Results 91 to 100 of about 40,840 (280)
Structural Studies of Soluble Guanylate Cyclase [PDF]
Biophysical Journal, 2015 Soluble guanylate cyclase (sGC) is a ∼150 kDa heterodimeric enzyme that plays a crucial role in the cardiovascular system by catalyzing the conversion of GTP into cGMP, a secondary messenger whose downstream effects include vasodilation and inhibiting platelet aggregation.
Kenneth Childers +2 more
openaire +2 more sources
Exploration, EarlyView.Schematic illustration of structural and functional biomimicry. The upper part shows BP with various structures such as monolayered, surface‐microstructural, bilayered and multilayered. The bottom part exhibits BP with different functions including immune regulation, drugs/cells/factors/ions loading, as well as bioelectrical stimulation and ...
Yuhan Du +7 more
wiley +1 more source
Characterization of the norepinephrine-activation of adenylate cyclase suggests a role in memory affirmation pathways. Overexposure to epinephrine inactivates adenylate-cyclase,a causal pathway for stress-pathologies [PDF]
BioSystems 100 (2010) p. 87-93, 2010 Incubation with noradrenaline (norepinephrine) of isolated membranes of rat's brain corpus striatum and cortex, showed that ionic-magnesium (Mg2+) is required for the neurotransmitter activatory response of Adenylate Cyclase [ATP pyrophosphate-lyase (cyclizing), (EC 4.6.1.1)], AC.An Mg2+-dependent response to the activatory effects of adrenaline, and ...
arxiv
The dynamics of H-bonds of the hydration shells of ions, ATPase and NE-activated adenylyl cyclase on the coupling of energy and signal transduction [PDF]
arXiv, 2012 Glycerol titration distinguished from free water the local hydration shell involved in ATPase transition from active to inactive, with cooperativity for water n=16. Rat brain cortex: NE-stimulated and its basal AC in the absence of free Mg2+, allows a refractive state of AC with negative cooperativity for MgATP and ATP4-.
arxiv
Aging Cell, EarlyView.Aged rats and human are more susceptible to MASLD‐related liver injury, steatosis, and fibrosis, accompanied by worsening of endothelial dysfunction. The SIRT1/p‐eNOS/NO pathway is involved in aggravated MASLD caused by aging‐related LSECs dysfunction.
Qingqing Dai +5 more
wiley +1 more source
The integrated model of cAMP-dependent DNA expression reveals an inverse relationship between cancer and neurodegeneration [PDF]
arXiv, 2016 The model for cAMP-dependent synaptic plasticity relates the characterization of a noradrenaline-stimulated adenylyl cyclase with DNA unzipping. Specific proteins condition cAMP insertion in specific sites of the DNA structure to direct cellular and synaptic differentiation in brain tissues, also providing coding. Metabolic-dependent ATP binding of Mg2+
arxiv
Pulmonary Circulation, 2017 Riociguat is a soluble guanylate cyclase stimulator used for pulmonary hypertension (PH) treatment. We evaluated right ventricular (RV) contractile function in 27 PH patients receiving riociguat.
Mitsushige Murata +5 more
doaj +1 more source
Nitric oxide and synaptic function [PDF]
, 1994 The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Loss of function of the sperm‐specific Ca2+ channel CatSper is a common channelopathy that causes male infertility. CatSper controls the intracellular Ca2+ concentration and, thereby, the motility of human sperm. Activation of CatSper by oviductal ligands evokes a transient Ca2+ increase, which entails changes in the ...
Leonie Herrmann +11 more
wiley +1 more source
Frontiers in Oncology, 2019 Prostate cancer is the leading cause of cancer death among men globally, with castration development resistant contributing significantly to treatment failure and death.
Solomon Oladapo Rotimi +5 more
doaj +1 more source