Results 81 to 90 of about 113,058 (259)

Morphological and vascular evidence of glaucomatous damage in myopic guinea pigs with scleral crosslinking

open access: yesScientific Reports
Guinea pigs are often used as models for myopia studies. However, the imaging structure and vasculature of the optic nerve head (ONH) in guinea pigs are tentative.
Lei Guo   +6 more
doaj   +1 more source

Adapting to Change: The Dynamic Crop Production Systems of Smallholder Farmers in the PNG Highlands

open access: yesAsia Pacific Viewpoint, EarlyView.
ABSTRACT Smallholder sweet potato farmers in Papua New Guinea's Eastern Highlands Province (EHP) face challenges as they navigate social, economic, demographic, and environmental change. While they routinely adapt to weather variability and shifting markets, population growth is placing additional strain on an already finely balanced farming system ...
Geoff Kuehne   +9 more
wiley   +1 more source

Comparative analysis of rodent lens morphometrics and biomechanical properties

open access: yesFrontiers in Ophthalmology
IntroductionProper ocular lens function requires biomechanical flexibility, which is reduced during aging. As increasing lens size has been shown to correlate with lens biomechanical stiffness in aging, we tested the hypothesis that whole lens size ...
Sepideh Cheheltani   +9 more
doaj   +1 more source

Indigenous‐Led Adaptation to Complex Climate Risks in New Ireland, Papua New Guinea

open access: yesAsia Pacific Viewpoint, EarlyView.
ABSTRACT Pacific Island peoples have long histories of adapting to environmental changes, but recent climate change is now driving complex risks that unfold within rapidly shifting societal and environmental contexts. This study investigates how remote Indigenous communities in New Ireland, Papua New Guinea, experience and want to respond to complex ...
Eric Lede   +3 more
wiley   +1 more source

Generative artificial intelligence in higher education: Emotional tensions and ethical declaration

open access: yesBritish Journal of Educational Technology, EarlyView.
Abstract The increasing use of Generative Artificial Intelligence (GenAI) tools such as ChatGPT in higher education has raised questions about authorship, ethical responsibility, and academic transparency. While institutional guidelines exist, many remain vague and ineffective, leaving students to interpret disclosure obligations on their own.
Yao Qu, Hui En Loo, Jue Wang
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

open access: yesBritish Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

open access: yesBritish Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan   +3 more
wiley   +1 more source

Comparative study on the effects of high fat diet and capsicum diet on the digestive organs of guinea pigs

open access: yesScientific Reports
This study examined the different effects of high-fat and capsicum diets on the digestive organs of guinea pigs. Hartley guinea pigs (n = 24) were divided into the high-fat diet (HFD), capsicum diet (CD), and control (C) groups. Guinea pigs in the C, HFD,
Wen-Xiang Guan   +4 more
doaj   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

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