Results 41 to 50 of about 360,883 (358)

Guinea pig breeding and its relation to sustainable food security and sovereignty in South America: nutrition, health, and production challenges

CyTA - Journal of Food
This review explores the economic impact and importance of guinea pig production for sustainable food security and sovereignty in South America. The ease of management, short reproductive cycles of 16 days, and profitability make guinea pig farming ...
Yamid Pinchao-Pinchao, Liliana Serna-Cock, Oswaldo Osorio-Mora, Diego F. Tirado   +3 more
doaj   +1 more source

Polyanhydride‐Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single‐Injection Self‐Boosting Vaccines

Advanced Materials, EarlyView.
This study presents a polyanhydride‐based delivery platform for single‐injection, self‐boosting vaccines. The system enables programmable, pulsatile release of diphtheria toxoid with high antigen recovery and is guided by machine learning for tunability. In vivo results show immune responses comparable to multi‐dose regimens, highlighting its potential
Linzixuan Zhang, Ruiqing Xiao, Wenhao Gao, Johnny Garcia, Xinyan Pan, John L. Daristotle, Timothy Forster, Jooli Han, Mehr Chaddah, Dhruv Varshney, Nandita Menon, Kevin J. McHugh, Benjamin J. Pedretti, Jing Ying Yeo, Xin Yang, Sydney MacDonald, Robert Langer, Ana Jaklenec   +17 more
wiley   +1 more source

Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models

Scientific Reports, 2022
Asthma is a common respiratory disease associated with airway hyperresponsiveness (AHR), airway inflammation and mast cell (MC) accumulation in the lung. Monensin, an ionophoric antibiotic, has been shown to induce apoptosis of human MCs. The aim of this
Jielu Liu, Mu Nie, Caijuan Dong, Jesper Säfholm, Gunnar Pejler, Gunnar Nilsson, Mikael Adner   +6 more
doaj   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290 [PDF]

, 2015
Relaxin peptide (RLN), which signals through the relaxin family peptide 1 (RXFP1) GPCR receptor, has shown therapeutic effects in an acute heart failure clinical trial.
Alexander I Agoulnik, Amaya eBueno, Brian eHo, Courtney eMyhr, Elena eBarnaeva, Irina U Agoulnik, Jingbo eXiao, Juan eMarugan, Marc eFerrer, Noel eSouthall, Ross A.D. Bathgate, Xin eHu, Zaohua eHuang   +12 more
core   +3 more sources

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Karyotype of Hairless Guinea pig [PDF]

Journal of Sciences, Islamic Republic of Iran, 2013
Chromosomal patterns of experimental animals are useful tools for cytogenetics research and animal breeding. Chromosome investigations of the hairless guinea pig are rare, therefore, karyotype of hairless guinea pigs (twelve male and female) was studied ...
fatemeh Todehdehghani, Mohammah hassan motedayen, Shohreh Teimorzadeh   +2 more
doaj  

Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action [PDF]

, 2014
A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and ...
Alcaraz L., Alikhani V., Anderson G. P., Austin R. P., Bao Y., Baur F., Bouyssou T., Cazzola M., Connolly S., Cooper A. E., Davies S. L., Deyrup M. D., Fuso L., Giles M. E., Green S. A, Kuna P., Matera M. G., Mortimer K. J., Patton J. S., Procopiou P. A., Procopiou P. A., Roig J., Stocks M. J., Tayab Z. R., Walker J. K. L., Walland A., White M. V.   +26 more
core   +2 more sources

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Le cobaye Cavia porcellus L., comme animal de boucherie au Cameroun [PDF]

Tropicultura, 1994
Guinea Pig Cavia porcellus L. As A Meat Producing Animal In Cameroon. Guinea pig Cavia porcellus farming for meat production remains a marginalised activity in Cameroon in spite of the advantages this specie offers.
Ngou Ngoupayou, JD., Fotso, JM., Kouonmenioc, J.   +2 more
doaj