Results 61 to 70 of about 4,703 (162)
Molecular Microbiology, EarlyView.A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo +5 more
wiley +1 more source
Small molecule control of virulence gene expression in Francisella tularensis. [PDF]
PLoS Pathogens, 2009 In Francisella tularensis, the SspA protein family members MglA and SspA form a complex that associates with RNA polymerase (RNAP) to positively control the expression of virulence genes critical for the intramacrophage growth and survival of the ...
James C Charity +4 more
doaj +1 more source
Eine Universelle Nukleosid‐zu‐Nukleosid‐5′‐triphosphat‐Enzymkaskade angetrieben durch Polyphosphat
Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.Nukleosid‐5′‐Triphosphate (NTPs) sind wichtige Bausteine für Nukleinsäuren. Ihre chemische Synthese ist aufgrund der geringen Ausbeute der 5′‐Triphosphorylierungsreaktion nur wenig effizient. Wir stellen hier eine universelle, durch Polyphosphat angetriebene Zwei‐Enzym‐Kaskade vor, die eine direkte Phosphorylierung von Nukleosiden zu NTPs ermöglicht ...
Jonathan P. Suess +1 more
wiley +1 more source
A Universal Nucleoside‐to‐Nucleoside‐5′‐Triphosphate Enzyme Cascade Driven by Polyphosphate
Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.Nucleoside‐5′‐triphosphates (NTPs) are essential components for the generation of nucleic acids, yet their chemical synthesis is hindered by the low yield of nucleoside phosphorylation. Here, we present a universal, two‐enzyme nucleoside‐to‐NTP cascade that is driven by polyphosphate.
Jonathan P. Suess +1 more
wiley +1 more source
Identification of the Synthesis of Guanosine Tetraphosphate (MS I) as Insertion of a Pyrophosphoryl Group into the 3′-Position in Guanosine 5′-Diphosphate [PDF]
Proceedings of the National Academy of Sciences, 1973 The phosphate transfer system of Haseltine et al. , consisting of a ribosomal wash obtained from a stringent strain of Escherichia coli , washed ribosomes, GTP, and ATP, was used to prepare large quantities of guanosine tetra- and pentaphosphates, the ...
J, Sy, F, Lipmann
openaire +2 more sources
Proteomic Analysis of Lactococcus lactis FM03 Under Prolonged Alkaline Stress
Environmental Microbiology, Volume 28, Issue 7, July 2026.Overview of alkaline resistance mechanisms in Lactococcus lactis FM03. Sustained growth at pH 8 triggers extensive physiological remodelling, including activation of general stress response proteins, suppression of acid resistance, elevated amino acid production, altered cell wall biosynthesis, and doubling of the cell wall thickness.
Tamara A. L. Bendig +4 more
wiley +1 more source
Journal of Biological Chemistry, 1971 We have examined the intracellular levels of the guanosine tetraphosphate, guanosine 5'-diphosphate 2'- or 3'-diphosphate (ppGpp), in an isogenic pair of stringent and relaxed strains of Escherichia coli. As previously observed, relaxed strains do not accumulate ppGpp during amino acid deprivation, while stringent strains do.
R A, Lazzarini, M, Cashel, J, Gallant
openaire +2 more sources
rpoB mutation in Escherichia coli alters control of ribosome synthesis by guanosine tetraphosphate [PDF]
Journal of Bacteriology, 1983 An isogenic pair of relA+ and relA strains of Escherichia coli B/r with a mutation in the RNA polymerase subunit gene rpoB (Rifr) was isolated in which the relationship between guanosine tetraphosphate (ppGpp) concentration and stable RNA (rRNA, tRNA) gene activity was altered.
R, Little, J, Ryals, H, Bremer
openaire +2 more sources
Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments
Water and Environment Journal, Volume 40, Issue 2, Page 183-202, May 2026.Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze +3 more
wiley +1 more source
The primary transcriptome of Salmonella enterica Serovar Typhimurium and its dependence on ppGpp during late stationary phase. [PDF]
PLoS ONE, 2014 We have used differential RNA-seq (dRNA-seq) to characterise the transcriptomic architecture of S. Typhimurium SL1344, and its dependence on the bacterial alarmone, guanosine tetraphosphate (ppGpp) during late stationary phase, (LSP).
Vinoy K Ramachandran +2 more
doaj +1 more source