Results 81 to 90 of about 311,598 (350)

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Optimizing information in the herd : guinea pigs, profits, and welfare [PDF]

, 2002
Herding arises when an agent's private information is swamped by public information in what M. O. Jackson and E. Kalai (1997, Games Econ. Behavior21, 102–134) call a recurring game.
Sgroi, Daniel
core   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, EarlyView.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

Humane Euthanasia of Guinea Pigs (Cavia porcellus) with a Penetrating Spring-Loaded Captive Bolt

Animals, 2020
Guinea pigs (Cavia porcellus) have been used in research since the 19th century to collect data due to their physiological similarities to humans. Today, animals perform a vital role in experiments and concerns for laboratory animal welfare are enshrined
Shari Cohen, Melody Kwok, Joel Huang
doaj   +1 more source

Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis

Advanced Science, EarlyView.
This study shows that mammary branching morphogenesis is regulated by extracellular matrix (ECM) stress relaxation. Slow stress‐relaxing matrices promote branching through focal adhesion signaling, collagen fiber alignment, and cell contractions, whereas fast stress‐relaxing matrices impair branching and collagen alignment.
Daniella I. Walter, Juliette W. Moore, Abhishek Sharma, Ryan S. Stowers   +3 more
wiley   +1 more source

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

First detection and genotyping of Enterocytozoon bieneusi in pet fancy rats (Rattus norvegicus) and guinea pigs (Cavia porcellus) in China

Parasite, 2020
Enterocytozoon bieneusi, an obligate intracellular microsporidian parasite, can infect humans and a wide variety of animals worldwide. However, information on the prevalence and molecular characterization of E.
Wang Jingsong, Lv Chaochao, Zhao Diandian, Zhu Runan, Li Chen, Qian Weifeng   +5 more
doaj   +1 more source

Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in guinea pigs [PDF]

, 2020
Na Zhao, Xiangrong Song, Hisao Naito, Hongling Li, Yongshun Huang, Lili Liu, Fengrong Lu, Tingfeng Cai, Yuki Ito, Michihiro Kamijima, Hanlin Huang, Tamie Nakajima, Hailan Wang   +12 more
openalex   +1 more source

Adropin modulates pancreatic cell proliferation and glutathione levels in an animal model of type 1 diabetes mellitus

Animal Models and Experimental Medicine, EarlyView.
Adropin is related to the energy homeostasis‐associated gene. It significantly increased glutathione reductase enzyme levels in the pancreas of experimental diabetic rats. Adropin may reduce the severity of diabetes and its complications. Cell proliferation in the exocrine is reduced after the administration of adropin.
Ifrah I. Ali, Crystal D'Souza, Abderrahim Nemmar, Shreesh Ojha, Ernest A. Adeghate   +4 more
wiley   +1 more source

Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs

Virology Journal, 2009
Mice and guinea pigs were experimentally exposed to aerosols containing regionally-distinct strains (NJ1959 or ArgM) of eastern equine encephalitis virus (EEEV) at two exclusive particle size distributions.
Norris Sarah, Hartings Justin, Wilhelmsen Catherine L, Reed Douglas S, Roy Chad J, Steele Keith E   +5 more
doaj   +1 more source