Results 131 to 140 of about 323,472 (305)

Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity

, 2015
EC is supported by the Alexander von Humboldt Foundation, the German Federal Ministry for Education and Research, the Helmholtz Association, the Göran Gustafsson Foundation, the Swedish Research Council, the Kempe Foundation and Umeå University.
White, Malcolm F., Charpentier, Emmanuelle, White, Malcolm F, van der Oost, John, Richter, Hagen   +4 more
core   +1 more source

Structural Features of the Guide:Target RNA Duplex Required for Archaeal C/D sRNA Guided Nucleotide 2'-O-methylation.

, 2006
Archaeal box C⁄D sRNAs guide the 2'-O-methylation of target nucleotides in both ribosomal and tRNAs. These small non-coding RNAs are characterized by conserved terminal box C⁄D and internal C'⁄D' RNA motifs. Each RNA motif binds three
Appel, Cathryn Denise
core  

Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters

, 2010
Antigene RNAs (agRNAs) are small RNA duplexes that target non-coding transcripts rather than mRNA and specifically suppress or activate gene expression in a sequence-dependent manner.
Charisse, Klaus, Yu, Dongbo, Montaillier, Christophe, Potier, Pierre, Corey, David R., Manoharan, Muthiah, Watts, Jonathan K.   +6 more
core   +1 more source

Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system

, 2014
This research was funded in part by Biotechnology and Biological Sciences Research Council [BB/K000314/1]. The APC was paid through RCUK OA block grant funds.CRISPR-Cas is an adaptive prokaryotic immune system, providing protection against viruses and ...
Malcolm F. White, White, Malcolm F, Shirley Graham, Sokolowski, Richard David, Graham, Shirley, Richard D. Sokolowski   +5 more
core   +1 more source

RNA-Guided RNA Modifications: Biogenesis, Functions, and Applications

ConspectusPost-transcriptional modifications are ubiquitous in both protein-coding and noncoding RNAs (ncRNAs), playing crucial functional roles in diverse biological processes across all kingdoms of life.
Bin Li (39349), Jianhua Yang (653859), Lianghu Qu (12005033)   +2 more
core   +1 more source

CRISPR/Cas13-Based Anti-RNA Viral Approaches

RNA viruses pose significant threats to global health, causing diseases such as COVID-19, HIV/AIDS, influenza, and dengue. These viruses are characterized by high mutation rates, rapid evolution, and the ability to evade traditional antiviral therapies ...
Toischer, Karl, Hasenfuß, Gerd, Xiaoying Tan, Juncong Li, Li, Juncong, Wu, Jingjing, Xingbo Xu, Tan, Xiaoying, Gerd Hasenfuß, Xu, Xingbo, Jingjing Wu, Baolong Cui, Karl Toischer, Cui, Baolong   +13 more
core   +1 more source

Small RNA Sorting in Drosophila Produces Chemically Distinct Functional RNA-Protein Complexes: A Dissertation

, 2008
Small interfering RNAs (siRNAs), microRNAs (miRNAs), and piRNAs (piRNA) are conserved classes of small single-stranded ~21-30 nucleotide (nt) RNA guides that repress eukaryotic gene expression using distinct RNA Induced Silencing Complexes (RISCs).
Horwich, Michael D.
core   +1 more source

Improved bacterial RNA-seq by Cas9-based depletion of ribosomal RNA reads.

, 2020
A major challenge for RNA-seq analysis of gene expression is to achieve sufficient coverage of informative nonribosomal transcripts. In eukaryotic samples, this is typically achieved by selective oligo(dT)-priming of messenger RNAs to exclude ribosomal ...
Homberger, Christina, Vogel, Jörg, Heckel, Tobias, Westermann, Alexander J, Dietrich, Sascha, Prezza, Gianluca   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source