Results 101 to 110 of about 7,672,395 (400)
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
Lay epidemiology and the interpretation of low-risk drinking guidelines by adults in the United Kingdom [PDF]
, 2015 Aims To explore how the concept of lay epidemiology can enhance understandings of how drinkers make sense of current UK drinking guidelines. Methods Qualitative study using 12 focus groups in four sites in northern England and four sites in ...
Bauld, Linda +6 more
core +4 more sources
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Documentary of the 2nd Global Evidence Summit: collaborating in a new era of evidence-based science
Guangxi Yike Daxue xuebaoFrom 10-13 September 2024, the 2nd Global Evidence Summit was held in Prague, the capital of the Czech Republic. The conference featured in-depth discussions on six themes: sustainable development agenda, research integrity making evidence accessible ...
LIU Hui +7 more
doaj +1 more source
Incorporating patient preferences in the management of multiple long-term conditions: is this a role for clinical practice guidelines? [PDF]
, 2015 Background: Clinical practice guidelines provide an evidence-based approach to managing single chronic conditions, but their applicability to multiple conditions has been actively debated.
Boyle, Frances M. +3 more
core +3 more sources
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Cancer Informatics, 2020 Prognostic markers for cancer can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities. Gallbladder cancer (GBC) is a rare tumor that causes 165 087 deaths in the world annually. It
Vívian D’Afonseca +7 more
doaj +1 more source
Guidelines for structuring learning and teaching opportunities relevant to educators’ open educational resource (OER) engagement [PDF]
, 2015 Six guidelines for structuring learning and teaching opportunities relevant to educators’ open educational resource (OER) engagement are proposed in this document.
Hood, Nina, Littlejohn, Allison
core +1 more source
Design guidelines for spatial modulation
, 2014 A new class of low-complexity, yet energyefficient Multiple-Input Multiple-Output (MIMO) transmission techniques, namely the family of Spatial Modulation (SM) aided MIMOs (SM-MIMO) has emerged.
Di Renzo, Marco +4 more
core +3 more sources