'-diphosphate 3'-diphosphate (ppGpp) on regulation of the Salmonella typhimurium histidine operon in vitro. Expression of the wild-type promoter, measured in a DNA-dependent transcription-translation system, was strongly dependent on ppGpp; addition of ppGpp stimulated his expression 22-fold ...
D L, Riggs, R D, Mueller, H S, Kwan, S W, Artz   +3 more
openaire   +3 more sources

rpoB mutation in Escherichia coli alters control of ribosome synthesis by guanosine tetraphosphate [PDF]

Journal of Bacteriology, 1983
An isogenic pair of relA+ and relA strains of Escherichia coli B/r with a mutation in the RNA polymerase subunit gene rpoB (Rifr) was isolated in which the relationship between guanosine tetraphosphate (ppGpp) concentration and stable RNA (rRNA, tRNA) gene activity was altered.
R, Little, J, Ryals, H, Bremer
openaire   +3 more sources

High Intracellular Level of Guanosine Tetraphosphate in Mycobacterium smegmatis Changes the Morphology of the Bacterium [PDF]

Infection and Immunity, 2000
ABSTRACT Almost one-third of the world population today harbors the tubercle bacillus asymptomatically. It is postulated that the morphology and staining pattern of the long-term persistors are different from those of actively growing culture.
Ojha, Anil K, Mukherjee, Tapan K, Chatterji, Dipankar   +2 more
openaire   +4 more sources

Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp [PDF]

mBio
Guanosine penta- and tetraphosphate [(p)ppGpp] and their adenosine analogs [(p)ppApp] are bacterial second messengers known as alarmones. Members of the RelA-SpoT homolog (RSH) family synthesize (p)ppGpp to mediate the stringent response during nutrient ...
Shehryar Ahmad, Andrea G. Guedez, Berti Manisa, Abdulmalik Adewale, Kara K. Tsang, Vanessa Schiefer, Nathan P. Bullen, Harmy Thakar, Youngchang Kim, Boyuan Wang, John C. Whitney   +10 more
doaj   +2 more sources

Polyphosphate, cyclic AMP, guanosine tetraphosphate, and c-di-GMP reduce in vitro Lon activity. [PDF]

Bioengineered, 2014
Lon protease is conserved from bacteria to humans and regulates cellular processes by degrading different classes of proteins including antitoxins, transcriptional activators, unfolded proteins, and free ribosomal proteins.
Osbourne DO, Soo VW, Konieczny I, Wood TK.   +3 more
europepmc   +2 more sources

Regulation of Escherichia coli aspartate transcarbamylase synthesis by guanosine tetraphosphate and pyrimidine ribonucleoside triphosphates [PDF]

Journal of Bacteriology, 1983
The effects of guanosine tetraphosphate (ppGpp) and pyrimidine ribonucleoside triphosphates on Escherichia coli aspartate transcarbamylase (ATCase) synthesis were examined. To determine the effect of ppGpp, a stringent (relA+) and relaxed (relA) isogenic pair of E. coli K-12 strains was starved for isoleucine, and the residual rate of synthesis of this
C. Turnbough
openaire   +3 more sources

Identification, characterization and expression analysis of wheat RSH family genes under abiotic stress

Frontiers in Plant Science, 2023
Guanosine pentaphosphate and guanosine tetraphosphate are collectively called (p)ppGpp (Guanosine tetraphosphate and pentaphosphate). (p)ppGpp content in plants is affected by conditions such as light, salt, pH, UV light, and environmental phytohormones.
Mengru Wang, Wei Hong, Youning Wang, Xiaowen Han, Wang Chen, Shuping Wang, Yingxin Zhang, Wenli Wang   +7 more
doaj   +1 more source

Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius

Frontiers in Microbiology, 2021
Research on nucleotide-based second messengers began in 1956 with the discovery of cyclic adenosine monophosphate (3′,5′-cAMP) by Earl Wilbur Sutherland and his co-workers.
Frank Braun, Alejandra Recalde, Heike Bähre, Roland Seifert, Sonja-Verena Albers   +4 more
doaj   +1 more source

Functional Characterization of Small Alarmone Synthetase and Small Alarmone Hydrolase Proteins from Treponema denticola

Microbiology Spectrum, 2023
The stringent response enables bacteria to survive nutrient starvation, antibiotic challenge, and other threats to cellular survival. Two alarmone (magic spot) second messengers, guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp ...
Miao Wang, Nga-Yeung Tang, Shujie Xie, Rory M. Watt   +3 more
doaj   +1 more source

The Elongation Factor Tu · Guanosine Tetraphosphate Complex [PDF]

European Journal of Biochemistry, 1981
The elongation factor Tu (EF‐Tu) isolated from Escherichia coli cells that have undergone the stringent response is predominantly complexed with guanosine 5′‐diphosphate 3′‐diphosphate. This complex can be separated by anion‐exchange chromatography from EF‐Tu · GDP‐ Unlike EF‐Tu complexed with guanosine 5′‐triphosphate 3′‐diphosphate, the complex with ...
A, Pingoud, W, Block
openaire   +2 more sources