Results 101 to 110 of about 553,709 (304)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Penerapan Model Inquri Terbimbing Disertai Peta Konsep Dalam Pembelajaran Fisika Di Man 1 Jember [PDF]

open access: yes, 2015
Process guided inquiry with a concept map; 2) to study the effect of guided inquiry models with concept maps to physics student learning achievement. This study is experimental research with posttest-only control design. The population is all of X degree
Bektiarso, S. (Singgih)   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

The Effect of the Guided Inquiry Learning Model on Critical Thinking Skills in Science Education: A Systematic Literature Review

open access: yesThinking Skills and Creativity Journal
Students’ critical thinking skills in science learning remain underdeveloped due to teacher-centered instructional practices that limit active engagement in inquiry and reasoning. This study aims to analyze empirical evidence on the effect of the guided
Luh Ririn Indahyani   +4 more
doaj   +1 more source

Guided inquiry of genomics in NMPDR

open access: yesThe FASEB Journal, 2007
Bioinformatics has become an indispensable tool in the arsenal of biochemists and molecular biologists. Most of today's experimental research relies on in silico analytical tools for making sense of the gathered data, making predictions, and formulating working hypotheses.
Leslie Klis McNeil, Claudia Reich
openaire   +1 more source

IMPLEMENTASI PENDEKATAN SETS DENGAN METODE INKUIRI TERBIMBING DAN PROYEK DITINJAU DARI SIKAP ILMIAH DAN KREATIVITAS SISWA [PDF]

open access: yes, 2013
The aims of the research are to know the effect of implementation of SETS approach, using guided inquiry and project methods, students scientific attitude, creativity and its interaction toward student achievement.
Mariyana, Tatik
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

PENGARUH MODEL PEMBELAJARAN OPEN INQUIRY DAN GUIDED INQUIRY TERHADAP SIKAP ILMIAH SISWA SMP PADA TEMA SUHU DAN PERUBAHAN

open access: yesEDUSAINS, 2016
Tujuan penelitian ini adalah untuk menganalisis perbedaan sikap ilmiah antara siswa yang menggunakan model pembelajaran Open Inquiry dengan siswa yang menggunakan model pembelajaran Guided Inquiry pada tema suhu dan perubahan.
Dwi Indah Suryani, Dwi Indah Suryani
doaj   +1 more source

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