Results 171 to 180 of about 6,159 (212)
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Synthesis of guanosine tetraphosphate (Magic Spot I) in Saccharomyces cerevisiae
Biochemical and Biophysical Research Communications, 1977Abstract Guanosine tetraphosphate (Magic Spot I) has been found in formic acid extracts of Saccharomyces cerevisiae subjected to heat shock. The yeast compound comigrates with authentic ppGpp in several chromatographic systems, and further tests confirm its identity with the guanosine-5′-diphosphate-3′-diphosphate found in bacteria ...
C C, Pao, J, Paietta, J A, Gallant
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Synergistic inhibition of ATP phosphoribosyltransferase by guanosine tetraphosphate and histidine
Biochemical and Biophysical Research Communications, 1977Abstract In the presence of partially inhibiting concentrations of the feedback inhibitor histidine guanosine-5′-diphosphate-3′-diphosphate becomes a potent inhibitor of the residual activity of ATP phosphoribosyltransferase from Salmonella typhimurium . Inhibition by guanosine tetraphosphate is higher order and slowly reversible.
D P, Morton, S M, Parsons
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Relationship between guanosine tetraphosphate and accuracy of translation in Salmonella typhimurium
Biochemistry, 1989In bacteria a high level of mistranslation is observed in amino acid starved rel-, but not rel+, strains, and mistranslation can be studied qualitatively by means of "stuttering" experiments in two-dimensional protein gels. It has been suggested that the low level of mistranslation that occurs in rel+ strains is assured by guanosine 5'-diphosphate 3 ...
Negre, D. +3 more
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Accumulation of Guanosine Tetraphosphate in T7 Bacteriophage-Infected Escherichia coli
Journal of Bacteriology, 1973Accumulation of guanosine tetraphosphate (ppGpp) in Escherichia coli strain AS19 valS , carrying a temperature-sensitive valyl-transfer ribonucleic acid synthetase and infected with bacteriophage T7, was studied. Valine starvation was achieved by culturing this strain at 42 C.
J D, Friesen, N, Fiil
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Analytical Biochemistry, 1974
Abstract A means of preparative enzymatic synthesis of guanosine tetraphosphate (ppGpp), guanosine pentaphosphate (pppGpp), and related derivatives is deseribed. The Escherichia coli ribosomes can be recovered, stored, and used repeatedly as a source of synthetic activity.
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Abstract A means of preparative enzymatic synthesis of guanosine tetraphosphate (ppGpp), guanosine pentaphosphate (pppGpp), and related derivatives is deseribed. The Escherichia coli ribosomes can be recovered, stored, and used repeatedly as a source of synthetic activity.
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Accumulation of guanosine tetraphosphate induced by polymixin and gramicidin in Escherichia coli
Biochimica et Biophysica Acta (BBA) - General Subjects, 1983The effects of two polypeptide antibiotics, polymixin B and gramicidin S, on the intracellular pool size and turnover of guanosine tetraphosphate (ppGpp) were analyzed in stringent (relA+) and relaxed (relA) strains of Escherichia coli. When either one of these two drugs was added to stringent bacteria cultures at a final concentration that blocked ...
Cortay, Jc, Cozzone, Aj
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Inapparent correlation between guanosine tetraphosphate levels and RNA contents in Escherichia coli
Biochemical and Biophysical Research Communications, 1974Summary We have reexamined the intracellular levels of guanosine 5′-diphosphate 3′-diphosphate in a prototrophic stringent strain of Escherichia coli during balanced growth at eight different growth rates. No regular inverse relationship between the basal levels of this nucleotide and the RNA content per unit DNA was observed. Thus, it is concluded
S R, Khan, H, Yamazaki
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Guanosine tetraphosphate: coordinator of metabolic response to nitrogen starvation in enterobacteria
Trends in Biochemical Sciences, 1979Abstract Deprivation of amino acids brings about major adjustments in bacterial metabolism that are designed to counteract the emergency. These are mediated by pleiotropic regulatory effects of guanosine tetraphosphate (ppGpp), and are felt at the levels of ribosome and membrane biosynthesis, intermediary metabolism and protein turnover. Regulation by
William A. Bridger, William Paranchych
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Archives of Microbiology, 1981
The effect of nitrate deprivation on cell growth and nucleotide level was studied in Anacystis nidulans. A 10-fold reduction in nitrate level resulted in a drastic slowdown of growth. Upon addition of nitrate to the starving cultures, after a lag period, the cells resumed growth.
G M, Friga, G, Borbély, G L, Farkas
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The effect of nitrate deprivation on cell growth and nucleotide level was studied in Anacystis nidulans. A 10-fold reduction in nitrate level resulted in a drastic slowdown of growth. Upon addition of nitrate to the starving cultures, after a lag period, the cells resumed growth.
G M, Friga, G, Borbély, G L, Farkas
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
Abstract Accumulation of guanosine 5′-diphosphate-2′(or 3′)-diphosphate was not detected in Neurospora crassa during a shift-down transition of growth, which restricts RNA synthesis. This is non-supportive evidence for its role as a mediator in the inhibition of stable RNA synthesis in eukaryotic cells.
F. A. Alberghina +3 more
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Abstract Accumulation of guanosine 5′-diphosphate-2′(or 3′)-diphosphate was not detected in Neurospora crassa during a shift-down transition of growth, which restricts RNA synthesis. This is non-supportive evidence for its role as a mediator in the inhibition of stable RNA synthesis in eukaryotic cells.
F. A. Alberghina +3 more
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