Results 191 to 200 of about 355,515 (377)

Exploring the Activation of the Keap1‐Nrf2‐ARE Pathway by PAHs in Children's Toys

open access: yesContact Dermatitis, EarlyView.
Our study evaluated the skin sensitisation risk of polycyclic aromatic hydrocarbons (PAHs) in toys, revealing that B[k]F, B[b]F and chrysene are highly potent sensitizers. Synergistic effects in PAH mixtures underscore the need to consider combined exposures when assessing environmental risks to children.
Jonas Lauenstein   +6 more
wiley   +1 more source

Effects of Tegaserod on Ileal Peristalsis of Guinea Pig In Vitro

open access: yesJournal of Pharmacological Sciences, 2004
The mechanisms of prokinetic action of tegaserod in the gastrointestinal tract has not been studied in detail. The aim of this study was to investigate the effect of tegaserod on peristaltic reflexes and propagating peristaltic waves in guinea pig ileum.
Sang Won Ji   +4 more
doaj  

Requirements for Alternative In Vitro and In Silico Skin Models of Irritant and Allergic Contact Dermatitis

open access: yesContact Dermatitis, EarlyView.
ABSTRACT Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should ...
Meital Portugal‐Cohen   +9 more
wiley   +1 more source

Testis‐Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis

open access: yesCell Proliferation, EarlyView.
PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang   +9 more
wiley   +1 more source

GLYCOGENESIS IN THE LIVER OF THE FETAL GUINEA PIG

open access: hybrid, 1954
Andrew M. Nemeth   +2 more
openalex   +1 more source

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