Results 171 to 180 of about 55,170 (288)

β-Glucuronidase at the Microbiota-Host Interface: Dual Regulatory Roles and Precision Modulation by Natural Products. [PDF]

Molecules
Shen J, Xu S, Zhao Q, Zhang J, Zhang H.
europepmc   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

"Pseudo-Spleen Sign" on Gastric Ultrasound in the Supine Position: A Case Report of a Patient With Delayed Gastric Emptying. [PDF]

Cureus
Sekiya S, Jujo S, Ro S, Okamoto H.
europepmc   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

CD64 binding potential does not translate into enhanced therapeutic efficacy for anti-IL-23 antibodies under physiologically relevant conditions. [PDF]

Mol Med
Cohen-Solal JF, Pohl CS, Cummings SM, Gygi JP, Safikhani Z, Bartocha B, Buckley CD, Dong Y, Eyerich K, Karsen SD, Lynch GR, Macoritto M, Morisset PA, Nelson OD, Radstake T, Rieder F, Rivas J, Savaryn JP, Smith KM, Stulir M, Szynal C, Tylek C, Veldman GM, Wasserman LG, Westmoreland S, Chaudhary N, Staron MM.   +26 more
europepmc   +1 more source

Efficacy and Safety of Guselkumab in Participants With Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of a Phase 3, Randomized, Placebo‐Controlled Study

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the efficacy and safety of guselkumab, an interleukin‐23p19 subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor (TNF) inhibitor.
Alexis Ogdie, Joseph F. Merola, Philip J. Mease, Christopher T. Ritchlin, Jose U. Scher, Kimberly Parnell Lafferty, Daphne Chan, Soumya D. Chakravarty, Wayne Langholff, Yanli Wang, Jie Shao, Yevgeniy Krol, Alice B. Gottlieb   +12 more
wiley   +1 more source

High-throughput identification of bacterial β-glucuronidase inhibitors using machine learning. [PDF]

Gut Microbes
Zhang B, Yue H, Skalse A, Sangfuang N, Shorthouse D, Gaisford S, Basit AW.   +6 more
europepmc   +1 more source

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double‐Blind, Proof‐of‐Concept Study

Arthritis &Rheumatology, EarlyView.
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher, Iain B. McInnes, Enrique R. Soriano, Joseph F. Merola, Paul Bird, Vinod Chandran, Edaire Cheng, Elena Reynoso, Warner Chen, Maoji Li, Lianne S. Gensler, Philip J. Mease, Christopher T. Ritchlin   +12 more
wiley   +1 more source

Functional analysis of <i>ARR</i>, <i>MYC</i>, and <i>FLS</i> genes in alfalfa under salt stress using <i>Agrobacterium rhizogenes</i>-mediated composite plants. [PDF]

Plant Signal Behav
Lu Y, Kang B, Yang L, Li J, Khan S, Korai SK, Zulfiqar U, Alqahtani MD, Alasmari A, Gururani MA, Wang X.   +10 more
europepmc   +1 more source

Comparing the outcomes of the technology‐enhanced learning of sectional anatomy with and without preceding demonstrations: A study about the worked‐example effect in anatomy education

Anatomical Sciences Education, EarlyView.
Abstract The examination of anatomical cross‐sections can facilitate the understanding of spatial and clinical anatomy. Visualization technologies, with dynamic and interactive displays, can be used to learn sectional anatomy in a mostly self‐directed manner.
Guilherme Reis Borges Coelho Fonseca, George Lim Tipoe, Fraide Augustin Ganotice Jr   +2 more
wiley   +1 more source