Results 81 to 90 of about 911,964 (393)
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus. [PDF]
PLoS Pathogens, 2016 In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital ...
Stewart Coleman +3 more
doaj +1 more source
Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity
Advanced Science, EarlyView.Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini +24 more
wiley +1 more source
Advanced Science, EarlyView.Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl +27 more
wiley +1 more source
Ultrastructural and Chemical Composition of Dentin and Enamel in Lab Animals [PDF]
Journal of Dentistry, 2019 Statement of the Problem: Human tooth is clinically the most appropriate material that can be used for in-vitro dental research. However, there are limitations and drawbacks for using human teeth.
Ali Dehghani Nazhvani +3 more
doaj
Identification of the prostanoid receptor mediating PGE2-induced cough
, 2009 Prostaglandin E2 (PGE2) may provide a novel therapy for the treatment of inflammatory airway diseases as it has been shown to confer both bronchodilator and anti-inflammatory activity in asthmatic subjects.
Maher, Ann, Maher, Ann
core +1 more source
Advanced Science, EarlyView.Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng +15 more
wiley +1 more source
Saintika Medika, 2017 Ma’roef, Arifatul. The Influence of Tamarind (Tamarindus indica) Fruit Extract On Reducing Isolated Uterine Smooth Muscle Contraction of Female Guinea Pig (Cavia porcellus) Background : Tamarind (Tamarindus indica) is medicinal plant that is easy to get ...
Mochamad Ma’roef, Arifatul Jannah2
doaj +1 more source
A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K+ channels in carbon monoxide–induced proarrhythmic early afterdepolarizations [PDF]
, 2017 Exposure to carbon monoxide (CO) causes early afterdepolarization arrhythmias. Previous studies in rats indicated arrhythmias arose due to augmentation of the late Na+ current.
Chris Peers +8 more
core +2 more sources
Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance
Advanced Science, EarlyView.DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin +15 more
wiley +1 more source