Results 171 to 180 of about 40,447 (213)

Soluble guanylate cyclase stimulators for heart failure: a network meta-analysis and subgroup analyses of reduced and preserved ejection fraction. [PDF]

Egypt Heart J
Abuelazm MT, Attia A, Abdelnabi M, Jafar U, Almaadawy O, Elzeftawy MA, Mahmoud A, Albakri K, Abdelazeem B.   +8 more
europepmc   +1 more source

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial. [PDF]

Front Pharmacol
Gui YZ, Wang W, Wu QQ, Ding QC, Qian HJ, Lu QB, Zhang YJ, Zhuang YL, Deng L, Zuo YL, Luo L, Jia JY.   +11 more
europepmc   +1 more source

Phase 1 Study of MK-5475, an Inhaled Soluble Guanylate Cyclase Stimulator, in Participants with Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease. [PDF]

Int J Chron Obstruct Pulmon Dis
Bajwa EK, Cislak D, Kumar A, Li D, Messina EJ, Reynders T, Denef JF, Corcea V, Buch KP, Lai E, Stoch SA.   +10 more
europepmc   +1 more source

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Guanylate Cyclase Activating Proteins, Guanylate Cyclase and Disease

2002
A range of cone and cone-rod dystrophies (CORD) have been observed in man, caused by mutations in retinal guanylate cyclase 1 (RetGC1) and guanylate cyclase activating protein 1 (GCAP 1). The CORD causing mutations in RetGC1 are located at a mutation "hot spot" within the dimerisation domain, where R838 is the key residue.
Richard J, Newbold, Evelyne C, Deery, Annette M, Payne, Susan E, Wilkie, David M, Hunt, Martin J, Warren   +5 more
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Soluble guanylate cyclase

Current Opinion in Structural Biology, 2006
Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO binds to the sGC heme, its GTP cyclase activity markedly increases, thus generating cyclic GMP, which serves to regulate several cell signaling functions. A good deal is known about the kinetics and equilibrium of binding of NO to sGC, leading to a proposed multistep ...
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Guanyl cyclase of Bacilluslicheniformis

Biochemical and Biophysical Research Communications, 1972
Abstract Guanyl cyclase activity was detected in extracts of Bacillus licheniformis strain A-5. The enzyme is associated with the 105,000 × g particulate fraction of the extract, requires Mn++ for full activity, has a pH optimum of 8.5, and has an apparent Km for GTP of 5mM.
V L, Clark, R W, Bernlohr
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Both soluble guanylate cyclase and particulate guanylate cyclase regulate myometrial contractility

American Journal of Obstetrics and Gynecology, 1998
Our purpose was to compare the effects of agents stimulating particulate and soluble guanylate cyclase with spontaneous rat uterine contractions at midgestation and term.Uterine rings from midgestation (day 13) and term nonlaboring (day 22) rats were positioned in organ chambers for isometric force recording.
A S, Syal, Y P, Vedernikov, K, Chwalisz, G R, Saade, R E, Garfield   +4 more
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Guanyl‐Cyclase

European Journal of Biochemistry, 1970
An enzyme system catalyzing the formation of guanosine cyclic 3′:5′‐monophosphate (Guo‐3′:5′‐P) from GTP has been found in various tissues of the rat including kidney, spleen, liver, brain, heart, skeletal muscle and adipose tissue. The highest guanyl cyclase activity was measured in the lung.
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Nicotine decreases guanylate cyclase activity

Bulletin of Environmental Contamination and Toxicology, 1978
The cyclic nucleotide, guanosine 3',5'-monophosphate (cyclic GMP) appears to serve a critical role in normal cell growth, DNA synthesis, and carcinogenesis (GOLDBERG et al. 1977). Tobacco smoke and hydrazine, a carcinogen which occurs in tobacco and tobacco smoke, have been shown to stimulate guanylate cyclase [E.C.
D L, Vesely, G S, Levey
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