Results 61 to 70 of about 230,938 (301)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress

Journal of Education, Health and Sport, 2017
We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde ) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs  under the conditions of immobilization ...
Mykhailo Stepanovych Reheda, Marta Yevhenivna Kovalska, Mariana Ljubomurivna Baida   +2 more
doaj   +3 more sources

Transmission and pathogenicity of novel reassortants derived from Eurasian avian-like and 2009 pandemic H1N1 influenza viruses in mice and guinea pigs [PDF]

, 2016
Given the present extensive co-circulation in pigs of Eurasian avian-like (EA) swine H1N1 and 2009 pandemic (pdm/09) H1N1 viruses, reassortment between them is highly plausible but largely uncharacterized.
A Krumbholz, AV Cauldwell, B Manz, C Chiapponi, C Scholtissek, E Starick, GF Rimmelzwaan, GJ Smith, H Liang, H Yang, H Zhou, H Zhu, IH Brown, J Liu, J Pu, JA Vazquez-Perez, JC De Jong, K Shinya, M Pensaert, M Wedde, MA Jhung, N Marshall, NA Gerloff, NM Bouvier, Q Liu, Q Liu, R Zell, RA Perera, RK Nelli, S Chutinimitkul, SJ Watson, T Watanabe, W Kong, W Ma, W Ma, WL Kong, WL Kong, X Qi, X Xiong, X Zhao, XC Yin, Y Abed, Y Kawaoka, YK Choi   +43 more
core   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Neoplastic and Non-Neoplastic Proliferative Mammary Gland Lesions in Female and Male Guinea Pigs: Histological and Immunohistochemical Characterization

Animals
Mammary tumors occur in female and male guinea pigs. However, published data on their histology and sex predispositions are limited. Histologically, we examined proliferative mammary lesions of 69 female and 48 male pet guinea pigs.
Sandra Schöniger, Claudia Schandelmaier, Heike Aupperle-Lellbach, Christina Koppel, Qian Zhang, Hans-Ulrich Schildhaus   +5 more
doaj   +1 more source

Physical and Physiological Indicators of Welfare in Guinea Pigs (Cavia porcellus) Serving as Ambassador Animals

Animals, 2020
Special encounters that allow contact between animals and guests are common in zoos and aquariums. Visitors to the Saint Louis Zoo may touch guinea pigs serving as ambassador animals.
David M. Powell, Corinne P. Kozlowski, John Clark, Alice Seyfried, Eli Baskir, Ashley D. Franklin   +5 more
doaj   +1 more source

A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. [PDF]

, 1993
Using an in vivo test system, the role of the β1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic inflammatory reactions was investigated.
Lobb, RR, Nourshargh, S, Weg, VB, Williams, TJ   +3 more
core   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

The prevalence of Serpulina pilosicoli in humans and domestic animals in the Eastern Highlands of Papua New Guinea [PDF]

, 1997
In a survey of five villages in the Eastern Highlands of Papua New Guinea, Serpulina pilosicoli was isolated from rectal swabs from 113 of 496 individuals (22·8%). Colonization rates ranged from 22·6–30·1% in four of the villages but was only 8·6% in the
Trott, D.J., Combs, B.G., Mikosza, A.S.J., Oxberry, S.L., Robertson, I.D., Passey, M., Taime, J., Sehuko, R., Alpers, M.P., Hampson, D.J.   +9 more
core   +2 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source