Results 61 to 70 of about 46,501 (205)
, 2013 Authors from the Instituto de Enzimologia del C.S.I.C.In the course of studies on the metabolic role of diguanosine tetraphosphate during development of Artemia salina, a guanosine monophosphate (GMP) reductase has been found and partially purified from ...
Renart, Marga F. +3 more
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A Physiological Basis for Nonheritable Antibiotic Resistance
mBio, 2020 Antibiotics constitute one of the cornerstones of modern medicine. However, individuals may succumb to a bacterial infection if a pathogen survives exposure to antibiotics.
Mauricio H. Pontes, Eduardo A. Groisman
doaj +1 more source
Transcription regulation of the Escherichia coli pcnB gene coding for poly(A) polymerase I: roles of ppGpp, DksA and sigma factors [PDF]
, 2010 Poly(A) polymerase I (PAP I), encoded by the pcnB gene, is a major enzyme responsible for RNA polyadenylation in Escherichia coli, a process involved in the global control of gene expression in this bacterium through inXuencing the rate of transcript ...
Grzegorz Węgrzyn +11 more
core +1 more source
eLife, 2018 Two classes of riboswitches related to the ykkC guanidine-I riboswitch bind phosphoribosyl pyrophosphate (PRPP) and guanosine tetraphosphate (ppGpp). Here we report the co-crystal structure of the PRPP aptamer and its ligand. We also report the structure
Andrew John Knappenberger +2 more
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PLoS Biology, 2023 Detoxification, scavenging, and repair systems embody the archetypical antioxidant defenses of prokaryotic and eukaryotic cells. Metabolic rewiring also aids with the adaptation of bacteria to oxidative stress.
Sashi Kant +6 more
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Molecular Plant-Microbe Interactions, 2023 Broad-spectrum biocontrol by Pseudomonas protegens CHA0 and other fluorescent pseudomonads is achieved through the generation of various secondary metabolites with antibiotic activities against not only other microbes but, also, nematodes and insects ...
Kasumi Takeuchi +3 more
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Structural and functional insights into the mode of action of a universally conserved Obg GTPase. [PDF]
PLoS Biology, 2014 Obg proteins are a family of P-loop GTPases, conserved from bacteria to human. The Obg protein in Escherichia coli (ObgE) has been implicated in many diverse cellular functions, with proposed molecular roles in two global processes, ribosome assembly and
Boya Feng +12 more
doaj +1 more source
Eine Universelle Nukleosid‐zu‐Nukleosid‐5′‐triphosphat‐Enzymkaskade angetrieben durch Polyphosphat
Angewandte Chemie, EarlyView.Nukleosid‐5′‐Triphosphate (NTPs) sind wichtige Bausteine für Nukleinsäuren. Ihre chemische Synthese ist aufgrund der geringen Ausbeute der 5′‐Triphosphorylierungsreaktion nur wenig effizient. Wir stellen hier eine universelle, durch Polyphosphat angetriebene Zwei‐Enzym‐Kaskade vor, die eine direkte Phosphorylierung von Nukleosiden zu NTPs ermöglicht ...
Jonathan P. Suess +1 more
wiley +1 more source
Small molecule control of virulence gene expression in Francisella tularensis. [PDF]
PLoS Pathogens, 2009 In Francisella tularensis, the SspA protein family members MglA and SspA form a complex that associates with RNA polymerase (RNAP) to positively control the expression of virulence genes critical for the intramacrophage growth and survival of the ...
James C Charity +4 more
doaj +1 more source
A Universal Nucleoside‐to‐Nucleoside‐5′‐Triphosphate Enzyme Cascade Driven by Polyphosphate
Angewandte Chemie International Edition, EarlyView.Nucleoside‐5′‐triphosphates (NTPs) are essential components for the generation of nucleic acids, yet their chemical synthesis is hindered by the low yield of nucleoside phosphorylation. Here, we present a universal, two‐enzyme nucleoside‐to‐NTP cascade that is driven by polyphosphate.
Jonathan P. Suess +1 more
wiley +1 more source